BGC0000200: arixanthomycin A biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 31,965 nt. (total: 31,965 nt).
This entry is originally from NCBI GenBank KF931341.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000200
Short description arixanthomycin A biosynthetic gene cluster from uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KF931341.1
Compounds
  • arixanthomycin A
  • arixanthomycin B
  • arixanthomycin C
Species uncultured bacterium [taxonomy]
References
Chemical products information
arixanthomycin A
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C37H37N1O14
arixanthomycin B
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C29H23N1O9
arixanthomycin C
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C28H21N1O9
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • arx1
  • AHX24686.1
 1 - 1059 (-) NAD-dependent epimerase/dehydratase
  • Tailoring (Epimerization)
Sequence-based prediction
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  • arx2
  • AHX24687.1
 1062 - 1796 (-) hypothetical protein
  • Unknown
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  • arx3
  • AHX24688.1
 1822 - 2988 (-) glycosyltransferase
  • Tailoring (Glycosylation)
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  • arx4
  • AHX24689.1
 3207 - 3887 (+) short-chain dehydrogenase/reductase SDR
  • Precursor biosynthesis
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  • arx5
  • AHX24690.1
 3911 - 5761 (+) amidotransferase
  • Tailoring (Unknown)
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  • arx6
  • AHX24691.1
 5791 - 6855 (+) O-methyltransferase
  • Tailoring (Methylation)
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  • arx7
  • AHX24692.1
 6917 - 7744 (-) ABC transporter
  • Transport
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  • arx8
  • AHX24693.1
 7741 - 8697 (-) ABC transporter ATP-binding protein
  • Transport
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  • arx9
  • AHX24694.1
 8694 - 9872 (-) glycosyltransferase
  • Tailoring (Glycosylation)
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  • arx10
  • AHX24695.1
 9874 - 11460 (-) FAD-binding monooxygenase
  • Tailoring (Monooxygenation)
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  • arx11
  • AHX24696.1
 12253 - 13065 (-) hypothetical protein
  • Unknown
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  • arx12
  • AHX24697.1
 13091 - 14125 (-) O-methyltransferase
  • Tailoring (Methylation)
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  • arx13
  • AHX24698.1
 14331 - 15218 (+) dehydrogenase
  • Tailoring (Dehydration)
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  • arx14
  • AHX24699.1
 15240 - 15575 (+) cyclase
  • Scaffold biosynthesis
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  • arx15
  • AHX24700.1
 15572 - 16003 (+) cyclase
  • Scaffold biosynthesis
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  • arx16
  • AHX24701.1
 16000 - 17268 (+) beta-ketoacyl synthase alpha
  • Scaffold biosynthesis
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  • arx17
  • AHX24702.1
 17272 - 18510 (+) beta-ketoacyl synthase beta
  • Scaffold biosynthesis
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  • arx18
  • AHX24703.1
 18510 - 18773 (+) acyl carrier protein
  • Scaffold biosynthesis
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  • arx19
  • AHX24704.1
 18775 - 19236 (+) cyclase
  • Scaffold biosynthesis
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  • arx20
  • AHX24705.1
 19243 - 19701 (+) monooxygenase
  • Tailoring (Monooxygenation)
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  • arx21
  • AHX24706.1
 19725 - 20483 (+) 3-oxoacyl-ACP reductase
  • Tailoring (Reduction)
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  • arx22
  • AHX24707.1
 20483 - 20836 (+) monooxygenase
  • Tailoring (Monooxygenation)
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  • arx23
  • AHX24708.1
 20833 - 21144 (+) monooxygenase
  • Tailoring (Monooxygenation)
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  • arx24
  • AHX24709.1
 21158 - 21961 (+) NDP-4-ketoreductase
  • Tailoring (Reduction)
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  • arx25
  • AHX24710.1
 22020 - 22475 (-) hypothetical protein
  • Unknown
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  • arx26
  • AHX24711.1
 22478 - 22858 (-) hypothetical protein
  • Unknown
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  • arx27
  • AHX24712.1
 22858 - 23595 (-) 3-oxoacyl-ACP reductase
  • Tailoring (Reduction)
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  • arx28
  • AHX24713.1
 23592 - 25082 (-) putative peptide transporter
  • Transport
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  • arx29
  • AHX24714.1
 25098 - 25478 (-) CurD-like protein
  • Unknown
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  • arx30
  • AHX24715.1
 25490 - 27076 (-) FAD-binding monooxygenase
  • Tailoring (Monooxygenation)
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  • arx31
  • AHX24716.1
 27260 - 27943 (-) LuxR family transcriptional regulator
  • Regulation
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  • arx32
  • AHX24717.1
 27940 - 29121 (-) two-component system histidine kinase
  • Regulation
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  • arx33
  • AHX24718.1
 29300 - 30136 (+) F420-dependent reductase
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  • arx34
  • AHX24719.1
 30183 - 31214 (+) putative methyltransferase
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  • arx35
  • AHX24720.1
 31436 - 31963 (+) biotin carboxyl carrier protein
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Ketide length 26
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
arx14
+
arx16
+
arx17
+
arx18
+
arx19
+
arx15 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: V5OJFE3GCDVKSA62LSGPW5E6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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