BGC0000192 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000192 (Streptomyces galilaeus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like,T2PKS	1	15,155	High	aclacinomycin	PKS

BGC0000192 - Region 1 - PKS-like,T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 15,155 nt. (total: 15,155 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 15,156
Label		BGC0000192

Tailoring functions

Oxidoreductases: dehydrogenase oxidase

aknA: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

aknOx: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: acylase glycosyltransferase methyltransferase

aknF: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

aknG: methyltransferase

smcogs: SMCOG1089: methyltransferase

aknK: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase dehydratase

aknE1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

aknM: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

aknB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

aknC: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

aknE2: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000192.3	2.00	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000191.5	1.09	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000217.5	0.76	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	0.72	PKS	doxorubicin	Streptomyces peucetius
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.66	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000212.5	0.66	PKS	cinerubin B	Streptomyces sp. SPB074
BGC0002154.2	0.61	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001244.3	0.59	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002175.3	0.58	PKS	YWA1	Aspergillus oryzae RIB40

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000192.3	1.00	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000191.5	0.81	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000217.5	0.70	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	0.69	PKS	doxorubicin	Streptomyces peucetius
BGC0000231.5	0.68	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.66	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000212.5	0.66	PKS	cinerubin B	Streptomyces sp. SPB074
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

aknF: mal

PKS_AT (13..295): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 39.3
Methylmalonyl-CoA: 31.5
Methoxymalonyl-CoA: 30.3
Propionyl-CoA: 22.0
2-Methylbutyryl-CoA: 10.8
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 15155
Starter unit(s):: propionyl-CoA (Score: 1396.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 676.9; E-value: 1.9e-206)
Product class(es):: anthracycline
Product molecular weight(s):: propionyl-CoA_8: 558 Da
propionyl-CoA_9: 600 Da

aknA: KR C9 (Score: 484.8; E-value: 1.3e-148)
aknB: KS (Score: 725.2; E-value: 4.9e-221)
aknC: CLF 8|9 (Score: 676.9; E-value: 1.9e-206)
aknD: ACP (Score: 108.3; E-value: 3.4e-34)
aknE1: CYC C7-C12 (Score: 517.7; E-value: 1.9e-158)
aknE2: KSIII (Score: 528.4; E-value: 1.8e-161); KSIII AAF70109.1_Aclacinomycin_propionyl-CoA (Score: 729.0; E-value: 0.0)
aknF: AT (Score: 480.8; E-value: 5e-147); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 667.0; E-value: 0.0)
aknG: MET carboxy_O (Score: 431.2; E-value: 2.7e-132)
aknH: CYC C2-C19 (Score: 289.9; E-value: 5.9e-90)
aknK: GT (Score: 513.1; E-value: 1.4e-156)