BGC0000198: arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
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Location: 3,084 - 41,108 nt. (total: 38,025 nt).
This entry is originally from NCBI GenBank NZ_AZXI01000002.1, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
Modifications
General information about the BGC
MIBiG accession BGC0000198
Short description arenimycin A biosynthetic gene cluster from Salinispora arenicola CNB527
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
NZ_AZXI01000002.1
3084 - 41108
via
Compounds
  • arenimycin A
Species Salinispora arenicola CNB527 [taxonomy]
References
Chemical products information
arenimycin A Evidence:
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C33H33N1O14
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Comment Extra
  • B033_RS0101505
  • WP_029025939.1
  • rfbA
 3084 - 3965 (+) glucose-1-phosphate thymidylyltransferase
  • Precursor biosynthesis
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  • B033_RS27985
  • WP_051422523.1
 3985 - 4641 (+) dTDP-4-dehydrorhamnose 3,5-epimerase family protein
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    • B033_RS0101515
    • WP_196237056.1
    		 4613 - 5113 (-) MarR family winged helix-turn-helix transcriptional regulator
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      • B033_RS0101520
      • WP_029025941.1
      		 5248 - 6198 (+) ABC transporter
      • Transport
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      • B033_RS0101525
      • WP_029025942.1
      		 6213 - 7037 (+) ABC transporter permease
      • Transport
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      • B033_RS0101530
      • WP_051422525.1
      		 7180 - 7923 (-) class I SAM-dependent methyltransferase
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        • B033_RS0101535
        • WP_029025944.1
        		 7920 - 9080 (-) DegT/DnrJ/EryC1/StrS family aminotransferase
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          • B033_RS27990
          • WP_051422526.1
          • rfbH
          		 9077 - 10429 (-) lipopolysaccharide biosynthesis protein RfbH
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            • B033_RS0101545
            • WP_155254773.1
            		 10426 - 11625 (-) hypothetical protein
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              • B033_RS27995
              • WP_042941991.1
              		 11703 - 12833 (-) hypothetical protein
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                • B033_RS0101555
                • WP_029025946.1
                		 13104 - 14339 (+) activator-dependent family glycosyltransferase
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                  • B033_RS28000
                  • WP_051422528.1
                  		 14351 - 15823 (+) M20/M25/M40 family metallo-hydrolase
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                    • B033_RS0101565
                    • WP_029025947.1
                    		 15744 - 16088 (-) DUF6176 family protein
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                      • B033_RS28005
                      • WP_051422530.1
                      		 16173 - 17408 (-) cytochrome P450
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                        • B033_RS0101575
                        • WP_042941996.1
                        		 17570 - 18301 (+) PIG-L deacetylase family protein
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                          • B033_RS28010
                          • WP_051422532.1
                          		 18309 - 19460 (-) DUF1205 domain-containing protein
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                            • B033_RS0101585
                            • WP_029025949.1
                            		 19488 - 20465 (-) aldo/keto reductase
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                              • B033_RS32390
                              • WP_196237057.1
                              		 20731 - 21771 (+) methyltransferase
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                                • B033_RS28015
                                • WP_051422534.1
                                		 21810 - 23432 (+) FAD-dependent monooxygenase
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                                  • B033_RS28020
                                  • WP_042941974.1
                                  		 23509 - 24339 (-) AfsR/SARP family transcriptional regulator
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                                    • B033_RS28025
                                    • WP_042941976.1
                                    		 24566 - 24919 (+) TcmI family type II polyketide cyclase
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                                      • B033_RS0101610
                                      • WP_029025951.1
                                      		 24916 - 25320 (+) hypothetical protein
                                      • Scaffold biosynthesis
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                                      • B033_RS0101615
                                      • WP_029025952.1
                                      		 25320 - 25805 (+) polyketide cyclase
                                      • Scaffold biosynthesis
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                                      • B033_RS28030
                                      • WP_155254779.1
                                      		 25877 - 26164 (+) antibiotic biosynthesis monooxygenase family protein
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                                        • B033_RS32395
                                        		 26213 - 26499 (-) hypothetical protein
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                                          • B033_RS0101630
                                          		 26394 - 26765 (-) hypothetical protein
                                            Derived by automated computational analysis using gene prediction method: GeneMarkS+.
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                                            • B033_RS32400
                                            		 26541 - 26914 (-) acetyl-CoA carboxylase carboxyl transferase subunit beta
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                                              • B033_RS33100
                                              		 26930 - 27148 (-) hypothetical protein
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                                                • B033_RS28035
                                                • WP_080678870.1
                                                		 27456 - 28559 (+) AfsR/SARP family transcriptional regulator
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                                                  • B033_RS0101640
                                                  • WP_029025954.1
                                                  		 28590 - 29432 (+) class I SAM-dependent methyltransferase
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                                                    • B033_RS0101645
                                                    • WP_196237058.1
                                                    		 29584 - 30003 (-) nuclear transport factor 2 family protein
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                                                      • B033_RS0101650
                                                      • WP_029025956.1
                                                      		 30056 - 30511 (-) DUF1772 domain-containing protein
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                                                        • B033_RS0101655
                                                        • WP_051422536.1
                                                        		 30734 - 31972 (+) cytochrome P450
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                                                          • B033_RS0101660
                                                          • WP_029025958.1
                                                          		 32270 - 33538 (+) beta-ACP synthase
                                                          • Scaffold biosynthesis
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                                                          • B033_RS0101665
                                                          • WP_029025959.1
                                                          		 33535 - 34752 (+) beta-ketoacyl synthase
                                                          • Scaffold biosynthesis
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                                                          • B033_RS0101670
                                                          • WP_029025960.1
                                                          		 34845 - 35570 (+) SDR family NAD(P)-dependent oxidoreductase
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                                                            • B033_RS28040
                                                            • WP_080678872.1
                                                            		 35639 - 37015 (+) NDP-hexose 2,3-dehydratase family protein
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                                                              • B033_RS28045
                                                              • WP_051422538.1
                                                              		 37012 - 38010 (+) Gfo/Idh/MocA family oxidoreductase
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                                                                • B033_RS0101685
                                                                • WP_029025961.1
                                                                		 38089 - 38343 (+) acyl carrier protein
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                                                                  • B033_RS0101690
                                                                  • WP_042941978.1
                                                                  		 38340 - 38666 (+) antibiotic biosynthesis monooxygenase family protein
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                                                                    • B033_RS28050
                                                                    • WP_051422540.1
                                                                    • rfbB
                                                                    		 39238 - 40257 (+) dTDP-glucose 4,6-dehydratase
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                                                                      • B033_RS0101700
                                                                      • WP_196237059.1
                                                                      • rfbD
                                                                      		 40257 - 41108 (+) dTDP-4-dehydrorhamnose reductase
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                                                                        Biosynthesis information
                                                                        Annotation changelog

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-10-07
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-09-15
                                                                        Removed gene names of 'No gene ID'
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2022-09-15
                                                                        Removed glycosyltransferase annotations on missing genes
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2019-10-16
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2015-06-12
                                                                        Submitted
                                                                        • (ID: N52IJH5LHPQ7BFWMKQOBW6U7)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Detailed domain annotation
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                                                                        Modifications to original record
                                                                        • B033_RS0101630 was added