LOCUS       BGC0000196              9994 bp    DNA     linear   CON 27-FEB-2015
DEFINITION  Photorhabdus luminescens subsp. laumondii TTO1 complete genome.
ACCESSION   BGC0000196
VERSION     BGC0000196
KEYWORDS    .
SOURCE      Photorhabdus laumondii subsp. laumondii TTO1
  ORGANISM  Photorhabdus laumondii subsp. laumondii TTO1
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Morganellaceae; Photorhabdus.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 17:40:28
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 9994
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     subregion       1..9994
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000196"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..9994
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      complement(11..16)
                     /locus_tag="plu4185"
                     /regulatory_class="ribosome_binding_site"
     CDS             complement(954..2108)
                     /codon_start=1
                     /db_xref="InterPro:IPR029058"
                     /db_xref="InterPro:IPR029059"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT8"
                     /function="Unknown, putative endopeptidase"
                     /locus_tag="plu4186"
                     /note="unnamed protein product; Weakly similar to unknown
                     protein"
                     /protein_id="CAE16558.1"
                     /transl_table=11
                     /translation="MNNKNKPNRISPELLATCGYFMPRIFFLNSQYAPQVHWGDVVAAL
                     SHFPAGNLDLSSEEFWYEWMINWSKVGDSYINIANSAKSEVSHVRALRSAAACYHWAEF
                     MYFSDRSRKIQLREYIRSCFLSSIKYSDLLVDHQYIVVDKFHMPFFLIFPKGYKEEENH
                     PLPCVILSNGLDSMTEIEILSLAEFFLGKNMAVAIFDGPGQGINLGKSPIAIDMELYVS
                     SIVKLLEDDARINSNLLCFLGISFGGYFALRVAQRIGDKFCCIVNLSGGPEIAEFDKLP
                     RRLKEDFQFAFMQDNSHMQSIFDEIKLDISLPCKTKVFTVHGELDDIFQIDKVKKLDQL
                     WGDNHQLLCYESEAHVCLNKINEYMIQVSDWVSEQFWLNGYKKG"
     gene            complement(954..2119)
                     /locus_tag="plu4186"
     regulatory      complement(2114..2119)
                     /locus_tag="plu4186"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(2128..3570)
                     /locus_tag="plu4187"
     CDS             complement(2128..3570)
                     /NRPS_PKS="Domain: Polyketide_cyc (11-115). E-value:
                     2.4e-08. Score: 26.1. Matches aSDomain:
                     nrpspksdomains_plu4187_Polyketide_cyc.1"
                     /NRPS_PKS="Domain: Polyketide_cyc (174-297). E-value:
                     4.8e-16. Score: 51.0. Matches aSDomain:
                     nrpspksdomains_plu4187_Polyketide_cyc.2"
                     /NRPS_PKS="Domain: Polyketide_cyc (333-453). E-value:
                     1.6e-13. Score: 42.8. Matches aSDomain:
                     nrpspksdomains_plu4187_Polyketide_cyc.3"
                     /codon_start=1
                     /db_xref="InterPro:IPR005031"
                     /db_xref="InterPro:IPR023393"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT7"
                     /function="Unknown"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 283.3; E-value:
                     4.1e-86)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="plu4187"
                     /note="unnamed protein product; Some similarities with
                     cyclase/dehydrase/aromatase"
                     /protein_id="CAE16559.1"
                     /transl_table=11
                     /translation="MNYVESHSIICNAQIEDVYEIIINSDKWPGMFEPCQEVKTLFRDK
                     EGEKIEIKALINGILMQWESNRKFYPETFSIKSKLNPPMTLVKEMETSWRVIKINSQQC
                     VLLLEHLYDLESEVAGLIDGVETIEQAHQFISKAIDTNSVKELNNIKNIVESTEGSEKV
                     LTGTITHSVVCEVPAQQVYTLVKDVSCWTGIFSFCDGAEVLKRSGNEELVEIKAKQNNK
                     AVSWQTQRYYFDTIYRVDYVMPTPMPLLKTMNGRWQIIPINDQRCILTVQRNWGLLEDV
                     SGIVDGIDNHDQANSFIISFINDNTRMEMDSIKSQVESHKKSNLLTFSAGYYIPHQVDD
                     VYKIFLNIDDWSKILPHCDSVKVIYNDDKHQEFNMEVSTPNGNETFRSIRFCDVDNLLI
                     EYFQPEPPLVLKSHSGSWQILSKGSGSYIVSSHDVELNYELCAVKFGTEDKEKQREIVK
                     NAISENSKKMVFACKEWLDTRI"
     aSDomain        complement(2212..2571)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4187_Polyketide_cyc.3"
                     /domain_subtype="Polyketide_cyc"
                     /evalue="1.60E-13"
                     /label="plu4187_Polyketide_cyc.3"
                     /locus_tag="plu4187"
                     /protein_end="453"
                     /protein_start="333"
                     /score="42.8"
                     /tool="antismash"
                     /translation="IPHQVDDVYKIFLNIDDWSKILPHCDSVKVIYNDDKHQEFNMEVS
                     TPNGNETFRSIRFCDVDNLLIEYFQPEPPLVLKSHSGSWQILSKGSGSYIVSSHDVELN
                     YELCAVKFGTEDKEKQ"
     aSModule        2212..3537
                     /domains="nrpspksdomains_plu4187_Polyketide_cyc.1"
                     /domains="nrpspksdomains_plu4187_Polyketide_cyc.2"
                     /domains="nrpspksdomains_plu4187_Polyketide_cyc.3"
                     /incomplete
                     /locus_tags="plu4187"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        complement(2680..3048)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4187_Polyketide_cyc.2"
                     /domain_subtype="Polyketide_cyc"
                     /evalue="4.80E-16"
                     /label="plu4187_Polyketide_cyc.2"
                     /locus_tag="plu4187"
                     /protein_end="297"
                     /protein_start="174"
                     /score="51.0"
                     /tool="antismash"
                     /translation="EVPAQQVYTLVKDVSCWTGIFSFCDGAEVLKRSGNEELVEIKAKQ
                     NNKAVSWQTQRYYFDTIYRVDYVMPTPMPLLKTMNGRWQIIPINDQRCILTVQRNWGLL
                     EDVSGIVDGIDNHDQANSF"
     aSDomain        complement(3226..3537)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4187_Polyketide_cyc.1"
                     /domain_subtype="Polyketide_cyc"
                     /evalue="2.40E-08"
                     /label="plu4187_Polyketide_cyc.1"
                     /locus_tag="plu4187"
                     /protein_end="115"
                     /protein_start="11"
                     /score="26.1"
                     /tool="antismash"
                     /translation="NAQIEDVYEIIINSDKWPGMFEPCQEVKTLFRDKEGEKIEIKALI
                     NGILMQWESNRKFYPETFSIKSKLNPPMTLVKEMETSWRVIKINSQQCVLLLEHLYDLE
                     "
     gene            complement(3570..5117)
                     /locus_tag="plu4188"
     CDS             complement(3570..5117)
                     /NRPS_PKS="Domain: AMP-binding (17-400). E-value: 2.4e-48.
                     Score: 156.5. Matches aSDomain:
                     nrpspksdomains_plu4188_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:Q7MZT6"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR020845"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT6"
                     /function="Unknown"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     162.6; E-value: 2e-49)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="plu4188"
                     /note="unnamed protein product; Some similarities with
                     long-chain acyl-CoA synthetase (ligase)"
                     /protein_id="CAE16560.1"
                     /transl_table=11
                     /translation="MKLISMLLHSGRDNLHHDCIITKDYHYTRKEVISSVSHLIDDLLS
                     RGVQKGSKVIVIFEHDELGIFFLAAASAMGLHLLMPYNLSSATIDEWINFTNEVQYDFV
                     VYLKKDKHFVGRLKENNINVIDISDHKIRVSDDIAEIPIITYSPQSIANFIVLFTSGST
                     GKPKAISISESLVCRRIYSVTEKLKFTQDAKIFMSGLLNNTTGVIFSFGSLLHQSTLFI
                     PEDRNVERWPDYLSRNKITHIMLRPESMKLFVKSTAEHNIDLSDLQVVAYGAAAMPPSV
                     LEKGRQLIGCEWMQGYGLSETYGPFCWVDEQDHRDKRYLNSIYCVGKIDNTLAVAVKPI
                     IGSSDNIGEIIIRGESIMEGYYDVLSGEITPPDEWFATGDLGYIDEEGYLVLKGRKQNT
                     FMSANGHRIYPEEVESILSRIPNVNVATVVGFSFHENGVAIDQPVACMSGEISKKSLPE
                     IEDIISSFLSRKLSREKWPDWFYVTDEYFPKSHNDKILKAELIKSIDPKKLFTLRNQ"
     regulatory      complement(3579..3584)
                     /locus_tag="plu4187"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(3579..3584)
                     /locus_tag="plu4187"
     aSDomain        complement(3918..5066)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4188_AMP-binding.1"
                     /evalue="2.40E-48"
                     /label="plu4188_AMP-binding.1"
                     /locus_tag="plu4188"
                     /protein_end="400"
                     /protein_start="17"
                     /score="156.5"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="DCIITKDYHYTRKEVISSVSHLIDDLLSRGVQKGSKVIVIFEHDE
                     LGIFFLAAASAMGLHLLMPYNLSSATIDEWINFTNEVQYDFVVYLKKDKHFVGRLKENN
                     INVIDISDHKIRVSDDIAEIPIITYSPQSIANFIVLFTSGSTGKPKAISISESLVCRRI
                     YSVTEKLKFTQDAKIFMSGLLNNTTGVIFSFGSLLHQSTLFIPEDRNVERWPDYLSRNK
                     ITHIMLRPESMKLFVKSTAEHNIDLSDLQVVAYGAAAMPPSVLEKGRQLIGCEWMQGYG
                     LSETYGPFCWVDEQDHRDKRYLNSIYCVGKIDNTLAVAVKPIIGSSDNIGEIIIRGESI
                     MEGYYDVLSGEITPPDEWFATGDLGYIDEEGYLVLKGRKQNTF"
     CDS_motif       complement(4602..4652)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_plu4188_0001"
                     /evalue="1.70E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="plu4188"
                     /protein_end="172"
                     /protein_start="155"
                     /score="20.6"
                     /tool="antismash"
                     /translation="VLFTSGSTGKPKAISIS"
     CDS             complement(5141..5389)
                     /NRPS_PKS="Domain: PP-binding (7-73). E-value: 6.5e-12.
                     Score: 37.7. Matches aSDomain:
                     nrpspksdomains_plu4189_PP-binding.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT5"
                     /function="Unknown"
                     /locus_tag="plu4189"
                     /note="unnamed protein product; Hypothetical gene"
                     /protein_id="CAE16561.1"
                     /transl_table=11
                     /translation="MNNHPEVKIKTILSLFLNINIDDFNMDANLADAYDMDSTELADLA
                     KEIEKEFGISVTKSQFSHWETGRAVLDFVSSSLNDKN"
     gene            complement(5141..5403)
                     /locus_tag="plu4189"
     aSDomain        complement(5171..5368)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4189_PP-binding.1"
                     /evalue="6.50E-12"
                     /label="plu4189_PP-binding.1"
                     /locus_tag="plu4189"
                     /protein_end="73"
                     /protein_start="7"
                     /score="37.7"
                     /tool="antismash"
                     /translation="KIKTILSLFLNINIDDFNMDANLADAYDMDSTELADLAKEIEKEF
                     GISVTKSQFSHWETGRAVLDF"
     regulatory      complement(5398..5403)
                     /locus_tag="plu4189"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(5424..6539)
                     /locus_tag="plu4190"
     CDS             complement(5424..6539)
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (31-245). E-value:
                     6.2e-14. Score: 43.5. Matches aSDomain:
                     nrpspksdomains_plu4190_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:Q7MZT4"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT4"
                     /function="Unknown"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 134.5; E-value:
                     6.7e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="plu4190"
                     /note="unnamed protein product; Some similarities with the
                     N-terminal region of 3-oxoacyl-[acyl-carrier-protein]
                     synthase"
                     /protein_id="CAE16562.1"
                     /transl_table=11
                     /translation="MRKRVVVTGVGAIHPDGNDVTAIKSKVIQKLLGQESKNNTTASSI
                     IRTLSDFDGAKYINNRLRRKIDEFSVYGIVAVEMALKASRLDVDKLDPNRVGIYVGNCF
                     GGWQHIEDEVKALHIEGIKGMGPYVATAWFPAALQGQLSLLYGFSAQSKTFSTSDVAGM
                     QAIGYAAEAISNGVAEVMLCGASEHLSSPLVKNLLEKTSSQKHSEVFGEKQPGDFSEGA
                     AFLVLEERQHALERGASILCELTGFVDYFAPDKNTRNNTLEYTAELFNHNENAVFIMDG
                     IYDDEKEITSKAFSNKEIKTSFINLRPYLDNQFSVSGVIDSVLASSFLSESHGDEEQQS
                     KKINEFSNTNQIIIQRFSNQGHVCALSFSAI"
     aSDomain        complement(5805..6446)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4190_PKS_KS.1"
                     /domain_subtype="Modular-KS"
                     /evalue="6.20E-14"
                     /label="plu4190_PKS_KS.1"
                     /locus_tag="plu4190"
                     /protein_end="245"
                     /protein_start="31"
                     /score="43.5"
                     /tool="antismash"
                     /translation="LGQESKNNTTASSIIRTLSDFDGAKYINNRLRRKIDEFSVYGIVA
                     VEMALKASRLDVDKLDPNRVGIYVGNCFGGWQHIEDEVKALHIEGIKGMGPYVATAWFP
                     AALQGQLSLLYGFSAQSKTFSTSDVAGMQAIGYAAEAISNGVAEVMLCGASEHLSSPLV
                     KNLLEKTSSQKHSEVFGEKQPGDFSEGAAFLVLEERQHALERGASILCELT"
     gene            complement(6532..7818)
                     /locus_tag="plu4191"
     CDS             complement(6532..7818)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (84-395). E-value:
                     3.3e-39. Score: 126.8. Matches aSDomain:
                     nrpspksdomains_plu4191_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:Q7MZT3"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT3"
                     /function="Unknown, probably involved in antibiotique
                     biosynthesis"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 337.6; E-value:
                     1.9e-102)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="plu4191"
                     /note="unnamed protein product; Similar to polyketide
                     beta-ketoacyl synthase"
                     /protein_id="CAE16563.1"
                     /transl_table=11
                     /translation="MIINNRNESQPRRVVVTGLGVVAPTGVGVNEFWNNIHNGKSGVSK
                     YEWGRERFGFKSGAIGQVYGSDGNNKEFVLKSERKYLQFALDAAEMAMQDANLRPSDID
                     GRRFGVAIATAIADAAGMEECLLRITKGGKENIHPDLIKSEDYDSFDFSSAATSVAKKY
                     GASMSVSNISTGCAAGLDALGIAMEHIRYGRADIMLAGASEAPLCPLSIGSFEALGALS
                     SRELENQQAATCPFSLERDGFVIAEGCGILILESYEHAKQRGAHIYAELAGYASVNNAY
                     HMTDLPADGMAMARCIDMALKDAQISPSTVNYISAHGSSTAQNDINESNAIKFVLGESA
                     FGIPINSLKSMTGHALAAANAIESVALCLEIEKQYVHPTINYQTPDPDCDLDYIPNQGC
                     SYPIKTALKLSSGFSGIHSVIVMRAVDNA"
     regulatory      complement(6550..6555)
                     /locus_tag="plu4190"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(6550..6555)
                     /locus_tag="plu4190"
     aSDomain        complement(6634..7566)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_plu4191_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="3.30E-39"
                     /label="plu4191_PKS_KS.1"
                     /locus_tag="plu4191"
                     /protein_end="395"
                     /protein_start="84"
                     /score="126.8"
                     /tool="antismash"
                     /translation="ALDAAEMAMQDANLRPSDIDGRRFGVAIATAIADAAGMEECLLRI
                     TKGGKENIHPDLIKSEDYDSFDFSSAATSVAKKYGASMSVSNISTGCAAGLDALGIAME
                     HIRYGRADIMLAGASEAPLCPLSIGSFEALGALSSRELENQQAATCPFSLERDGFVIAE
                     GCGILILESYEHAKQRGAHIYAELAGYASVNNAYHMTDLPADGMAMARCIDMALKDAQI
                     SPSTVNYISAHGSSTAQNDINESNAIKFVLGESAFGIPINSLKSMTGHALAAANAIESV
                     ALCLEIEKQYVHPTINYQTPDPDCDLDYIP"
     gene            complement(8470..9285)
                     /locus_tag="plu4192"
     CDS             complement(8470..9285)
                     /codon_start=1
                     /db_xref="GOA:Q7MZT2"
                     /db_xref="InterPro:IPR007325"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT2"
                     /function="Unknown, probably involved in antibiotique
                     biosynthesis"
                     /locus_tag="plu4192"
                     /note="unnamed protein product; Similar to polyketide
                     cyclase"
                     /protein_id="CAE16564.1"
                     /transl_table=11
                     /translation="MSNIIDLSVPIDCDFWEPEKVTRGVVDHKEGANKLGESYLYFHTN
                     SWWKRAFVKLFKRKKWIIDHNDFPDGMGLSLMYYRLTTHTGTHIDAPYHYGWHKGQDQP
                     ATITDIPLDWFYSHGVLLDFSHDNQSIDKQAVENQLKKINYKIKENDIVLINTGADKLL
                     GEKSYFTHYKAIESSAVQWLVEQGVKIIGTDAFSFDRPFIEMINDYKKTGNKDCLWPSH
                     FIGRDHPYLQIERLCNLTSIPKPYGFKVCCFPIKLEKADASWSRVVAIL"
     gene            complement(9278..9991)
                     /locus_tag="plu4193"
     CDS             complement(9278..9991)
                     /codon_start=1
                     /db_xref="GOA:Q7MZT1"
                     /db_xref="InterPro:IPR008278"
                     /db_xref="UniProtKB/TrEMBL:Q7MZT1"
                     /function="Unknown, probably involved in antibiotique
                     biosynthesis"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 75.5;
                     E-value: 5.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="plu4193"
                     /note="unnamed protein product; Some similarities with
                     antibiotics biosynthesis protein"
                     /protein_id="CAE16565.1"
                     /transl_table=11
                     /translation="MDDISLSSDFSDLWIIKIDDIDLSSIEQLIHRSDIVRHNQICLAD
                     RRKKFIFRRAALRYVLNQYLSDYEIITNDNGKPYISTEQDFKYYFSLSASGNYCAIGFS
                     SREIGVDIEVTPSKIKFSEIIERFIKDKELEYIKGIMLKQLSGVSPGFKNYYHLMSLYC
                     WVRLEAYIKLFASTLHEKLLANNSDSVKDMKELEASTLLIHHQQFVCALSQKKVISTPN
                     IKEINYFEIIRNKDE"
     regulatory      complement(9293..9298)
                     /locus_tag="plu4192"
                     /regulatory_class="ribosome_binding_site"
     gene            complement(9293..9298)
                     /locus_tag="plu4192"
ORIGIN
        1 tttccgaact cctcatttta ataaaaatta aataggataa ggttttactg aataaataat
       61 attgcgttac tagctagtta cccaatatat ccgtcatctt tcaagttgcc tctttgttgg
      121 ctgcactctc tcaccccgcc cacatcgtta tctatgctcc cggggattcg ctcccttgcc
      181 gtcgcaatcc atcttgaaat ccatagggta taactatcta ttcttaatta tctattatgg
      241 aacaatatcg agatttctct ataaaaccat caactcgaaa tcctatactt aatatagacc
      301 tcaattgtca ggattgacga aaatgctatt gccgtcttac ataattacca aactctgtca
      361 agagtaaatg ttcaatgcat tacgccgaaa caaggttaaa gtaaatatcg aacatcaaac
      421 atagcgcaaa tatttaaaat tttaatatac tgctaattaa tacaaaaaat aaaacttaca
      481 ctcaacaaga taacttatca taagtaaatt tactatgtat taatgatata agaaaacaca
      541 aatattaaag tcaattttca tactgccagt taatacctca gcagaaaaat tatggcttta
      601 ttattctgac atatcgcttc gtaatgcctg ggaagatgtt ttgattttat tactaatgta
      661 aaatagcagt ggaactaaaa ggcataccca aataggttta accttaactt ctgttgaaaa
      721 aataaatttc tttagacaag atgaataatc cctagcttat ctttaattta tttttaatat
      781 cgaataacaa tatctcaatt ggttaataac tttatgatct atacccgtta tcattcaagt
      841 tgcctctttg ttggctgcac tctctcaccc cggtcacata gttctctatg ctcccgggga
      901 ttctctccct taccatcgcg atgtatattg aaatccattg ggtataaaat caattaacct
      961 tttttatagc catttagcca aaattgttca ctaacccaat ctgaaacttg tatcatatat
     1021 tcgtttattt tatttaagca aacatgagcc tctgattcat aacataataa ctggtgatta
     1081 tcaccccata gttgatctaa ttttttcact ttatcgatct gaaatatatc atctaattca
     1141 ccatgaacag taaaaacctt ggttttacaa ggtaaagaga tgtccaattt aatttcgtca
     1201 aaaatagact gcatatgact attatcttgc ataaatgcaa actggaaatc ttctttaagc
     1261 cttcttggca acttatcaaa ctctgctatt tcaggcccac cggataaatt gacgatacaa
     1321 caaaatttat cgccaattct ttgcgcaacg cgtagagcaa aataaccacc aaaactaatt
     1381 cctaagaaac aaagaagatt actattaatt cgggcatcat cttctaataa tttaactata
     1441 gagctaacat ataattccat atcaatagct attggtgatt tcccaagatt tattccctgc
     1501 cctggtccat caaatatagc taccgccata tttttcccta agaaaaactc ggccaaagat
     1561 aatatttcaa tttcagtcat tgaatccaat ccattggata aaataacaca aggcaaagga
     1621 tgattctctt cttctttata ccctttaggg aatataagga agaacggcat atgaaattta
     1681 tcgacgacaa tatattggtg gtcaaccagc aaatcactat attttatact agataaaaaa
     1741 catgaacgaa tatactctct gagctgtatc tttctactcc tatcactaaa atacataaat
     1801 tctgcccaat gataacaggc agcggcactc ctcaaagcac gaacatgact aacttcactc
     1861 ttagccgagt tagcgatatt aatatagcta tcacccactt ttgaccaatt aatcatccat
     1921 tcataccaaa actcttcaga ggataagtct aagtttcccg ctggaaaatg actcaatgcc
     1981 gcaacaacat ctccccaatg aacttgggga gcatattgag aatttaagaa gaatattctt
     2041 ggcataaaat aaccacaagt agcaagaagt tctggcgaaa ttctattggg tttattttta
     2101 ttattcatct tattttcctt taagttacta aatacgagtg tctaaccact ctttgcaagc
     2161 aaaaaccatt tttttactat tttctgaaat agcatttttt actatctctc gttgtttttc
     2221 tttatcttcc gtaccaaatt taactgcaca taattcataa tttaactcaa catcatggct
     2281 agaaacaatg tacgaaccac tccctttact caatatctgc catgaaccac tatgagactt
     2341 taatactaaa ggcggctctg gttgaaaata ttcaatcaat aaattatcca catcacagaa
     2401 tcgtatacta cggaaagtct catttccatt tggtgttgat acttccatat taaattcttg
     2461 atgtttatca tcattataaa tgacttttac tgaatcacaa tgcggtaata tcttgctcca
     2521 gtcatcgata tttaaaaaga tcttataaac atcatcaacc tgatgaggaa tataatatcc
     2581 cgctgagaaa gttaataaat ttgatttttt atgactttct acctgactct ttatactatc
     2641 catctccatt cgagtattat cattgataaa tgagataata aaggaattag cctggtcatg
     2701 attatcaata ccatcaacga taccactgac atcttctaat aaaccccagt tcctttgtac
     2761 cgttagaata cagcgttgat cattaatagg aataatttgc catctgccat tcattgtttt
     2821 taataatggc atcggtgtag gcataacata atcaacccgg taaatagtat caaaataata
     2881 tcgctgcgtt tgccaactta ctgctttatt attttgtttt gctttgattt caactaattc
     2941 ttcattacct gatctcttta aaacttctgc accatcacag aatgaaaaaa tacctgtcca
     3001 acaagagaca tctttaacta aagtataaac ctgctgtgcc ggcacctcac atacgactga
     3061 atgagtaatc gttcctgtta atactttttc cgatccctcc gttgattcga cgatattttt
     3121 tatattattg agctctttaa ctgaattggt atcaatagct ttactaataa attggtgcgc
     3181 ctgctctatt gtttcaacac catcaattaa cccggctact tcagactcaa gatcatataa
     3241 atgctccaac aacagtacac attgctgaga attgatttta attacgcgcc atgacgtttc
     3301 catttcttta actaatgtca ttgggggatt cagttttgat tttatactga atgtttctgg
     3361 ataaaattta cgatttgatt cccactgcat taatataccg ttaattaagg ctttaatttc
     3421 tattttttca ccttctttat ccctaaagag agtttttact tcctggcaag gttcaaacat
     3481 tcctggccat ttatcagaat taataataat ttcatataca tcttctatct gagcattaca
     3541 aataattgaa tgtgattcta cataattcat tattgattcc tcaatgtaaa tagtttttta
     3601 ggatcgattg acttaattaa ctctgctttc aatatcttat cattatggct ttttggaaag
     3661 tattcatcag taacatagaa ccaatccggc catttttctc tactgagttt acgacttaaa
     3721 aatgatgaaa taatatcttc aatttcaggt aatgatttct tcgatatctc gccactcatg
     3781 caggcaaccg gttgatcaat agcaacacca ttttcatgga aagaaaaacc aacaaccgta
     3841 gccacattca cattgggtat tcgggataaa atagattcaa cttcttcagg ataaattcta
     3901 tgtccgttag cactcataaa agtattttgc ttacgtcctt ttaagactaa ataaccctct
     3961 tcatctatat aaccgagatc accagtggca aaccactcat caggaggtgt tatttctcca
     4021 gaaaggacat cataatatcc ttccataata ctttcacccc ttattataat ttctccaata
     4081 ttatcagatg agcctataat aggtttaacc gctaccgcca atgtattatc aattttgcca
     4141 acacaataaa ttgaattgag atatctttta tcacgatgat cttgctcatc tacccaacaa
     4201 aaaggaccat aagtttcact taacccatat ccctgcatcc attcacagcc aattaattga
     4261 cgccctttct ccagtacgct aggcggcatc gctgcggcac cataagcaac aacttgtaag
     4321 tcagagagat cgatattatg ttctgcggtt gatttaacga ataacttcat cgactctggg
     4381 cgtaacataa tatgagtgat tttattacga gaaagataat caggccatct ctctacattt
     4441 ctgtcttccg gtataaaaag tgttgattga tgtaataatg aaccgaaaga aaaaatcact
     4501 cccgttgtat tattcaacaa acctgacata aatattttag catcttgagt gaattttaat
     4561 ttctctgtca ccgaataaat tcgtcgacaa actaatgatt ctgaaatact aatggctttc
     4621 ggtttacctg tactaccact ggtgaacagg acaataaagt tagcaataga ttgcggagaa
     4681 taagttatta ttgggatttc cgcgatatca tcactgaccc ggatcttatg atctgaaata
     4741 tcaatcacat taatgttgtt ttcttttaat cttccaacaa aatgtttatc tttcttaagg
     4801 taaaccacaa aatcgtattg cacttcattg gtaaaattaa tccattcatc gattgtcgct
     4861 gatgataaat tatagggcat taataaatgc aaccccatag cactagccgc agctaaaaag
     4921 aaaataccta attcatcatg ttcaaatatg acaatgactt tactaccttt ttgaacacct
     4981 cgactaagta aatcatcaat taaatgggaa acagaagata ttacctcttt tcttgtatag
     5041 tgataatcct tagtgataat acaatcatga tgtaagttat cacgccctga atgtaacaac
     5101 atagagatta gtttcatttc tgtttccctt taattagcag ttaattttta tcgtttaaac
     5161 ttgatgagac gaaatcaagg actgctcttc ctgtttccca atgactgaat tgacttttcg
     5221 tcacggaaat accgaactct ttctcaatct cttttgccaa gtcagctaat tccgtagaat
     5281 ccatatcata ggcatcagca aggtttgcat ccatattgaa atcatcaata ttaatgttaa
     5341 gaaaaagaga caaaatcgtt tttattttta cttctggatg attattcata tatttttcct
     5401 cgcgtactta catattttag agattaaata gctgaaaaac tcaacgcaca cacatgacct
     5461 tgattactaa agcgctgaat gattatttgg ttagtatttg aaaactcatt gattttttta
     5521 gattgttgtt cctcatcccc atgactttct gacaagaatg atgacgccag gactgaatca
     5581 atcacgccac tgactgaaaa ttgattatcc aaatagggcc tcagatttat aaatgatgtt
     5641 tttatctctt tatttgagaa agccttactc gttatttctt tttcatcatc atatattcca
     5701 tccataataa atacagcatt ttcattatgg ttgaacagtt cagcggtata ttctaaggtg
     5761 ttatttctag tatttttatc cggtgcaaaa taatcaacaa agccggttaa ttcacacaat
     5821 atcgaagcac cacgttctaa agcatgttgt ctctcttcca gcaccagaaa tgccgcgcct
     5881 tcggaaaagt ctcctggctg tttttcgcca aaaacctcag agtgtttctg gcttgacgtt
     5941 ttctccagta aatttttaac taatgggctg gaaagatgtt ctgacgcacc acataacatc
     6001 acttccgcaa caccattaga aattgcttcc gccgcatagc ctattgcttg catccctgcc
     6061 acatcggagg tggaaaacgt tttagattgc gcactaaaac cataaagcag tgacaattgc
     6121 ccttgaagtg ccgcagggaa ccatgccgtg gcaacataag gccccattcc ctttatgcct
     6181 tcaatatgga gcgctttaac ttcatcctca atatgttgcc atccaccaaa acagtttccg
     6241 acatatatgc caacgcgatt aggatcaagc ttatcgacat ccaatctact cgcttttaat
     6301 gccatttcaa cggcaacgat accataaacc gaaaattcat caattttacg tcttaagcgg
     6361 ttattgatat atttcgcgcc atcgaaatca ctcaatgtcc ttattataga acttgcggtg
     6421 gtattgtttt tcgattcttg tcccaataac ttctgaatga cttttgattt tatggcagtg
     6481 acatcattgc catcaggatg tattgcacca acaccggtaa cgacaactct tttacgcatt
     6541 gtctactgcc ctcataacaa taacactgtg aataccagaa aaaccacttg ataattttaa
     6601 cgcggtctta attggatatg agcaaccttg attaggaata taatctaaat cgcaatcagg
     6661 atccggcgtt tgataattaa ttgttgggtg aacatactgc ttttctattt caagacataa
     6721 tgctacagac tcgatcgcat tagcggcggc taaagcatga cctgtcattg actttaatga
     6781 gttaattgga ataccaaatg cactttcacc caaaacaaat ttaatcgcat ttgattcgtt
     6841 aatatcattt tgcgctgtag aactgccatg agcactaata taatttaccg ttgatggcga
     6901 tatctgggca tccttcaatg ccatatcaat gcatcgtgcc attgccatgc catccgcggg
     6961 caagtcagtc atatgataag cattattgac ggatgcgtac cctgctaatt cagcatagat
     7021 atgtgctcca cgctgcttag cgtgttcata agactctaaa attaatattc cacacccttc
     7081 tgcaatcaca aatccatccc gctcaaggga aaaaggacaa gttgctgctt gctgattttc
     7141 caactctctt gatgatagcg cccctaaagc ttcaaaagag ccgatagaga gtggacaaag
     7201 tggcgcttca cttgcaccag ccagcataat atccgctctg ccataacgga tatgctccat
     7261 cgcaatgcct aatgcatcaa gccctgccgc acatccggtt gatatgttac tgacggacat
     7321 agatgcacca tattttttcg caacagaggt tgcggcagag ctgaaatcaa agctgtcgta
     7381 atcttctgat ttaattaaat cagggtgaat attctctttg ccccctttgg tgattctgag
     7441 taaacactct tccattcccg cagcatcggc aatcgctgtc gctatcgcaa caccaaaacg
     7501 tcgaccatca atgtctgagg gtcttaaatt tgcatcttgc atcgccatct cagcggcatc
     7561 tagcgcaaac tggagatatt tacgctcact tttcagaaca aactctttgt tattgccatc
     7621 actaccgtaa acttgtccta ttgctccgct tttaaagcca aatctttctc ttccccactc
     7681 atatttactc actcccgatt tcccgttatg aatattgttc caaaattcat taacgccaac
     7741 acctgtcggt gcaacaacac ctagccctgt caccacaact ctacgtggtt gagattcatt
     7801 tctgttattt attatcacaa taattatctc gatagaaata gaataaacat ttactcaggc
     7861 aaattttatt aatataaaac ttacccattt tcatttaaga aaatcgttat ctgcaagtag
     7921 tgatattaaa ctactttatc tataaaatta tatttgtcat atatatttga tttttatctc
     7981 ctaaccaaat ttcttgaaaa taagcaccaa accataattc cactttaata tccatttggt
     8041 tatttcactg atttttcatc tatttaaact gcaagaataa tatgaatgtt tcaggttaaa
     8101 ccaaactaag ttaactccct tcgatctaca tatggataga gtaactaagc gttttcttaa
     8161 tgactcaatt tactcttaaa aatcatccag aaaggagatg acaaatttat tattatagaa
     8221 ctgatatatt cactcacagt acaatatagc caaacaacat agcaaagata atatatcttt
     8281 ttctagctta tacccgttat ccttcaagtt gcctctttgt tagctgcact cgctcacccc
     8341 ggtcacatcg ttatctatgc tcccggggat tcactccctt gccgtcgcga tccatcttga
     8401 aatccattgg gtatatgaaa tctcttttct gctcatattc tccccgtctg accctataat
     8461 gacatattat tataatattg cgaccactcg actccatgaa gcatctgctt tctctaattt
     8521 tattggaaaa cagcacactt taaatccata aggtttagga atactggtta aattacaaag
     8581 ccgttctatc tgtaaataag ggtgatcccg cccgataaaa tgagatggcc ataagcaatc
     8641 tttattcccc gtttttttat aatcgttaat catctctatg aatggccgat caaagctaaa
     8701 tgcatctgtc ccaataatct ttaccccttg ctctactaac cattgaacag cactgctttc
     8761 aatcgcttta tagtgagtaa aataggattt ttcccccagg agtttatccg ctccagtatt
     8821 gatcaggaca atatcatttt cttttatttt ataattaatt ttctttaatt ggttttctac
     8881 cgcctgttta tcaattgatt gattatcatg actaaaatca agtaatacac cgtggctata
     8941 aaaccaatcc aaaggaatat cagtaattgt tgctggctga tcttgccctt tatgccaccc
     9001 atagtgatag ggagcatcaa tatgcgttcc agtatgcgtg gtcaatcgat aatacatcag
     9061 tgataatccc ataccatcag gaaaatcatt gtgatcaatg atccactttt tgcgtttaaa
     9121 cagttttaca aaggctcttt tccaccatga attggtatgg aaatataaat aactttcacc
     9181 taatttatta gcgccctctt tatgatcaac gactcctcta gttactttct caggttccca
     9241 aaaatcacaa tctataggaa cacttaagtc aataatatta ctcatctttg ttccttataa
     9301 tctcgaaata gtttatttcc ttgatatttg gtgtagaaat taccttcttt tgagataatg
     9361 cacaaacaaa ttgctgatga tgaatcaata atgtgctcgc ctctaattct ttcatatctt
     9421 taacagaatc agagttatta gccaataatt tctcatgtaa agtcgaagca aataatttaa
     9481 tatatgcttc aagtctaacc caacagtata atgacattaa gtgataatag tttttaaatc
     9541 cgggactcac tcctgatagt tgttttaaca ttataccttt tatatattcc aactccttat
     9601 ccttaataaa acgttcaata atttcagaaa attttatctt agaaggagtg acttcaatat
     9661 caacacctat ttctcttgag ctaaacccga tggcgcaata gtttcctgat gcactcagag
     9721 aaaaataata tttgaagtct tgctccgtgg atatataagg tttaccgtta tcattcgtta
     9781 tgatttcata atcagataaa tattgattta aaacataacg taacgcagcc cgtctaaata
     9841 taaatttttt tcttctatcc gctaaacaaa tttggttatg gcgaacgata tcagaccggt
     9901 gaattaactg ttcaatagaa gataaatcaa tatcgtcgat ttttataatc caaagatcag
     9961 aaaaatcaga tgataaagaa atatcgtcca tgat
//
