Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000198.1:
Cluster 1Polyketide / Saccharide138025

BGC0000198, arenimycin B biosynthetic gene cluster from Salinispora arenicola. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Arenimycin A
SMILES string: Copy to clipboard
Molecular formula: C33H33NO14
Exact molecular mass: 667.1901 Da ([M+H]+)
Molecular activity: Antibacterial, Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Benzoisochromanequinone (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
WP_029025958.1,WP_029025959.1
Genes involved in folding/cyclization:
WP_029025952.1, WP_029025951.1

Saccharide subclass:
hybrid/tailoring
Glycosyltransferases:
UNKNOWN:
Specificity: 2-O-methyl-L-rhamnose
Evidence for specificity: Structure-based inference
UNKNOWN:
Specificity: L-forosamine
Evidence for specificity: Structure-based inference

Gene cluster description

arenimycin B (BGC0000198). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank NZ_AZXI01000002, positions 3084-41108. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Bradley S Moore (Scripps Institution of Oceanography)

Literature references

1. Kersten RD et al. (2013) Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc Natl Acad Sci U S A 110(47):E4407-16. doi:
2. Asolkar RN et al. (2010) Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (Tokyo) 63(1):37-9. doi: 10.1038/ja.2009.114. Epub 2009 Nov