BGC0000204 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000204 (Streptomyces sp. A2991200)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	17,480	High	benastatin A/benastatin B/BE-43767/TAN1532B	PKS:Type II

BGC0000204 - Region 1 - T2PKS

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Location: 1 - 17,480 nt. (total: 17,480 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,481
Label		BGC0000204

Tailoring functions

Oxidoreductases: dehydrogenase

benL: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase

benF: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: cyclase

benE: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

benH: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

benA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

benB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

benQ: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000204.5	1.00	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.58	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000234.5	0.55	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.55	PKS	spore pigment	Streptomyces avermitilis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000204.5	1.00	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001160.5	0.59	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001197.5	0.58	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002276.2	0.57	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001513.3	0.57	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000234.5	0.55	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000271.5	0.55	PKS	spore pigment	Streptomyces avermitilis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 17480
Starter unit(s):: hexanoyl-CoA (Score: 669.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 698.8; E-value: 4e-213)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: hexanoyl-CoA_11: 514 Da
hexanoyl-CoA_12: 556 Da

benA: KS (Score: 728.7; E-value: 4.4e-222)
benB: CLF 11|12 (Score: 698.8; E-value: 4e-213)
benC: ACP (Score: 91.3; E-value: 6.9e-29)
benD: CYC C5-C18 (Score: 191.3; E-value: 1.3e-59)
benE: CYC C4-C21/C2-C23|C2-C19 (Score: 169.6; E-value: 3.6e-53)
benF: MET C6|C8 (Score: 560.3; E-value: 2.8e-171)
benH: CYC C9-C14 (Score: 264.5; E-value: 5.1e-82)
benL: KR C19 (Score: 411.3; E-value: 3.2e-126)
benQ: KSIII (Score: 405.7; E-value: 3.5e-124); KSIII CAM58805.1_Benastatin_hexanoyl-CoA (Score: 669.0; E-value: 0.0)