Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000200.1:
Cluster 1Polyketide / Saccharide131965

BGC0000200, arixanthomycin biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Arixanthomycin A
SMILES string: Copy to clipboard
Molecular formula: C37H37NO14
Exact molecular mass: 719.2214 Da (None)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AHX24701.1,AHX24702.1,AHX24703.1
Genes involved in folding/cyclization:
AHX24699.1, AHX24700.1, AHX24704.1

Gene cluster description

arixanthomycin (BGC0000200). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KF931341, positions 1-31965. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sean Brady (The Rockefeller University)

Literature references

1. Kang HS, Brady SF. (2014) Arixanthomycins A-C: Phylogeny-guided discovery of biologically active eDNA-derived pentangular polyphenols. ACS Chem Biol 9(6):1267-72. doi: 10.1021/cb500141b. Epub 2014 Apr