Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000199.1:
Cluster 1Polyketide / Saccharide140894

BGC0000199, arimetamycin biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Arimetamycin B
SMILES string: Copy to clipboard
Molecular formula: C27H28O12
Exact molecular mass: 544.1581 Da (None)
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Tetracycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AHA81977.1,AHA81978.1,AHA81979.1
Genes involved in folding/cyclization:
AHA81972.1, AHA81973.1, AHA81974.1, AHA81975.1

Gene cluster description

arimetamycin (BGC0000199). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KF040454, positions 1-40894. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sean Brady (The Rockefeller Univeristy)

Literature references

1. Kang HS, Brady SF. (2013) Arimetamycin A: improving clinically relevant families of natural products through sequence-guided screening of soil metagenomes. Angew Chem Int Ed Engl 52(42):11063-7. doi: 10.1002/anie.201305109.