BGC0000190 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000190 (Streptomyces sp. SANK 61196)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	28,713	High	A-74528	PKS

BGC0000190 - Region 1 - T2PKS

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Location: 1 - 28,713 nt. (total: 28,713 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,714
Label		BGC0000190

Tailoring functions

Oxidoreductases: dehydrogenase

sanC: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

sanO: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase methyltransferase transferase

san1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

san2: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

sanN: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

sanV: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

sanD: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

sanI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

sanF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

sanG: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

sanS: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000190.5	1.00	PKS	A-74528	Streptomyces sp. SANK 61196
BGC0000224.4	0.81	PKS	fredericamycin A	Streptomyces griseus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.64	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.60	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000190.5	1.00	PKS	A-74528	Streptomyces sp. SANK 61196
BGC0000224.4	0.81	PKS	fredericamycin A	Streptomyces griseus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.64	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001160.5	0.62	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.60	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

san2: mal

PKS_AT (16..304): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 54.9
Methylmalonyl-CoA: 41.4
Methoxymalonyl-CoA: 38.9
Propionyl-CoA: 25.0
inactive: 19.6
Ethylmalonyl-CoA: 19.6
fatty_acid: 18.5
trans-1,2-CPDA: 15.8
2-Methylbutyryl-CoA: 12.1
Acetyl-CoA: 10.4
CHC-CoA: 9.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 28713
Starter unit(s):: hexadienyl-CoA (Score: 1341.0; E-value: 0)
malonamyl-CoA (Score: 573.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 727.7; E-value: 6.8e-222)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: hexadienyl-CoA_11: 512 Da
hexadienyl-CoA_12: 554 Da
malonamyl-CoA_11: 503 Da
malonamyl-CoA_12: 545 Da

san2: AT (Score: 444.4; E-value: 5.9e-136); AT ADG86309.1_A-74528_hexadienyl-CoA (Score: 674.0; E-value: 0.0)
sanC: KR (Score: 231.3; E-value: 3.6e-71)
sanD: CYC C4-C21/C2-C23|C2-C19 (Score: 174.9; E-value: 8.4e-55)
sanE: CYC C5-C18 (Score: 201.4; E-value: 1e-62)
sanF: KS (Score: 744.7; E-value: 5.9e-227)
sanG: CLF 11|12 (Score: 727.7; E-value: 6.8e-222)
sanH: ACP (Score: 101.9; E-value: 3.3e-32)
sanI: CYC C9-C14 (Score: 246.7; E-value: 1.6e-76)
sanN: MET C11O (Score: 529.9; E-value: 5.3e-162)
sanO: KR C19 (Score: 429.6; E-value: 8.6e-132)
sanS: KSIII (Score: 425.3; E-value: 3.9e-130); KSIII ADG86328.1_A-74528_hexadienyl-CoA (Score: 667.0; E-value: 0.0)
sanV: AMID (Score: 773.5; E-value: 2.9e-235); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 573.0; E-value: 0.0)