BGC0000201 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000201 (Streptomyces aureofaciens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	28,528	auricin	PKS+saccharide:hybrid/tailoring	100%

BGC0000201 - Region 1 - T2PKS

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Location: 1 - 28,528 nt. (total: 28,528 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 28,529
Label		BGC0000201

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000201	1.00	Polyketide, Saccharide	auricin	Streptomyces aureofaciens
BGC0000231	0.62	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.47	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723	0.46	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001817	0.35	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000898	0.33	Saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000899	0.33	Saccharide	desosamine	Streptomyces narbonensis
BGC0000278	0.29	Polyketide	urdamycin	Streptomyces fradiae
BGC0000253	0.29	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000791	0.28	Saccharide	O-antigen	Cronobacter sakazakii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000201	1.00	Polyketide, Saccharide	auricin	Streptomyces aureofaciens
BGC0000231	0.85	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.77	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723	0.76	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001817	0.68	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000898	0.66	Saccharide	desosamine, pikromycin, neomethymycin, narbomycin	Streptomyces venezuelae
BGC0000899	0.66	Saccharide	desosamine	Streptomyces narbonensis
BGC0000278	0.63	Polyketide	urdamycin	Streptomyces fradiae
BGC0000253	0.62	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000791	0.62	Saccharide	O-antigen	Cronobacter sakazakii

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

aur1M

PKS_AT (6..296): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 74.2
Methoxymalonyl-CoA: 33.7
Methylmalonyl-CoA: 31.4
inactive: 30.0
Isobutyryl-CoA: 14.5
trans-1,2-CPDA: 12.2
CHC-CoA: 11.4
2-Methylbutyryl-CoA: 11.1
Propionyl-CoA: 11.0
fatty_acid: 10.3
3-Methylbutyryl-CoA: 6.5
Ethylmalonyl-CoA: 1.7
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 28528
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 670.9; E-value: 1.3e-204)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 335 Da
acetyl-CoA_9: 377 Da

ADM72851.2: ACP (Score: 82.0; E-value: 5.6e-26)
ADM72852.2: CYC C7-C12 (Score: 299.4; E-value: 5.3e-92)
aur1A: OXY (Score: 609.7; E-value: 8.9e-186)
aur1C: CYC C4-C17/C2-C19 (Score: 188.4; E-value: 2.8e-58)
aur1D: KS (Score: 743.4; E-value: 1.5e-226)
aur1E: CLF 8|9 (Score: 670.9; E-value: 1.3e-204)
aur1F: ACP (Score: 131.3; E-value: 2.3e-41)
aur1G: KR C9 (Score: 482.3; E-value: 7.9e-148)
aur1H: CYC C7-C12 (Score: 497.1; E-value: 3.6e-152)
aur1I: KR C15 (Score: 502.3; E-value: 5.6e-154)