BGC0000190 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000190 (Streptomyces sp. SANK 61196)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	28,713	A-74528	PKS	100%

BGC0000190 - Region 1 - T2PKS

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Location: 1 - 28,713 nt. (total: 28,713 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,714
Label		BGC0000190

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000190	1.00	Polyketide	A-74528	Streptomyces sp. SANK 61196
BGC0000224	0.55	Polyketide	fredericamycin A	Streptomyces griseus
BGC0000231	0.31	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000885	0.31	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000234	0.31	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000846	0.28	Other	tabtoxin	Pseudomonas syringae
BGC0001723	0.27	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000275	0.27	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000937	0.27	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000243	0.27	Polyketide	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000190	1.00	Polyketide	A-74528	Streptomyces sp. SANK 61196
BGC0000224	0.81	Polyketide	fredericamycin A	Streptomyces griseus
BGC0000231	0.65	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000885	0.65	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000234	0.64	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000846	0.61	Other	tabtoxin	Pseudomonas syringae
BGC0001723	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000275	0.61	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0000937	0.61	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000243	0.60	Polyketide	nonactin, monactin, dinactin, trinactin, tetranactin	Streptomyces griseus subsp. griseus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

san2

PKS_AT (16..304): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 54.9
Methylmalonyl-CoA: 41.4
Methoxymalonyl-CoA: 38.9
Propionyl-CoA: 25.0
inactive: 19.6
Ethylmalonyl-CoA: 19.6
fatty_acid: 18.5
trans-1,2-CPDA: 15.8
2-Methylbutyryl-CoA: 12.1
Acetyl-CoA: 10.4
CHC-CoA: 9.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 28713
Starter unit(s):: hexadienyl-CoA (Score: 1341.0; E-value: 0)
malonamyl-CoA (Score: 573.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 727.7; E-value: 6.8e-222)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: hexadienyl-CoA_11: 512 Da
hexadienyl-CoA_12: 554 Da
malonamyl-CoA_11: 503 Da
malonamyl-CoA_12: 545 Da

san2: AT (Score: 444.4; E-value: 5.9e-136); AT ADG86309.1_A-74528_hexadienyl-CoA (Score: 674.0; E-value: 0.0)
sanC: KR (Score: 231.3; E-value: 3.6e-71)
sanD: CYC C4-C21/C2-C23|C2-C19 (Score: 174.9; E-value: 8.4e-55)
sanE: CYC C5-C18 (Score: 201.4; E-value: 1e-62)
sanF: KS (Score: 744.7; E-value: 5.9e-227)
sanG: CLF 11|12 (Score: 727.7; E-value: 6.8e-222)
sanH: ACP (Score: 101.9; E-value: 3.3e-32)
sanI: CYC C9-C14 (Score: 246.7; E-value: 1.6e-76)
sanN: MET C11O (Score: 529.9; E-value: 5.3e-162)
sanO: KR C19 (Score: 429.6; E-value: 8.6e-132)
sanS: KSIII (Score: 425.3; E-value: 3.9e-130); KSIII ADG86328.1_A-74528_hexadienyl-CoA (Score: 667.0; E-value: 0.0)
sanV: AMID (Score: 773.5; E-value: 2.9e-235); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 573.0; E-value: 0.0)