BGC0000195: alnumycin A biosynthetic gene cluster from Streptomyces sp. CM020
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Location: 1 - 31,030 nt. (total: 31,030 nt).
This entry is originally from NCBI GenBank EU852062.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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Polyketide
History
NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000195
Short description alnumycin A biosynthetic gene cluster from Streptomyces sp. CM020
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: EU852062.1
Compounds
  • alnumycin A
  • alnumycin B
  • alnumycin C
  • alnumycin P
  • prealnumycin
  • thalnumycin A
  • thalnumycin B
  • K1115A
  • 1,6-dihydro-8-propylanthraquinone
Species Streptomyces sp. CM020 [taxonomy]
References
Chemical products information
alnumycin A
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C22H24O8
alnumycin B
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C22H22O8
alnumycin C [synonyms: anhydroexfoliamycin]
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C22H24O8
alnumycin P
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C22H23O11P1
prealnumycin
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C17H16O4
thalnumycin A
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C17H18O4
thalnumycin B
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C17H18O5
K1115A
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C18H14O6
1,6-dihydro-8-propylanthraquinone
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C17H14O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACI88856.1
  • alnR1
 7 - 513 (+) AlnR1
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  • ACI88857.1
  • aln1
 483 - 1178 (-) Aln1
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  • ACI88858.1
  • aln2
 1183 - 1701 (-) Aln2
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  • ACI88859.1
  • alnJ
 1823 - 2077 (+) AlnJ starter unit acyl carrier protein
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  • ACI88860.1
  • alnK
 2059 - 3303 (-) AlnK starter unit acyl transferase
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  • ACI88861.1
  • alnL
 3481 - 4746 (+) AlnL ketoacyl synthase alpha
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  • ACI88862.1
  • alnM
 4743 - 6029 (+) AlnM ketoacyl synthase beta
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  • ACI88863.1
  • alnN
 6116 - 6370 (+) AlnN acyl carrier protein
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  • ACI88864.1
  • alnP
 6389 - 7180 (+) AlnP ketoreductase
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  • ACI88865.1
  • alnQ
 7238 - 8233 (+) AlnQ aromatase
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  • ACI88866.1
  • alnR
 8245 - 9180 (+) AlnR cyclase
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  • ACI88867.1
  • alnT
 9372 - 10613 (-) quinone forming FMN-dependent mono-oxygenase
  • Tailoring (Oxidation)
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  • ACI88868.1
  • alnR2
 10681 - 11277 (-) AlnR2 TetR family regulator
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  • ACI88869.1
  • aln3
 11401 - 11868 (+) Aln3
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  • ACI88870.1
  • aln4
 11872 - 12936 (+) alnumycin B aldoreductase
  • Tailoring (Reduction)
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  • ACI88871.1
  • alnO
 13052 - 13510 (-) AlnO
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  • ACI88872.1
  • aln5
 13510 - 14040 (-) Aln5
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  • ACI88873.1
  • aln6
 14037 - 15116 (-) alnumycin C oxidase
  • Tailoring (Oxidation)
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  • ACI88874.1
  • alnB
 15197 - 15880 (-) alnumycin P phosphatase
  • Tailoring (Unknown)
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  • ACI88875.1
  • alnA
 15877 - 16797 (-) prealnumycin C-ribosylase
  • Tailoring (Glycosylation)
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  • ACI88876.1
  • aln7
 16988 - 18046 (+) Aln7
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  • ACI88877.1
  • alnR3
 18194 - 19009 (-) AlnR3 SARP family regulator
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  • ACI88878.1
  • aln8
 19359 - 19916 (-) Aln8
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  • ACI88879.1
  • alnT1
 20218 - 21759 (-) AlnT1 transporter
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  • ACI88880.1
  • alnR8
 21851 - 22351 (+) AlnR8 MarR family regulator
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  • ACI88881.1
  • alnR4
 22454 - 23746 (+) AlnR4 two component sensory kinase
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  • ACI88882.1
  • alnR5
 23769 - 24374 (-) AlnR5 two component response regulator
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  • ACI88883.1
  • alnI
 24879 - 25877 (+) AlnI starter unit ketoacyl synthase
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  • ACI88884.1
  • alnH
 25874 - 26416 (+) flacin reductase
  • Activation / processing
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  • ACI88885.1
  • alnR6
 26434 - 27090 (-) AlnR6 two component response regulator
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  • ACI88886.1
  • alnR7
 27087 - 28232 (-) AlnR7 two component sensory kinase
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  • ACI88887.1
  • alnT2
 28667 - 30892 (-) AlnT2 transporter
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Polyketide-specific information
Subclass Other
Starter unit Butyryl-ACP
Ketide length 8
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
alnP
+
alnQ
+
alnL
+
alnR 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: HSOJFFPY5IUT4HBQLSN7DGJX, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Cleaned up synonym list
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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