BGC0000197: aranciamycin biosynthetic gene cluster from Streptomyces echinatus
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Location: 1 - 35,936 nt. (total: 35,936 nt).
This entry is originally from NCBI GenBank DQ915964.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000197
Short description aranciamycin biosynthetic gene cluster from Streptomyces echinatus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Anthracycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: DQ915964.1
Compounds
  • aranciamycin
Species Streptomyces echinatus [taxonomy]
References
Chemical products information
aranciamycin
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C27H28O12
Chemical database entries
NPAtlas
PubCHEM
ChEMBL
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABL09949.1
 711 - 1541 (-) SCC75A.25c
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  • ABL09950.1
 2069 - 2680 (-) hypothetical protein
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  • ABL09951.1
 3617 - 5569 (+) oxidoreductase
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  • ABL09952.1
 6024 - 8852 (-) response regulator
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  • ABL09953.1
 9913 - 11256 (-) oxidoreductase
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  • ABL09954.1
 11272 - 12216 (-) cyclase
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  • ABL09955.1
 12254 - 13039 (-) ketoreductase
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  • ABL09956.1
 13224 - 13679 (+) aromatase
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  • ABL09957.1
 13854 - 14120 (-) acyl carrier protein
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  • ABL09958.1
 14144 - 15370 (-) chain length factor
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  • ABL09959.1
 15367 - 16638 (-) ketoacyl synthase
  • Scaffold biosynthesis
Knock-out
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  • ABL09960.1
 16844 - 17617 (-) cyclase
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  • ABL09961.1
 18199 - 18807 (+) regulator
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  • ABL09962.1
 18737 - 19957 (-) signal transduction histidine kinase
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  • ABL09963.1
 20708 - 21517 (+) pathway specific transcription activator
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  • ABL09964.1
 21990 - 22646 (-) unknown
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  • ABL09965.1
 22835 - 25870 (-) helicase
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  • ABL09966.1
 26090 - 27349 (-) O-methyltransferase
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  • ABL09967.1
 27737 - 29260 (+) transmembrane efflux protein
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  • ABL09968.1
 29585 - 30868 (+) L-rhamnosyltransferase
  • Tailoring (Glycosylation)
Activity assay
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  • ABL09969.1
 31341 - 32867 (-) oxidoreductase
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  • ABL09970.1
 33305 - 34192 (+) oxidoreductase
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  • ABL09971.1
 34703 - 35758 (+) methyltransferase
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Polyketide-specific information
Subclass Anthracycline
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
ABL09959.1
+
ABL09954.1
+
ABL09960.1 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Glycosyltransferases
ABL09968.1
Specificity: Multiple (promiscuous)
Evidence:
  • Knock-out construct
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: LPHAMZXQ3BT6INJWOLKUYGWU, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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