BGC0000195 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000195 (Streptomyces sp. CM020)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	31,030	High	alnumycin A/alnumycin B/alnumycin C/alnumycin P/prealnumycin/thalnumycin A/thalnumycin B/K1115A/1,6-dihydro-8-propylanthraquinone	PKS:Type II

BGC0000195 - Region 1 - T2PKS

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Location: 1 - 31,030 nt. (total: 31,030 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 31,031
Label		BGC0000195

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

aln4: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

alnH: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

alnP: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

alnT: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

Transferases: acylase

alnK: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase

alnB: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase

alnQ: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

alnI: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

alnL: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

alnM: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transport

alnT2: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000195.5	1.00	PKS	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000231.5	0.80	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.63	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0002000.4	0.58	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002047.2	0.56	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000195.5	1.00	PKS	alnumycin A, alnumycin B, alnumycin C, alnumycin P, prealnumycin, thalnumycin A, thalnumycin B, K1115A, 1,6-dihydro-8-propylanthraquinone	Streptomyces sp. CM020
BGC0000231.5	0.80	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.63	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0002000.4	0.58	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002047.2	0.56	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

alnK: mal

PKS_AT (9..370): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; inactive: 62.5%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 86.2
Methoxymalonyl-CoA: 35.5
Methylmalonyl-CoA: 35.4
inactive: 24.9
Propionyl-CoA: 13.7
2-Methylbutyryl-CoA: 7.6
fatty_acid: 5.5
CHC-CoA: 2.4
Ethylmalonyl-CoA: 1.2
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 31030
Starter unit(s):: butyryl-CoA (Score: 1441.0; E-value: 0)
Malonyl elongations:: 7 (Score: 726.3; E-value: 2e-221)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: butyryl-CoA_7: 353 Da

aln4: KR (Score: 198.1; E-value: 4.8e-61)
alnI: KSIII (Score: 414.6; E-value: 6.8e-127); KSIII ACI88883.1_Alnumycin_butyryl-CoA (Score: 653.0; E-value: 0.0)
alnJ: ACP (Score: 66.7; E-value: 3.2e-21)
alnK: AT (Score: 448.4; E-value: 3.5e-137); AT ACI88860.1_Alnumycin_butyryl-CoA (Score: 788.0; E-value: 0.0)
alnL: KS (Score: 779.0; E-value: 2.3e-237)
alnM: CLF 7 (Score: 726.3; E-value: 2e-221)
alnN: ACP (Score: 103.1; E-value: 1.4e-32)
alnP: KR C9 (Score: 456.6; E-value: 5.3e-140)
alnQ: CYC C7-C12 (Score: 374.8; E-value: 6.1e-115)
alnR: CYC C5-C14 (Score: 488.1; E-value: 1.9e-149)
alnT: OXY (Score: 44.7; E-value: 2.1e-14)