BGC0000201 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000201 (Streptomyces aureofaciens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,483	High	auricin	PKS+saccharide:hybrid/tailoring

BGC0000201 - Region 1 - T2PKS

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Location: 1 - 72,483 nt. (total: 72,483 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,484
Label		BGC0000201

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

aur1A: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

aur1G: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

aur1I: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

aur1V: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: PPTase acylase aminotransferase transferase

aur1L: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

aur1M: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

aur1N: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

aur1Q: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Lyases: cyclase dehydratase

ADM72852.2: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

aur1C: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

aur1H: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

aur1T: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

aur1D: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

aur1E: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000201.5	1.00	PKS, saccharide	auricin	Streptomyces aureofaciens
BGC0000231.5	0.85	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0000278.3	0.64	PKS	urdamycin	Streptomyces fradiae
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000201.5	1.00	PKS, saccharide	auricin	Streptomyces aureofaciens
BGC0000231.5	0.85	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.76	PKS	oviedomycin	Streptomyces antibioticus
BGC0000278.3	0.64	PKS	urdamycin	Streptomyces fradiae
BGC0002154.2	0.63	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001273.3	0.62	PKS	asperlactone	Aspergillus ochraceus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

aur1M: mal

PKS_AT (6..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 74.2
Methoxymalonyl-CoA: 33.7
Methylmalonyl-CoA: 31.4
inactive: 30.0
Isobutyryl-CoA: 14.5
trans-1,2-CPDA: 12.2
CHC-CoA: 11.4
2-Methylbutyryl-CoA: 11.1
Propionyl-CoA: 11.0
fatty_acid: 10.3
3-Methylbutyryl-CoA: 6.5
Ethylmalonyl-CoA: 1.7
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72483
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 670.9; E-value: 1.3e-204)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 335 Da
acetyl-CoA_9: 377 Da

ADM72851.2: ACP (Score: 82.0; E-value: 5.6e-26)
ADM72852.2: CYC C7-C12 (Score: 299.4; E-value: 5.3e-92)
aur1A: OXY (Score: 609.7; E-value: 8.9e-186)
aur1C: CYC C4-C17/C2-C19 (Score: 188.4; E-value: 2.8e-58)
aur1D: KS (Score: 743.4; E-value: 1.5e-226)
aur1E: CLF 8|9 (Score: 670.9; E-value: 1.3e-204)
aur1F: ACP (Score: 131.3; E-value: 2.3e-41)
aur1G: KR C9 (Score: 482.3; E-value: 7.9e-148)
aur1H: CYC C7-C12 (Score: 497.1; E-value: 3.6e-152)
aur1I: KR C15 (Score: 502.3; E-value: 5.6e-154)