BGC0000197 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000197 (Streptomyces echinatus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	35,936	High	aranciamycin	PKS:Type II+saccharide:hybrid/tailoring

BGC0000197 - Region 1 - T2PKS

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Location: 1 - 35,936 nt. (total: 35,936 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,937
Label		BGC0000197

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

ABL09953.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

ABL09955.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ABL09969.1: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

ABL09970.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase

ABL09968.1: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase

ABL09954.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

ABL09958.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ABL09959.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000197.5	1.00	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000231.5	0.78	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.69	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0002514.3	0.57	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000197.5	1.00	PKS, saccharide	aranciamycin	Streptomyces echinatus
BGC0000231.5	0.78	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.69	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0002514.3	0.57	PKS	julichrome Q6.6	Streptomyces sampsonii
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 35936
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 677.2; E-value: 1.6e-206)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: acetyl-CoA_8: 529 Da
acetyl-CoA_9: 571 Da

ABL09954.1: CYC C7-C12 (Score: 458.7; E-value: 1.8e-140)
ABL09955.1: KR C9 (Score: 472.1; E-value: 9.7e-145)
ABL09956.1: CYC C1-C18|C2-C19 (Score: 223.7; E-value: 1.7e-69)
ABL09957.1: ACP (Score: 120.3; E-value: 6.1e-38)
ABL09958.1: CLF 8|9 (Score: 677.2; E-value: 1.6e-206)
ABL09959.1: KS (Score: 785.1; E-value: 3.2e-239)
ABL09960.1: CYC C5-C14/C3-C16 (Score: 446.7; E-value: 5.5e-137)
ABL09966.1: MET C18O (Score: 731.6; E-value: 4.8e-223)
ABL09968.1: GT (Score: 452.2; E-value: 4.8e-138)
ABL09970.1: KR C17 (Score: 407.5; E-value: 4.7e-125)
ABL09971.1: MET C18O (Score: 454.5; E-value: 7e-139)