BGC0000205 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000205 (Candidatus Endobugula sertula (Bugula neritina bacterial symbiont))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T3PKS,PKS-like	1	10,111	bryostatin	PKS	100%

BGC0000205 - Region 1 - PKS-like,T3PKS

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Location: 1 - 10,111 nt. (total: 10,111 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 10,112
Label		BGC0000205

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000205	2.00	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001257	0.28	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002236	0.28	Polyketide	8-methyldiaporthin	Aspergillus oryzae RIB40
BGC0002154	0.28	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001906	0.28	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001284	0.27	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002596	0.27	Polyketide	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0000107	0.27	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258	0.27	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000979	0.27	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000205	1.00	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001257	0.44	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002236	0.43	Polyketide	8-methyldiaporthin	Aspergillus oryzae RIB40
BGC0002154	0.43	Polyketide	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001906	0.43	Polyketide	naphthalene	Daldinia eschscholzii IFB-TL01
BGC0001284	0.43	Polyketide	alternariol	Parastagonospora nodorum SN15
BGC0002596	0.43	Polyketide	lecanoric acid, orsellinic acid	Claviceps purpurea 20.1
BGC0000107	0.43	Polyketide	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258	0.43	Polyketide	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000979	0.42	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

NRPS/PKS substrate predictions

bryP

PKS_AT (5..280): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 82.1
inactive: 37.9
Methoxymalonyl-CoA: 34.8
Methylmalonyl-CoA: 15.9
Propionyl-CoA: 11.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

PKS_AT (319..608): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: inactive

Prediction, score:

inactive: 34.6
Malonyl-CoA: 23.5
Methoxymalonyl-CoA: 20.2
Isobutyryl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0