BGC0000191 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000191 (Streptomyces galilaeus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,PKS-like	1	25,883	aclacinomycin	PKS	100%

BGC0000191 - Region 1 - PKS-like,T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 25,883 nt. (total: 25,883 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,884
Label		BGC0000191

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000191	2.00	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000192	1.51	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000212	0.92	Polyketide	cinerubin B	Streptomyces sp. SPB074
BGC0000272	0.82	Polyketide	spore pigment	Streptomyces collinus
BGC0000217	0.77	Polyketide	daunorubicin	Streptomyces sp.
BGC0000218	0.73	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000231	0.69	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.66	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002733	0.64	Other	sinapigladioside	Burkholderia gladioli
BGC0000278	0.64	Polyketide	urdamycin	Streptomyces fradiae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000191	1.00	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000192	0.91	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000212	0.76	Polyketide	cinerubin B	Streptomyces sp. SPB074
BGC0000272	0.72	Polyketide	spore pigment	Streptomyces collinus
BGC0000217	0.71	Polyketide	daunorubicin	Streptomyces sp.
BGC0000218	0.69	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000231	0.68	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.66	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002733	0.65	Other	sinapigladioside	Burkholderia gladioli
BGC0000278	0.65	Polyketide	urdamycin	Streptomyces fradiae

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

aknF

PKS_AT (13..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 43.2
Methylmalonyl-CoA: 34.3
Methoxymalonyl-CoA: 31.9
Propionyl-CoA: 20.9
2-Methylbutyryl-CoA: 10.8
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 25883
Starter unit(s):: propionyl-CoA (Score: 1392.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 684.9; E-value: 6.9e-209)
Product class(es):: anthracycline
Product molecular weight(s):: propionyl-CoA_8: 558 Da
propionyl-CoA_9: 600 Da

aclK: GT (Score: 506.7; E-value: 1.3e-154)
aknA: KR C9 (Score: 489.1; E-value: 6.5e-150)
aknB: KS (Score: 724.5; E-value: 8e-221)
aknC: CLF 8|9 (Score: 684.9; E-value: 6.9e-209)
aknD: ACP (Score: 108.3; E-value: 3.5e-34)
aknE1: CYC C7-C12 (Score: 519.6; E-value: 5e-159)
aknE2: KSIII (Score: 529.9; E-value: 6e-162); KSIII BAB72048.1_Aklavinone_propionyl-CoA (Score: 729.0; E-value: 0.0)
aknF: AT (Score: 480.1; E-value: 8.3e-147); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 663.0; E-value: 0.0)
aknG: MET carboxy_O (Score: 429.9; E-value: 7e-132)
aknH: CYC C2-C19 (Score: 289.9; E-value: 5.9e-90)