BGC0000204: benastatin A biosynthetic gene cluster from Streptomyces sp. A2991200
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Location: 1 - 17,480 nt. (total: 17,480 nt).
This entry is originally from NCBI GenBank AM501485.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000204
Short description benastatin A biosynthetic gene cluster from Streptomyces sp. A2991200
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
AM501485.1
via Knock-out studies, Heterologous expression
Compounds
  • benastatin A
  • benastatin B
  • BE-43767
  • TAN1532B
Species Streptomyces sp. A2991200 [taxonomy]
References
Chemical products information
benastatin A Evidence:
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C30H28O7
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
benastatin B Evidence:
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C30H30O7
Chemical database entries
NPAtlas
PubCHEM
ChemSpider
BE-43767 Evidence:
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C29H26O8
TAN1532B Evidence:
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C29H28O8
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAM58794.1
  • benG
 4243 - 4698 (+) BenG protein
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    • CAM58795.1
    • benF
    		 4867 - 6045 (-) C-dimethyltransferse
    • Tailoring
    • Knock-out
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    • CAM58796.1
    • benE
    		 6112 - 6432 (+) BenE protein
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      • CAM58797.1
      • benD
      		 6432 - 6875 (+) BenD protein
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        • CAM58798.1
        • benA
        		 6865 - 8136 (+) BenA protein
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          • CAM58799.1
          • benB
          		 8133 - 9362 (+) BenB protein
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            • CAM58800.1
            • benC
            		 9436 - 9696 (+) BenC protein
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              • CAM58801.1
              • benH
              		 9698 - 10537 (+) BenH protein
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                • CAM58802.1
                • benJ
                		 10531 - 10878 (+) BenJ protein
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                  • CAM58803.1
                  • benR
                  		 11178 - 13148 (+) BenR protein
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                    • CAM58804.1
                    • benL
                    		 13292 - 14041 (-) C-19 ketoreductase
                    • Tailoring
                    • Knock-out
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                    • CAM58805.1
                    • benQ
                    		 14179 - 15189 (-) BenQ protein
                    • Precursor biosynthesis
                    • Knock-out
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                    Biosynthesis information
                    Annotation changelog

                    Entry version: 4

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-10-07
                    Update chemical activity to schema version 2.11
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 3

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2022-09-15
                    Updated bioactivity data
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 2

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2019-10-16
                    Migrated from v1.4
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    2019-10-16
                    Updated compound(s) information (NPAtlas curation)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                    Entry version: 1

                    Date
                    Changes
                    Submitters
                    Reviewers
                    2015-06-12
                    Submitted
                    • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                    Detailed domain annotation
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