BGC0000195 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000195 (Streptomyces sp. CM020)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	31,030	alnumycin A/alnumycin B/alnumycin C/alnumycin P/prealnumycin/thalnumycin A/thalnumycin B/K1115A/1,6-dihydro-8-propylanthraquinone	PKS:Type II	100%

BGC0000195 - Region 1 - T2PKS

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Location: 1 - 31,030 nt. (total: 31,030 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,031
Label		BGC0000195

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000195	1.00	Polyketide	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000231	0.53	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.30	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723	0.29	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000264	0.29	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0001903	0.25	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002554	0.25	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000866	0.25	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002000	0.24	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000195	1.00	Polyketide	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000231	0.80	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.63	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723	0.63	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000264	0.62	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0001903	0.58	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002554	0.58	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0000866	0.58	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002000	0.58	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

alnK

PKS_AT (9..370): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.2
Methoxymalonyl-CoA: 35.5
Methylmalonyl-CoA: 35.4
inactive: 24.9
Propionyl-CoA: 13.7
2-Methylbutyryl-CoA: 7.6
fatty_acid: 5.5
CHC-CoA: 2.4
Ethylmalonyl-CoA: 1.2
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 31030
Starter unit(s):: butyryl-CoA (Score: 1441.0; E-value: 0)
Malonyl elongations:: 7 (Score: 726.3; E-value: 2e-221)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: butyryl-CoA_7: 353 Da

aln4: KR (Score: 198.1; E-value: 4.8e-61)
alnI: KSIII (Score: 414.6; E-value: 6.8e-127); KSIII ACI88883.1_Alnumycin_butyryl-CoA (Score: 653.0; E-value: 0.0)
alnJ: ACP (Score: 66.7; E-value: 3.2e-21)
alnK: AT (Score: 448.4; E-value: 3.5e-137); AT ACI88860.1_Alnumycin_butyryl-CoA (Score: 788.0; E-value: 0.0)
alnL: KS (Score: 779.0; E-value: 2.3e-237)
alnM: CLF 7 (Score: 726.3; E-value: 2e-221)
alnN: ACP (Score: 103.1; E-value: 1.4e-32)
alnP: KR C9 (Score: 456.6; E-value: 5.3e-140)
alnQ: CYC C7-C12 (Score: 374.8; E-value: 6.1e-115)
alnR: CYC C5-C14 (Score: 488.1; E-value: 1.9e-149)
alnT: OXY (Score: 44.7; E-value: 2.1e-14)