BGC0000198: arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 3,084 - 41,108 nt. (total: 38,025 nt).
This entry is originally from NCBI GenBank NZ_AZXI01000002.1, but has been modified (see Modifications tab for details).

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000198
Short description arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
NZ_AZXI01000002.1
3084 - 41108
via
Compounds
  • arenimycin A
Species Salinispora arenicola CNB527 [taxonomy]
References
Chemical products information
arenimycin A Evidence:
Copy SMILES
C33H33N1O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • B033_RS0101505
  • WP_029025939.1
  • rfbA
3084 - 3965 (+) glucose-1-phosphate thymidylyltransferase
  • Precursor biosynthesis
copy AA seq
copy Nt seq
  • B033_RS27985
  • WP_051422523.1
3985 - 4641 (+) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
    copy AA seq
    copy Nt seq
    • B033_RS0101515
    • WP_196237056.1
    4613 - 5113 (-) MarR family winged helix-turn-helix transcriptional regulator
      copy AA seq
      copy Nt seq
      • B033_RS0101520
      • WP_029025941.1
      5248 - 6198 (+) ABC transporter
      • Transport
      copy AA seq
      copy Nt seq
      • B033_RS0101525
      • WP_029025942.1
      6213 - 7037 (+) ABC transporter permease
      • Transport
      copy AA seq
      copy Nt seq
      • B033_RS0101530
      • WP_051422525.1
      7180 - 7923 (-) class I SAM-dependent methyltransferase
        copy AA seq
        copy Nt seq
        • B033_RS0101535
        • WP_029025944.1
        7920 - 9080 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
          copy AA seq
          copy Nt seq
          • B033_RS27990
          • WP_051422526.1
          • rfbH
          9077 - 10429 (-) lipopolysaccharide biosynthesis protein RfbH
            copy AA seq
            copy Nt seq
            • B033_RS0101545
            • WP_155254773.1
            10426 - 11625 (-) hypothetical protein
              copy AA seq
              copy Nt seq
              • B033_RS27995
              • WP_042941991.1
              11703 - 12833 (-) hypothetical protein
                copy AA seq
                copy Nt seq
                • B033_RS0101555
                • WP_029025946.1
                13104 - 14339 (+) activator-dependent family glycosyltransferase
                  copy AA seq
                  copy Nt seq
                  • B033_RS28000
                  • WP_051422528.1
                  14351 - 15823 (+) M20/M25/M40 family metallo-hydrolase
                    copy AA seq
                    copy Nt seq
                    • B033_RS0101565
                    • WP_029025947.1
                    15744 - 16088 (-) DUF6176 family protein
                      copy AA seq
                      copy Nt seq
                      • B033_RS28005
                      • WP_051422530.1
                      16173 - 17408 (-) cytochrome P450
                        copy AA seq
                        copy Nt seq
                        • B033_RS0101575
                        • WP_042941996.1
                        17570 - 18301 (+) PIG-L deacetylase family protein
                          copy AA seq
                          copy Nt seq
                          • B033_RS28010
                          • WP_051422532.1
                          18309 - 19460 (-) DUF1205 domain-containing protein
                            copy AA seq
                            copy Nt seq
                            • B033_RS0101585
                            • WP_029025949.1
                            19488 - 20465 (-) aldo/keto reductase
                              copy AA seq
                              copy Nt seq
                              • B033_RS32390
                              • WP_196237057.1
                              20731 - 21771 (+) methyltransferase
                                copy AA seq
                                copy Nt seq
                                • B033_RS28015
                                • WP_051422534.1
                                21810 - 23432 (+) FAD-dependent monooxygenase
                                  copy AA seq
                                  copy Nt seq
                                  • B033_RS28020
                                  • WP_042941974.1
                                  23509 - 24339 (-) AfsR/SARP family transcriptional regulator
                                    copy AA seq
                                    copy Nt seq
                                    • B033_RS28025
                                    • WP_042941976.1
                                    24566 - 24919 (+) TcmI family type II polyketide cyclase
                                      copy AA seq
                                      copy Nt seq
                                      • B033_RS0101610
                                      • WP_029025951.1
                                      24916 - 25320 (+) hypothetical protein
                                      • Scaffold biosynthesis
                                      copy AA seq
                                      copy Nt seq
                                      • B033_RS0101615
                                      • WP_029025952.1
                                      25320 - 25805 (+) polyketide cyclase
                                      • Scaffold biosynthesis
                                      copy AA seq
                                      copy Nt seq
                                      • B033_RS28030
                                      • WP_155254779.1
                                      25877 - 26164 (+) antibiotic biosynthesis monooxygenase family protein
                                        copy AA seq
                                        copy Nt seq
                                        • B033_RS32395
                                        26213 - 26499 (-) hypothetical protein
                                          copy AA seq
                                          copy Nt seq
                                          • B033_RS0101630
                                          26394 - 26765 (-) hypothetical protein
                                            Derived by automated computational analysis using gene prediction method: GeneMarkS+.
                                            copy AA seq
                                            copy Nt seq
                                            • B033_RS32400
                                            26541 - 26914 (-) acetyl-CoA carboxylase carboxyl transferase subunit beta
                                              copy AA seq
                                              copy Nt seq
                                              • B033_RS33100
                                              26930 - 27148 (-) hypothetical protein
                                                copy AA seq
                                                copy Nt seq
                                                • B033_RS28035
                                                • WP_080678870.1
                                                27456 - 28559 (+) AfsR/SARP family transcriptional regulator
                                                  copy AA seq
                                                  copy Nt seq
                                                  • B033_RS0101640
                                                  • WP_029025954.1
                                                  28590 - 29432 (+) class I SAM-dependent methyltransferase
                                                    copy AA seq
                                                    copy Nt seq
                                                    • B033_RS0101645
                                                    • WP_196237058.1
                                                    29584 - 30003 (-) nuclear transport factor 2 family protein
                                                      copy AA seq
                                                      copy Nt seq
                                                      • B033_RS0101650
                                                      • WP_029025956.1
                                                      30056 - 30511 (-) DUF1772 domain-containing protein
                                                        copy AA seq
                                                        copy Nt seq
                                                        • B033_RS0101655
                                                        • WP_051422536.1
                                                        30734 - 31972 (+) cytochrome P450
                                                          copy AA seq
                                                          copy Nt seq
                                                          • B033_RS0101660
                                                          • WP_029025958.1
                                                          32270 - 33538 (+) beta-ACP synthase
                                                          • Scaffold biosynthesis
                                                          copy AA seq
                                                          copy Nt seq
                                                          • B033_RS0101665
                                                          • WP_029025959.1
                                                          33535 - 34752 (+) beta-ketoacyl synthase
                                                          • Scaffold biosynthesis
                                                          copy AA seq
                                                          copy Nt seq
                                                          • B033_RS0101670
                                                          • WP_029025960.1
                                                          34845 - 35570 (+) SDR family NAD(P)-dependent oxidoreductase
                                                            copy AA seq
                                                            copy Nt seq
                                                            • B033_RS28040
                                                            • WP_080678872.1
                                                            35639 - 37015 (+) NDP-hexose 2,3-dehydratase family protein
                                                              copy AA seq
                                                              copy Nt seq
                                                              • B033_RS28045
                                                              • WP_051422538.1
                                                              37012 - 38010 (+) Gfo/Idh/MocA family oxidoreductase
                                                                copy AA seq
                                                                copy Nt seq
                                                                • B033_RS0101685
                                                                • WP_029025961.1
                                                                38089 - 38343 (+) acyl carrier protein
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • B033_RS0101690
                                                                  • WP_042941978.1
                                                                  38340 - 38666 (+) antibiotic biosynthesis monooxygenase family protein
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • B033_RS28050
                                                                    • WP_051422540.1
                                                                    • rfbB
                                                                    39238 - 40257 (+) dTDP-glucose 4,6-dehydratase
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • B033_RS0101700
                                                                      • WP_196237059.1
                                                                      • rfbD
                                                                      40257 - 41108 (+) dTDP-4-dehydrorhamnose reductase
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        Biosynthesis information
                                                                        Annotation changelog

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        Removed gene names of 'No gene ID'
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Removed glycosyltransferase annotations on missing genes
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        Submitted
                                                                        • (ID: N52IJH5LHPQ7BFWMKQOBW6U7)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Detailed domain annotation
                                                                        Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
                                                                        A domain glossary is available here, and an explanation of the visualisation is available here.
                                                                        Selected features only
                                                                        Show module domains
                                                                        Similar known gene clusters from MIBiG 4.0
                                                                        Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                        Click on reference genes to show details of similarities to genes within the current region.
                                                                        Click on an accession to open that entry in the MiBIG database.
                                                                        Modifications to original record
                                                                        • B033_RS0101630 was added