BGC0000195: alnumycin A biosynthetic gene cluster from Streptomyces sp. CM020
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Location: 1 - 31,030 nt. (total: 31,030 nt).
This entry is originally from NCBI GenBank EU852062.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000195
Short description alnumycin A biosynthetic gene cluster from Streptomyces sp. CM020
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
EU852062.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • alnumycin A
  • alnumycin B
  • alnumycin C
  • alnumycin P
  • prealnumycin
  • thalnumycin A
  • thalnumycin B
  • K1115A
  • 1,6-dihydro-8-propylanthraquinone
Species Streptomyces sp. CM020 [taxonomy]
References
Chemical products information
alnumycin A Evidence:
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C22H24O8
alnumycin B Evidence:
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C22H22O8
alnumycin C Evidence:
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C22H24O8
alnumycin P Evidence:
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C22H23O11P1
prealnumycin Evidence:
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C17H16O4
thalnumycin A Evidence:
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C17H18O4
thalnumycin B Evidence:
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C17H18O5
K1115A Evidence:
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C18H14O6
1,6-dihydro-8-propylanthraquinone Evidence:
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C17H14O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACI88856.1
  • alnR1
 7 - 513 (+) AlnR1
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    • ACI88857.1
    • aln1
    		 483 - 1178 (-) Aln1
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      • ACI88858.1
      • aln2
      		 1183 - 1701 (-) Aln2
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        • ACI88859.1
        • alnJ
        		 1823 - 2077 (+) AlnJ starter unit acyl carrier protein
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          • ACI88860.1
          • alnK
          		 2059 - 3303 (-) AlnK starter unit acyl transferase
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            • ACI88861.1
            • alnL
            		 3481 - 4746 (+) AlnL ketoacyl synthase alpha
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              • ACI88862.1
              • alnM
              		 4743 - 6029 (+) AlnM ketoacyl synthase beta
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                • ACI88863.1
                • alnN
                		 6116 - 6370 (+) AlnN acyl carrier protein
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                  • ACI88864.1
                  • alnP
                  		 6389 - 7180 (+) AlnP ketoreductase
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                    • ACI88865.1
                    • alnQ
                    		 7238 - 8233 (+) AlnQ aromatase
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                      • ACI88866.1
                      • alnR
                      		 8245 - 9180 (+) AlnR cyclase
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                        • ACI88867.1
                        • alnT
                        		 9372 - 10613 (-) quinone forming FMN-dependent mono-oxygenase
                        • Tailoring
                        • Knock-out Activity assay
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                        • ACI88868.1
                        • alnR2
                        		 10681 - 11277 (-) AlnR2 TetR family regulator
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                          • ACI88869.1
                          • aln3
                          		 11401 - 11868 (+) Aln3
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                            • ACI88870.1
                            • aln4
                            		 11872 - 12936 (+) alnumycin B aldoreductase
                            • Tailoring
                            • Knock-out Activity assay
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                            • ACI88871.1
                            • alnO
                            		 13052 - 13510 (-) AlnO
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                              • ACI88872.1
                              • aln5
                              		 13510 - 14040 (-) Aln5
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                                • ACI88873.1
                                • aln6
                                		 14037 - 15116 (-) alnumycin C oxidase
                                • Tailoring
                                • Knock-out Activity assay
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                                • ACI88874.1
                                • alnB
                                		 15197 - 15880 (-) alnumycin P phosphatase
                                • Tailoring
                                • Knock-out Activity assay
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                                • ACI88875.1
                                • alnA
                                		 15877 - 16797 (-) prealnumycin C-ribosylase
                                • Tailoring
                                • Knock-out Activity assay
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                                • ACI88876.1
                                • aln7
                                		 16988 - 18046 (+) Aln7
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                                  • ACI88877.1
                                  • alnR3
                                  		 18194 - 19009 (-) AlnR3 SARP family regulator
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                                    • ACI88878.1
                                    • aln8
                                    		 19359 - 19916 (-) Aln8
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                                      • ACI88879.1
                                      • alnT1
                                      		 20218 - 21759 (-) AlnT1 transporter
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                                        • ACI88880.1
                                        • alnR8
                                        		 21851 - 22351 (+) AlnR8 MarR family regulator
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                                          • ACI88881.1
                                          • alnR4
                                          		 22454 - 23746 (+) AlnR4 two component sensory kinase
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                                            • ACI88882.1
                                            • alnR5
                                            		 23769 - 24374 (-) AlnR5 two component response regulator
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                                              • ACI88883.1
                                              • alnI
                                              		 24879 - 25877 (+) AlnI starter unit ketoacyl synthase
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                                                • ACI88884.1
                                                • alnH
                                                		 25874 - 26416 (+) flacin reductase
                                                • Activation / processing
                                                • Knock-out
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                                                • ACI88885.1
                                                • alnR6
                                                		 26434 - 27090 (-) AlnR6 two component response regulator
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                                                  • ACI88886.1
                                                  • alnR7
                                                  		 27087 - 28232 (-) AlnR7 two component sensory kinase
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                                                    • ACI88887.1
                                                    • alnT2
                                                    		 28667 - 30892 (-) AlnT2 transporter
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                                                      Biosynthesis information
                                                      Annotation changelog

                                                      Entry version: 4

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-10-07
                                                      Update chemical activity to schema version 2.11
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 3

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2022-09-15
                                                      Cleaned up synonym list
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      2022-09-15
                                                      Updated bioactivity data
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 2

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2019-10-16
                                                      Migrated from v1.4
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                      Entry version: 1

                                                      Date
                                                      Changes
                                                      Submitters
                                                      Reviewers
                                                      2015-06-12
                                                      Submitted
                                                      • (ID: HSOJFFPY5IUT4HBQLSN7DGJX)
                                                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                      Detailed domain annotation
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