Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000195.1:
Cluster 1Polyketide131030

BGC0000195, alnumycin biosynthetic gene cluster from Streptomyces sp. CM020. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: alnumycin A
SMILES string: Copy to clipboard
Molecular formula: C22H25O8
Exact molecular mass: 416 Da (M-)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Butyryl-ACP
Polyketide synthase / ketosynthase-encoding genes:
ACI88861.1
Genes involved in folding/cyclization:
ACI88864.1,ACI88865.1,ACI88866.1

Gene cluster description

alnumycin (BGC0000195). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank EU852062. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Mikko Metsa-Ketela (University of Turku)

Literature references

1. Oja T et al. (2008) Characterization of the alnumycin gene cluster reveals unusual gene products for pyran ring formation and dioxan biosynthesis. Chem Biol 15(10):1046-57. doi: 10.1016/j.chembiol.2008.07.022.
2. Grocholski T et al. (2012) Characterization of the two-component monooxygenase system AlnT/AlnH reveals early timing of quinone formation in alnumycin biosynthesis. J Bacteriol 194(11):2829-36. doi: 10.1128/JB.00228-12. Epub 2012 Mar
3. Oja T et al. (2012) Biosynthetic pathway toward carbohydrate-like moieties of alnumycins contains unusual steps for C-C bond formation and cleavage. Proc Natl Acad Sci U S A 109(16):6024-9. doi:
4. Oja T et al. (2013) Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway. Proc Natl Acad Sci U S A 110(4):1291-6. doi: