BGC0000202 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000202 (Kibdelosporangium sp. MJ126-NF4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	50,393	azicemicin B	PKS	100%

BGC0000202 - Region 1 - T2PKS

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Location: 1 - 50,393 nt. (total: 50,393 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

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transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,394
Label		BGC0000202

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000202	1.00	Polyketide	azicemicin B	Kibdelosporangium sp. MJ126-NF4
BGC0000231	0.57	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.36	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000844	0.34	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000131	0.34	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001137	0.32	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0002473	0.27	NRP	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468
BGC0000196	0.27	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000202	1.00	Polyketide	azicemicin B	Kibdelosporangium sp. MJ126-NF4
BGC0000231	0.83	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.69	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000844	0.67	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000131	0.67	Polyketide	pyrrolomycin	Streptomyces sp. UC 11065
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001137	0.65	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000272	0.62	Polyketide	spore pigment	Streptomyces collinus
BGC0002473	0.61	NRP	propanochelin, butanochelin, pentanochelin	Acinetobacter bouvetii DSM 14964 = CIP 107468
BGC0000196	0.61	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

azicK

PKS_AT (8..295): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 90.7
Methylmalonyl-CoA: 44.3
Methoxymalonyl-CoA: 41.1
Propionyl-CoA: 33.0
inactive: 16.2
Ethylmalonyl-CoA: 16.1
Acetyl-CoA: 15.4
CHC-CoA: 11.8
Isobutyryl-CoA: 11.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

azicM

Search NORINE for peptide: strict or relaxed

AMP-binding (8..400): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DYYPTTMRAK
Nearest Stachelhaus code(s):: Asp DYYPTTMRAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

azicV

Search NORINE for peptide: strict or relaxed

AMP-binding (8..397): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DPYNMCIVTK
Nearest Stachelhaus code(s):: Cys DPYNMCIVTK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 50393
Starter unit(s):: aziridinyl-CoA (Score: 984.0; E-value: 0)
acetyl-CoA (Score: 73.2; E-value: 3.05e-101)
propionyl-CoA (Score: 73.2; E-value: 3.05e-101)
isobutyryl-CoA (Score: 73.2; E-value: 3.05e-101)
butyryl-CoA (Score: 73.2; E-value: 3.05e-101)
Malonyl elongations:: 8|9 (Score: 698.5; E-value: 5.1e-213)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 414 Da
acetyl-CoA_9: 456 Da
aziridinyl-CoA_8: 458 Da
aziridinyl-CoA_9: 500 Da
butyryl-CoA_8: 442 Da
butyryl-CoA_9: 484 Da
isobutyryl-CoA_8: 442 Da
isobutyryl-CoA_9: 484 Da
propionyl-CoA_8: 428 Da
propionyl-CoA_9: 470 Da

azicA: KS (Score: 748.6; E-value: 4e-228)
azicB: CLF 8|9 (Score: 698.5; E-value: 5.1e-213)
azicC: ACP (Score: 131.7; E-value: 1.6e-41)
azicD: KR C9 (Score: 471.8; E-value: 1.2e-144)
azicE: CYC C7-C12 (Score: 491.7; E-value: 1.5e-150)
azicF: KR C15 (Score: 380.0; E-value: 1.1e-116)
azicJ: CYC C4-C17/C2-C19 (Score: 161.4; E-value: 5e-50)
azicK: AT (Score: 368.9; E-value: 5.3e-113); AT AAG30190.1_R1128_acetyl-CoA/propionyl-CoA/isobutyryl-CoA/butyryl-CoA (Score: 293.0; E-value: 3.05e-101)
azicL: MET (Score: 271.3; E-value: 2.7e-83)
azicM: AT (Score: 294.3; E-value: 2.6e-90); AT ADB02855.1_Azicemicin_aziridinyl-CoA (Score: 984.0; E-value: 0.0)
azicO3: OXY (Score: 572.3; E-value: 2.1e-174)
azicO4: OXY (Score: 591.8; E-value: 2.5e-180)
azicO5: OXY (Score: 552.2; E-value: 2.6e-168)
azicO7: OXY (Score: 126.4; E-value: 3.6e-39)