BGC0000199: arimetamycin B biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 40,894 nt. (total: 40,894 nt).
This entry is originally from NCBI GenBank KF040454.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000199
Short description arimetamycin B biosynthetic gene cluster from uncultured bacterium
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
KF040454.1
via Heterologous expression
Compounds
  • arimetamycin B
  • arimetamycin C
  • arimetamycin A
Species uncultured bacterium [taxonomy]
References
Chemical products information
arimetamycin B Evidence:
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C27H28O12
Chemical database entries
NPAtlas
arimetamycin C Evidence:
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C28H30O12
arimetamycin A Evidence:
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C39H52N2O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHA81971.1
 1 - 781 (-) putative hydroxylase
  • Tailoring
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  • AHA82007.1
  • arm1
 884 - 1561 (-) O-methyl transferase
  • Tailoring
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  • AHA81972.1
  • arm2
 1554 - 2483 (-) Aromatase
  • Scaffold biosynthesis
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  • AHA81973.1
  • arm3
 2591 - 3370 (-) Cyclase
  • Scaffold biosynthesis
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  • AHA81974.1
  • arm4
 3553 - 3993 (+) Cyclase
  • Scaffold biosynthesis
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  • AHA81975.1
  • arm5
 4035 - 4802 (+) Ketoreductase
  • Scaffold biosynthesis
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  • AHA81976.1
  • arm6
 4869 - 5210 (+) Monooygenase
  • Tailoring
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  • AHA81977.1
  • arm7
 5243 - 6511 (+) KSα
  • Scaffold biosynthesis
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  • AHA81978.1
  • arm8
 6508 - 7731 (+) KSβ (CLF)
  • Scaffold biosynthesis
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  • AHA81979.1
  • arm9
 7747 - 8004 (+) ACP
  • Scaffold biosynthesis
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  • AHA81980.1
  • arm10
 8457 - 9212 (+) SARP family transcriptional regulator
  • Regulation
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  • AHA81981.1
  • arm11
 9461 - 10612 (+) P450-oxidoreductase
  • Tailoring
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  • AHA81982.1
  • arm12
 10674 - 11924 (+) Glycosyltransferase
  • Scaffold biosynthesis
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  • AHA81983.1
  • arm13
 11953 - 12282 (+) Unknown
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    • AHA81984.1
    • arm14
    		 12279 - 13454 (+) O-methyltransferase
    • Tailoring
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    • AHA81985.1
    • arm15
    		 13473 - 14639 (+) Oxygenase
    • Tailoring
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    • AHA81986.1
    • arm16
    		 14716 - 16263 (-) Dehydrogenase
    • Tailoring
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    • AHA81987.1
    • arm17
    		 16260 - 17456 (-) P450-oxidoreductase
    • Tailoring
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    • AHA81988.1
    • arm19
    		 18104 - 20044 (+) MarR family transcriptional regulator
    • Regulation
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    • AHA81989.1
    • arm20
    		 20041 - 20604 (+) Unknown
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      • AHA81990.1
      • arm21
      		 20618 - 23404 (-) Unknown
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        • AHA81991.1
        • arm22
        		 23624 - 24763 (+) NDP-hexose-C3-methyltransferase
        • Tailoring
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        • AHA81992.1
        • arm23
        		 24783 - 25757 (-) NDP-4-keto-6-deoxyhexose reductase
        • Tailoring
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        • AHA81993.1
        • arm24
        		 25948 - 27111 (+) NDP-hexose-3-aminotransferase
        • Tailoring
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        • AHA81994.1
        • arm25
        		 27147 - 28430 (+) Glycosyltransferase
        • Scaffold biosynthesis
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        • AHA81995.1
        • arm26
        		 28503 - 29354 (-) ABC transporter
        • Transport
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        • AHA81996.1
        • arm27
        		 29351 - 30412 (-) ANC transporter A TP-binding protein
        • Transport
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        • AHA81997.1
        • arm28
        		 30529 - 31518 (-) NDP-hexose-3-ketoreductase
        • Tailoring
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        • AHA81998.1
        • arm29
        		 31717 - 32871 (+) NDP-hexose-4-aminotransferase
        • Tailoring
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        • AHA81999.1
        • arm30
        		 32891 - 33655 (+) NDP-hexose-N,N-dimethyltransferase
        • Tailoring
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        • AHA82000.1
        • arm31
        		 33652 - 34878 (+) NDP-hexose-C3-methyltransferase
        • Tailoring
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        • AHA82001.1
        • arm32
        		 34868 - 36043 (+) P450-oxidoreductase
        • Tailoring
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        • AHA82002.1
        • arm33
        		 36073 - 37410 (+) Glycosyltransferase
        • Scaffold biosynthesis
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        • AHA82003.1
        • arm34
        		 37403 - 38113 (+) NDP-hexose-N,N-dimethyltransferase
        • Tailoring
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        • AHA82004.1
        • arm35
        		 38103 - 38723 (-) NDP-hexose-3,5-epimerase
        • Tailoring
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        • AHA82005.1
        • arm36
        		 38720 - 40273 (-) NDP-hexose-2,3-dehydratase
        • Tailoring
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        • AHA82006.1
        		 40441 - 40743 (+) transposase
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          Biosynthesis information
          Annotation changelog

          Entry version: 4

          Date
          Changes
          Submitters
          Reviewers
          2022-10-07
          Update chemical activity to schema version 2.11
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 3

          Date
          Changes
          Submitters
          Reviewers
          2022-09-15
          Removed gene names of 'No gene ID'
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Removed duplicate gene name
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2022-09-15
          Updated bioactivity data
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 2

          Date
          Changes
          Submitters
          Reviewers
          2019-10-16
          Migrated from v1.4
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          2019-10-16
          Updated compound(s) information (NPAtlas curation)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2015-06-12
          Submitted
          • (ID: V5OJFE3GCDVKSA62LSGPW5E6)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
          Detailed domain annotation
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