LOCUS       BGC0000208             26101 bp    DNA     linear   BCT 11-JAN-2021
DEFINITION  Amycolatopsis sulphurea strain NRRL 2822 chelocardin biosynthesis
            gene cluster, complete sequence.
ACCESSION   BGC0000208
VERSION     BGC0000208
KEYWORDS    .
SOURCE      Amycolatopsis sulphurea
  ORGANISM  Amycolatopsis sulphurea
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Amycolatopsis.
COMMENT     On Dec 14, 2020 this sequence version replaced KC870000.1.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:10:59
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 26101
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..26101
                     /db_xref="taxon:76022"
                     /mol_type="genomic DNA"
                     /organism="Amycolatopsis sulphurea"
                     /strain="NRRL 2822"
     misc_feature    1..26101
                     /note="chelocardin biosynthesis gene cluster"
     subregion       1..26101
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26101
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            452..1399
                     /gene="orf1"
     CDS             452..1399
                     /codon_start=1
                     /gene="orf1"
                     /product="hypothetical protein"
                     /protein_id="QPT54834.1"
                     /transl_table=11
                     /translation="MPLRQAATAAGLITGYFADTWFGDPRRGHPVAGFGTVAAALEQRW
                     WADSKSRGAVYAGACAGAATGLGLAAQMATRRRPLARFALTAAATWVVLGGRGLAAEGR
                     EMARLLESGEVPAARERLGHLCARDATGLDAAELSRAATESIAENTSDAVVAPLLWGAV
                     AGIPGLLGYRAVNTLDAMVGYRSPRHRNFGWFAARTDDLVNLVPSRAGALLTTAVAPLA
                     GGRSRTAWRTWRRDGSAHPSPNAGQVEAAFAGALGIRLGGTNSYHGETERRGTLGDGRP
                     PGPADLRRAVRLSRVVGAAALVVAAAGVFGVRAR"
     gene            1396..2874
                     /gene="orf2"
     CDS             1396..2874
                     /codon_start=1
                     /gene="orf2"
                     /product="hypothetical protein"
                     /protein_id="QPT54835.1"
                     /transl_table=11
                     /translation="MSGLLIAGTTSDAGKSLVTAGICRWLARRGVRVAPFKAQNMSNNS
                     MVCADGAEIGRAQWLQARAAGVEPEAAMNPVLLKPGSDRRSHVVALGKPFGTLEAGEYA
                     TGRAGLAEIAFTAFAGLRERFDVVVCEGAGSPAEINLRRGDYVNLGLARRFSLPVLVVG
                     DIDRGGVLAAMFGTLALLSAEDQALVAGWLVNKFRGDVGLLRPGLDSLAKVTGRPVLGV
                     LPWLDRVWIDSEDALAAAGWRHEAASGGLRVAVVRFPRASNATDVDALAAEPGVTVSLT
                     ADPDTVAAADLVVLPGSRATVDDLHWLRARGLADAVTARAAAGRPVLGICGGYQMLAES
                     IEDDVESGAGLVPGLGLLPTKVSFAGEKVLGRPSGSWRGHPVDAYEIHHGSAGPADAES
                     FLDGYRAGAVWGTTWHGALENDGFRRAWLTEVAAQAGLTWAPAPGAPGFAALREDMLDR
                     LADAIESGVDTERLLDLVTGGAPAGLPFVPPGAP"
     gene            3079..4377
                     /gene="chdP"
     CDS             3079..4377
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-399). E-value:
                     1.3e-51. Score: 167.6. Matches aSDomain:
                     nrpspksdomains_chdP_PKS_KS.1"
                     /codon_start=1
                     /gene="chdP"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 469.8; E-value:
                     1.3e-142)"
                     /gene_kind="biosynthetic"
                     /product="putative keto-acyl synthase alpha"
                     /protein_id="AHD25926.1"
                     /sec_met_domain="t2ks (E-value: 1.9e-231, bitscore: 758.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPSDAHRVVITGIGVVAPGDRGTKQFWELITAGRTATRPISLF
                     DASSFRSRVAAECNFDPIAAGLSQRQIRKWDRTTQFCVVAAREAVADSGMLGEQDPLRT
                     GVAIGTACGMTQSLDREYAVVSDEGSSWLVDPDYGVPQLYDYFLPSSMATEIAWLVEAE
                     GPVGLVSTGCTSGVDVIGHAADLIRDGEADIMVAGASEAPISPITVACFDAIKATTARN
                     HEPESASRPFDQTRSGFVLGEGAAVFVLEELRHAKRRGAHIYAEIVGYASRCNAYSMTG
                     LRPDGREMADAIDGALNQARIDPSRIGYVNAHGSSTRQNDRHETAAIKTSLGAHAYQVP
                     VSSIKSMVGHSLGAIGSLEVAACALTIEHSVIPPTANLHVPDPECDLDYVPLVAREQEV
                     DVVLSVASGFGGFQSAILLTGPDGRTGKRVTQR"
     aSDomain        3106..4275
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdP_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.30E-51"
                     /label="chdP_PKS_KS.1"
                     /locus_tag="chdP"
                     /protein_end="399"
                     /protein_start="9"
                     /score="167.6"
                     /tool="antismash"
                     /translation="VVITGIGVVAPGDRGTKQFWELITAGRTATRPISLFDASSFRSRV
                     AAECNFDPIAAGLSQRQIRKWDRTTQFCVVAAREAVADSGMLGEQDPLRTGVAIGTACG
                     MTQSLDREYAVVSDEGSSWLVDPDYGVPQLYDYFLPSSMATEIAWLVEAEGPVGLVSTG
                     CTSGVDVIGHAADLIRDGEADIMVAGASEAPISPITVACFDAIKATTARNHEPESASRP
                     FDQTRSGFVLGEGAAVFVLEELRHAKRRGAHIYAEIVGYASRCNAYSMTGLRPDGREMA
                     DAIDGALNQARIDPSRIGYVNAHGSSTRQNDRHETAAIKTSLGAHAYQVPVSSIKSMVG
                     HSLGAIGSLEVAACALTIEHSVIPPTANLHVPDPECDLDYVPLVAREQEV"
     gene            4374..5630
                     /gene="chdK"
     CDS             4374..5630
                     /NRPS_PKS="Domain: PKS_KS(Trans-AT-KS) (80-414). E-value:
                     4e-25. Score: 80.4. Matches aSDomain:
                     nrpspksdomains_chdK_PKS_KS.1"
                     /codon_start=1
                     /gene="chdK"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 642; E-value:
                     5.3e-195)"
                     /gene_kind="biosynthetic"
                     /product="putative keto-acyl synthase beta"
                     /protein_id="AHD25927.1"
                     /sec_met_domain="t2clf (E-value: 3e-202, bitscore: 662.0,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVETEPAPVPGRSTVRPVVTGLGVIAPNGMGTEAYWAATLRGDS
                     GLRRITRFDPDGYPARIAGEVSFDPAGRLPDRLLPQTDHMTRLALIAAEEALADAGADP
                     RNLPDYATGVMTAASGGGFEFGQRELQELWSKGGSYVSAYQSFAWFYPVNTGQISIRHG
                     MRGSSGTLVSEQAGGLDAVAKARRHVRDGTPLMVTGGIDGSLCPWSWLCMLRSGRLSTA
                     SDPQRAYLPFDTEASGMVPGEGGALLVIEDPAAAQRRGVDRIYGQIAGYCATFDPGPGS
                     RRPPGLRRAVEQALAEARLHPSEVDVVFADAAGLPDLDRAEIEVLVRIFGARAVPVTAP
                     KTMTGRLLAGGSSLDLATALLSLRDKVIPPTVHIGKFGYRDEIDLVRDSPRQAPLSTAL
                     VLARGYGGFNSAMVLRGAT"
     aSDomain        4614..5615
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdK_PKS_KS.1"
                     /domain_subtypes="Trans-AT-KS"
                     /evalue="4.00E-25"
                     /label="chdK_PKS_KS.1"
                     /locus_tag="chdK"
                     /protein_end="414"
                     /protein_start="80"
                     /score="80.4"
                     /tool="antismash"
                     /translation="QTDHMTRLALIAAEEALADAGADPRNLPDYATGVMTAASGGGFEF
                     GQRELQELWSKGGSYVSAYQSFAWFYPVNTGQISIRHGMRGSSGTLVSEQAGGLDAVAK
                     ARRHVRDGTPLMVTGGIDGSLCPWSWLCMLRSGRLSTASDPQRAYLPFDTEASGMVPGE
                     GGALLVIEDPAAAQRRGVDRIYGQIAGYCATFDPGPGSRRPPGLRRAVEQALAEARLHP
                     SEVDVVFADAAGLPDLDRAEIEVLVRIFGARAVPVTAPKTMTGRLLAGGSSLDLATALL
                     SLRDKVIPPTVHIGKFGYRDEIDLVRDSPRQAPLSTALVLARGYGGFNSAMVL"
     aSModule        4614..5891
                     /complete
                     /domains="nrpspksdomains_chdK_PKS_KS.1"
                     /domains="nrpspksdomains_chdS_ACP.1"
                     /locus_tags="chdK"
                     /locus_tags="chdS"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       5067..5105
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chdK_0001"
                     /evalue="7.70E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="chdK"
                     /protein_end="244"
                     /protein_start="231"
                     /score="9.7"
                     /tool="antismash"
                     /translation="FDTEASGMVPGEG"
     gene            5655..5921
                     /gene="chdS"
     CDS             5655..5921
                     /NRPS_PKS="Domain: ACP (10-79). E-value: 8.6e-17. Score:
                     53.1. Matches aSDomain: nrpspksdomains_chdS_ACP.1"
                     /codon_start=1
                     /gene="chdS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 109.8; E-value:
                     8.7e-34)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl carrier protein"
                     /protein_id="AHD25928.1"
                     /sec_met_domain="PP-binding (E-value: 3.2e-13, bitscore:
                     40.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEFTIAELVRLLRECAGEEEGVDLDGEVGDLPFDELGYDSLALF
                     NTIGRIEREYTVDLPEDVVWQATTPGALVDLVNSSRTSPAAAD"
     aSDomain        5685..5891
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdS_ACP.1"
                     /evalue="8.60E-17"
                     /label="chdS_ACP.1"
                     /locus_tag="chdS"
                     /protein_end="79"
                     /protein_start="10"
                     /score="53.1"
                     /tool="antismash"
                     /translation="RLLRECAGEEEGVDLDGEVGDLPFDELGYDSLALFNTIGRIEREY
                     TVDLPEDVVWQATTPGALVDLVNS"
     gene            complement(5993..6901)
                     /gene="chdQI"
     CDS             complement(5993..6901)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (7-144). E-value:
                     3.7e-11. Score: 35.4. Matches aSDomain:
                     nrpspksdomains_chdQI_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="chdQI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 228.6; E-value:
                     1.9e-69)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cyclase/aromatase"
                     /protein_id="AHD25929.1"
                     /transl_table=11
                     /translation="MSHPEAEQTQASIVVDAPAEITYAMLVDVANWPLLYPWIAHTEFV
                     ERAPTEDLVQFWAVNPLGRIRIWTSRRYLDASALRMDIEQQGSVGPITGLTGSWTFKPL
                     PGDRCLVESRHAFHAATPEDRAAGVTELNRHGKLQMETLKSRVENRTRLAELTWSFEDS
                     LVIESELGQVYRALRDVGSWPAHLPCLTALEVTEDENDVQFYDVRTQDADEPSRFVRIC
                     LPDKGIAYKQLTVTAPVDLHLGRWTLTETPAGVAVTSAHTVLVNPSAAEQLPELRDRLH
                     KTSSADSLAELQLVKRLAETR"
     aSDomain        complement(6470..6880)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdQI_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="3.70E-11"
                     /label="chdQI_Polyketide_cyc2.1"
                     /locus_tag="chdQI"
                     /protein_end="144"
                     /protein_start="7"
                     /score="35.4"
                     /tool="antismash"
                     /translation="QTQASIVVDAPAEITYAMLVDVANWPLLYPWIAHTEFVERAPTED
                     LVQFWAVNPLGRIRIWTSRRYLDASALRMDIEQQGSVGPITGLTGSWTFKPLPGDRCLV
                     ESRHAFHAATPEDRAAGVTELNRHGKLQMETLK"
     gene            complement(6990..8021)
                     /gene="chdMII"
     CDS             complement(6990..8021)
                     /NRPS_PKS="Domain: oMT (139-271). E-value: 1.9e-07. Score:
                     21.3. Matches aSDomain: nrpspksdomains_chdMII_oMT.1"
                     /codon_start=1
                     /gene="chdMII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 191.5; E-value:
                     4e-58)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative methyltransferase"
                     /protein_id="AHD25930.1"
                     /transl_table=11
                     /translation="MTETEPTTVTAKKLHEIMRGYVKTALLRTAIELNIFDGIGDRTVD
                     ADGLARALGVDARGLRITLDSLAAIGLLRTVDGKYALPVDGDKFLLSSSPTFFGPSLKL
                     GASDWEWDAQKRLTEAVRKGGAVMDSHALTPEFDYWEDFAENTTWFNNGAAELMAEQLL
                     PWAKDRDSVDVLDVACSHGYYGVNLAKAEPKARVWGVDWPNVLPITAKNYERNGISDRF
                     EGIPGDMFSVPLGGPYDVVMITNVLHHFSADTSTNLLRRLFDVLKPGGRIAVTGHTFVE
                     GERPEDKPLPYLFSQIMLVMTDEGETHSTKTYERMFTDAGFVNPQIFTAEKAMHTVFTA
                     DKA"
     aSDomain        complement(7209..7604)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdMII_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="1.90E-07"
                     /label="chdMII_oMT.1"
                     /locus_tag="chdMII"
                     /protein_end="271"
                     /protein_start="139"
                     /score="21.3"
                     /tool="antismash"
                     /translation="WEDFAENTTWFNNGAAELMAEQLLPWAKDRDSVDVLDVACSHGYY
                     GVNLAKAEPKARVWGVDWPNVLPITAKNYERNGISDRFEGIPGDMFSVPLGGPYDVVMI
                     TNVLHHFSADTSTNLLRRLFDVLKPGGR"
     gene            8185..9384
                     /gene="chdGIV"
     CDS             8185..9384
                     /codon_start=1
                     /gene="chdGIV"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 215.7;
                     E-value: 2.2e-65)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative glycosyltransferase"
                     /protein_id="AHD25931.1"
                     /sec_met_domain="MGT (E-value: 1.9e-86, bitscore: 281.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLLLVTWNAPAHLFAMVPLGWAAQVAGHEVRVAAPPSCTEAIGR
                     TGLTAVPVGTQRPAAPSGPPPGAPSGRWPVDWAVHPELLDDSRHELLRSLAARQFAAAE
                     PMLDDLIEFARWWSPDVVVYDPTSLAGEVAATVLGVPAFACSWGRAAAVRIERGLGSEP
                     LLGYARLFERFGCQAPQGPASWFDPFPAGLWLAEPDLPRQAMRFVPGTGGDAGSLPGWL
                     REHSARPRICVTSAEPGGLLRPEAVRAFYRHALTVLSDVDAEVVVPAGPAARTLLAEIP
                     HTARIVDPVAAHLLVPACRLTVHQGDGLSTLAGLNSGVPQYVLAPRPEQELVGHQLHRA
                     GAGGYRSLSEPVDVPAERAVLDALLAPESGGAAARKLQEETLALPLPSAVLGRIESATR
                     "
     gene            9589..11124
                     /gene="chdTn"
     CDS             9589..11124
                     /codon_start=1
                     /gene="chdTn"
                     /product="putative transposase"
                     /protein_id="AHD25932.2"
                     /transl_table=11
                     /translation="MSVHGVMPSGWSSPVGRLLSQAGLGLLSWVVPPALVDEALAVAGR
                     DERRFRALPSRLGVYFVLALCLLRTKSGNATIRAMFSQESLPRLSVLGWWPPASTALTK
                     LRDRIGVVPFQLLFGALARAAPTRNRPWSHAFGLEVCAWDGTEVEPADTAANREHFPPH
                     HRTGVARGPSKIRVLVLLSCGSRRLLGAVTGPLSQGEPTLAYQLLPRLHDRMLLLADRC
                     FLGYPLWTAARERGAHLLWRAKQNTPKLPVQHALPDESWLSTLHAPADARRWARNVRRN
                     KQRGHRPPTPRPINGIVVRVVEALITVTVDGVTRTEKYRLVTSLLDPAHAPAGQLVALY
                     ARRWTAETGIKEIKTTLLAKRPLRGHTPIRAQQELWATLIVYQAIRLLISHAALTQNLD
                     PSRISFTSARDAAEHAITTTPADTSRHLQWVAQDLCRQLITVHTHHRVYPRALKRTTTR
                     YPHRSKTPQPTSTKASYQVHILPTAETTPPTTTKPTPHQPRTDLSSWHWTQSP"
     gene            complement(11263..12708)
                     /gene="chdR"
     CDS             complement(11263..12708)
                     /codon_start=1
                     /gene="chdR"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 312.1; E-value:
                     8.1e-95)"
                     /gene_kind="transport"
                     /product="putative exporter"
                     /protein_id="AHD25933.1"
                     /transl_table=11
                     /translation="MKDNLARPDTVGADENRISPALWGLASILILGGFTSMFTSTIVNV
                     ALDTLSQKLSAPLGTVQWTATGYLMALATAVPVSGWASKRYGATRLWLGSVALFTLFSA
                     LCALSTSVEMLITFRVLQGIAGGLLVPAGQILLVTAAGPKRIGRMLTAVSVPIYLAPAV
                     GTTLGSVLTQGLGWPWLFWITVPLGALGFFAGLRWLPKAPPKGAPALDVRGLIILVAGL
                     PLLTYGVAGIGENGGRTETIAVIAAVAGALLLALFTLHAVRSRNPLLNLRLFKDRAFSS
                     AAVVIFCMGIALFGAMIVLPIYFLQVRHEDLVTAGLLTAPSAIGTVLALPLAGKMTDKI
                     GGARVIFAGLVVTIIGTIPLALVTPHDSYVWLSLVQIVRGIGIGMTTTPAMAAGLAMIG
                     KEDVPHATPIFNVLQRVGGSFGTALTTVLVAFQLASGPQTDEGAADAIGYTHWWIVACT
                     AIVLIPSMLLVQVESRRRQAAAA"
     gene            12859..13431
                     /gene="chdA"
     CDS             12859..13431
                     /codon_start=1
                     /gene="chdA"
                     /gene_functions="regulatory (smcogs) SMCOG1239:TetR family
                     transcriptional regulator (Score: 104.6; E-value: 1.1e-31)"
                     /gene_kind="regulatory"
                     /product="putative transcriptional regulator"
                     /protein_id="AHD25934.1"
                     /transl_table=11
                     /translation="MRLSPETFARAALKLLNKSGLEGVSLRKLGDELGVQGPALYAHFK
                     NKQELLDLMAEIMLDEALAPLDAMTEVADWHWWLAERARTIRRTLLSYRDGALLHAGSR
                     PTADGAEAIPALLRPLREAGFSDKEALTVIITIGRYTLGCVIDEQRPGEPAPQPGPGAD
                     DTFEFGLQALLAGLRARLPERVPDSAG"
     gene            complement(13445..14791)
                     /gene="chdN"
     CDS             complement(13445..14791)
                     /NRPS_PKS="Domain: Aminotran_1_2 (87-436). E-value:
                     1.3e-20. Score: 65.7. Matches aSDomain:
                     nrpspksdomains_chdN_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="chdN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 275.8; E-value:
                     9.9e-84)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aminotransferase"
                     /protein_id="AHD25935.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-21, bitscore:
                     65.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTMTKAREDLTTGSAVTLELAGLHTGVSDPRMDSMRLLSETAFRY
                     PQAVSFASGRPYEGFFDIAKLHHYLDRFVEHLRERGMPEERIKKALFQYGPINGLIRDM
                     IARTLEVDEDIHVAPEAVMVTHGCQEAMMIALRGLFASPSDVLLTVSPCYVGIAGAAKM
                     LDIPMAAVPEGAEGIDPEQVAAVAREVRASGLRPVACYVTPDFSNPSGHSLPIATRHRL
                     LEVAAEQDLLLLEDNPYGLFGRDGAQVPTLKALDTQRRVIYLGSFAKTVFPGARVGYLV
                     ADQEVTGGPGAAKPLAEELGKVKSMFTVGTSGISQALVGGVLLDADFSLRTANRELADL
                     YVRHLEVTLSSLAEHFPPERFAEHGVRWNVPGGGFFLSVEVPFVAGLEALDRSARDHGV
                     GWAPMSMFYVGDGGEHIVRLGFSPLTAEEIREGVRRLAEFVKATPRTDR"
     aSDomain        complement(13484..14530)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdN_Aminotran_1_2.1"
                     /evalue="1.30E-20"
                     /label="chdN_Aminotran_1_2.1"
                     /locus_tag="chdN"
                     /protein_end="436"
                     /protein_start="87"
                     /score="65.7"
                     /tool="antismash"
                     /translation="KKALFQYGPINGLIRDMIARTLEVDEDIHVAPEAVMVTHGCQEAM
                     MIALRGLFASPSDVLLTVSPCYVGIAGAAKMLDIPMAAVPEGAEGIDPEQVAAVAREVR
                     ASGLRPVACYVTPDFSNPSGHSLPIATRHRLLEVAAEQDLLLLEDNPYGLFGRDGAQVP
                     TLKALDTQRRVIYLGSFAKTVFPGARVGYLVADQEVTGGPGAAKPLAEELGKVKSMFTV
                     GTSGISQALVGGVLLDADFSLRTANRELADLYVRHLEVTLSSLAEHFPPERFAEHGVRW
                     NVPGGGFFLSVEVPFVAGLEALDRSARDHGVGWAPMSMFYVGDGGEHIVRLGFSPLTAE
                     EIREGVRRL"
     gene            14924..16138
                     /gene="chdOI"
     CDS             14924..16138
                     /codon_start=1
                     /gene="chdOI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 224.8; E-value:
                     3.8e-68)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative oxygenase"
                     /protein_id="AHD25936.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.6e-09, bitscore:
                     27.9, seeds: 64, tool: rule-based-clusters)"
                     /sec_met_domain="DAO (E-value: 2.8e-09, bitscore: 27.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIRTDFCVVGGGPAGLTLALLLARSGVRVVVVERSRSFDREYR
                     GEILQPGGQALLAELGVLTPAREHGAHEHHRFLLEEHGKVLINGDYRRLPGPFNCLLSI
                     PQRHLLRELLAQCHEHAGFQYLSGTKVTGLVEDGGRVRGVVCGDDQVVLAHCVIGADGR
                     YSKVRQLAGIPADRVEGFRQDVLWFKLSADGELPSEVRVFRAGGNPVLAYTSVRDRVQF
                     GWTLPHKGYQLLAQQGLAHIKEQLRAAVPGYADRIDEEITSFRDLSLLDVFSGGARQWV
                     RDGLLLIGDSAHTHGPIGAQGINLAIQDAVAAHPLLLESLRANDSSGAMLGRFVTGRKR
                     DIDRMNRIQAVQGKAMLSAGRVSSVVRPRLAMVVARTPIYRAMLRQIAFGNTGIRIRAE
                     LFARR"
     gene            complement(16146..17171)
                     /gene="chdMI"
     CDS             complement(16146..17171)
                     /codon_start=1
                     /gene="chdMI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 283.9; E-value:
                     3e-86)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative methyltransferase"
                     /protein_id="AHD25937.1"
                     /transl_table=11
                     /translation="MTGTVLPAAVMRVRELALSAACAASVRAAAKLGLADVLDDQPATV
                     DELAKAVHADPGALRRLMRSLTCFEVFAEPEPDKFVHTDASRLLREDAPRSLKHILLWG
                     TEPWTWELWPHLDQAVRTGKNVFDDLHGKDFFEYLHEQWPESAEVFDKAMTQSSKLSAL
                     AIADRLDLTGAERLADIAGGQGNVLATLLSRNEKLNGVLFDLPAVVAGADERLRVGGAL
                     ADRAELVAGDCRREIPVQADVYLFKNILEWDDESTVLALRNAVAAGRPGARVVIIENLV
                     DGTPEMKFATAMDLLLLLNVGGKKHTKDGLLGLIGQAGLQVDRVSAVNSYLHMVETTIP
                     G"
     gene            complement(17249..19180)
                     /gene="chdL-chdOIII"
     CDS             complement(17249..19180)
                     /NRPS_PKS="Domain: AMP-binding (35-435). E-value: 6.4e-79.
                     Score: 257.2. Matches aSDomain:
                     nrpspksdomains_chdL-chdOIII_AMP-binding.1"
                     /codon_start=1
                     /gene="chdL-chdOIII"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     320.3; E-value: 3.1e-97)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl-CoA ligase/oxygenase fusion
                     protein"
                     /protein_id="AHD25943.1"
                     /sec_met_domain="AMP-binding (E-value: 3.8e-90, bitscore:
                     292.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATPETTVAQDSTVSGDPLTGIAGFIGGPRVDDLLRSAAERAPEH
                     VAIRAAACELSYAALDERAGRLARAVHAQLAEPGQVVALAGVLDPAFAVSFFGIARSGA
                     VPALINPLLLADGLVHVLGTSGAVTAIVPPEVHRRLVPVLDRLPELRHLVLTHRDDQTE
                     PSGPPTLDEVLASAPDGVLPATTCDENSVACLQFTSGTTGAAKAVRLSHRNITVNAAQS
                     GHAHGITPSSVLFNYLPTFHLMHLTMAVTFAATLVLHVGDDVAQAVDAADNEKATHFYS
                     LPMRLSRLAVHPRLSTLAADALQVILCGGSALPLPSTRALTGCFGVPVVQGYGLQETSP
                     STHFDSLSCPKTGSSGRPVAGTGCRIVDVDSRAVLPVGEKGEIQVRGPQLMLGYLGREP
                     GQDVDPDGWFSTGDVGYVDAEGVLFVVDRIKDVFKCDNWLVSPTEIERVVLSHPEVADC
                     VVLDYPDDFSGSVAYGLVVPKGAGLNPAQLAEFVAERLPYYAHLRHVELTDRIPRSPNG
                     KLQRRALREQIHARNADGASEIARQNRSKTVFTFINRFTVTGDATEFRRLLGQITAHMT
                     AQPGFRSHRLYQSARDEAVFTEIAEWDSAEDHQRATAGKGFREPVGEAMKHATAEPAPF
                     VLRAEHGA"
     aSDomain        complement(17876..19075)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdL-chdOIII_AMP-binding.1"
                     /evalue="6.40E-79"
                     /label="chdL-chdOIII_AMP-binding.1"
                     /locus_tag="chdL-chdOIII"
                     /protein_end="435"
                     /protein_start="35"
                     /score="257.2"
                     /tool="antismash"
                     /translation="RSAAERAPEHVAIRAAACELSYAALDERAGRLARAVHAQLAEPGQ
                     VVALAGVLDPAFAVSFFGIARSGAVPALINPLLLADGLVHVLGTSGAVTAIVPPEVHRR
                     LVPVLDRLPELRHLVLTHRDDQTEPSGPPTLDEVLASAPDGVLPATTCDENSVACLQFT
                     SGTTGAAKAVRLSHRNITVNAAQSGHAHGITPSSVLFNYLPTFHLMHLTMAVTFAATLV
                     LHVGDDVAQAVDAADNEKATHFYSLPMRLSRLAVHPRLSTLAADALQVILCGGSALPLP
                     STRALTGCFGVPVVQGYGLQETSPSTHFDSLSCPKTGSSGRPVAGTGCRIVDVDSRAVL
                     PVGEKGEIQVRGPQLMLGYLGREPGQDVDPDGWFSTGDVGYVDAEGVLFVVDRIKDVFK
                     C"
     CDS_motif       complement(17987..18055)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chdL-chdOIII_0002"
                     /evalue="1.80E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="chdL-chdOIII"
                     /protein_end="398"
                     /protein_start="375"
                     /score="20.3"
                     /tool="antismash"
                     /translation="PVGEKGEIQVRGPQLMLGYLGRE"
     CDS_motif       complement(18545..18604)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chdL-chdOIII_0001"
                     /evalue="1.40E-05"
                     /label="NRPS-A_a3"
                     /locus_tag="chdL-chdOIII"
                     /protein_end="212"
                     /protein_start="192"
                     /score="17.8"
                     /tool="antismash"
                     /translation="ACLQFTSGTTGAAKAVRLSH"
     gene            complement(19206..19658)
                     /gene="chdX"
     CDS             complement(19206..19658)
                     /codon_start=1
                     /gene="chdX"
                     /product="putative cyclase"
                     /protein_id="AHD25939.1"
                     /transl_table=11
                     /translation="MSQAVQAVGSTEDIALYVEVQQFYGRQMRYLDEGRVQEWAKTFTE
                     DGMFAANAHPEPARGRTAIEAGALEAATRLAEQGIQRRHWLGMVQVDPQPDGSIVAKSY
                     AVIIGTPLGGKAAVDLSCDCVDVLVREGGALLVRERQVYRDDLPRN"
     gene            19823..20611
                     /gene="chdT"
     CDS             19823..20611
                     /NRPS_PKS="Domain: PKS_KR (8-120). E-value: 1.5e-11. Score:
                     36.4. Matches aSDomain: nrpspksdomains_chdT_PKS_KR.1"
                     /codon_start=1
                     /gene="chdT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     242.6; E-value: 7.4e-74)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative ketoreductase"
                     /protein_id="AHD25940.1"
                     /sec_met_domain="adh_short (E-value: 8.6e-38, bitscore:
                     120.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSTEEPRVALVTGATSGIGLAVTKALAARGLRVFICARNRENVV
                     STVKELRAQGLDVDGQAGDVRSVAAVREVVESAVNRFGTISVLVNNAGRSGGGITAKIT
                     DELWQDVIDTNLNSVFTVTREVLTTGGLDGADGGRIINIASTGGKQGVPLGAPYSAAKS
                     GVIGFTKALGKELAKTGVTVNAVCPGYVETPMAVRVRQAYASTWDTTDENVLARFNDKI
                     PLGRYCTPEEVAGMVDYLVADTAASVTAQAINVCGGLGNY"
     aSDomain        19847..20182
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdT_PKS_KR.1"
                     /evalue="1.50E-11"
                     /label="chdT_PKS_KR.1"
                     /locus_tag="chdT"
                     /protein_end="120"
                     /protein_start="8"
                     /score="36.4"
                     /tool="antismash"
                     /translation="VALVTGATSGIGLAVTKALAARGLRVFICARNRENVVSTVKELRA
                     QGLDVDGQAGDVRSVAAVREVVESAVNRFGTISVLVNNAGRSGGGITAKITDELWQDVI
                     DTNLNSVF"
     CDS_motif       19853..19921
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_chdT_0001"
                     /evalue="4.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="chdT"
                     /protein_end="33"
                     /protein_start="10"
                     /score="19.4"
                     /tool="antismash"
                     /translation="LVTGATSGIGLAVTKALAARGLR"
     gene            20640..21587
                     /gene="chdQII"
     CDS             20640..21587
                     /NRPS_PKS="Domain: Polyketide_cyc2 (6-149). E-value:
                     2.6e-13. Score: 42.5. Matches aSDomain:
                     nrpspksdomains_chdQII_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc2 (159-311). E-value:
                     1.5e-11. Score: 36.8. Matches aSDomain:
                     nrpspksdomains_chdQII_Polyketide_cyc2.2"
                     /codon_start=1
                     /gene="chdQII"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 424.7; E-value:
                     3.7e-129)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cyclase/aromatase"
                     /protein_id="AHD25941.1"
                     /transl_table=11
                     /translation="MPAAAQQHTEHRIDIDAPAGLVYRIIADATEWPRHFTPTVHVDQS
                     ELDGHTERLHIWANANGQLKSWTSLRELDERAGRIRFRQEVSAPPVASMSGEWIVSERV
                     AERTTLVLTHDFAAVDDDPAGVEWITKATNGNSDTELANIKALAERWERMDRLAFDFED
                     SVLVRAPKERAYHFLDRVDLWPDRLPHVARLELREDVPGVQHMSMDTKAKDGSTHTTVS
                     VRVCFPEARIVYKQLVPPALLTTHTGVWTFEDTADGVLVTSAHTVVLNEANIGTVPGPA
                     ATVESTRDFVRNAISGNSQATLRHAKAFAEATDA"
     aSDomain        20658..21086
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdQII_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="2.60E-13"
                     /label="chdQII_Polyketide_cyc2.1"
                     /locus_tag="chdQII"
                     /protein_end="149"
                     /protein_start="6"
                     /score="42.5"
                     /tool="antismash"
                     /translation="QHTEHRIDIDAPAGLVYRIIADATEWPRHFTPTVHVDQSELDGHT
                     ERLHIWANANGQLKSWTSLRELDERAGRIRFRQEVSAPPVASMSGEWIVSERVAERTTL
                     VLTHDFAAVDDDPAGVEWITKATNGNSDTELANIKALAE"
     aSModule        20658..21572
                     /domains="nrpspksdomains_chdQII_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_chdQII_Polyketide_cyc2.2"
                     /incomplete
                     /locus_tags="chdQII"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        21117..21572
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_chdQII_Polyketide_cyc2.2"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.50E-11"
                     /label="chdQII_Polyketide_cyc2.2"
                     /locus_tag="chdQII"
                     /protein_end="311"
                     /protein_start="159"
                     /score="36.8"
                     /tool="antismash"
                     /translation="DFEDSVLVRAPKERAYHFLDRVDLWPDRLPHVARLELREDVPGVQ
                     HMSMDTKAKDGSTHTTVSVRVCFPEARIVYKQLVPPALLTTHTGVWTFEDTADGVLVTS
                     AHTVVLNEANIGTVPGPAATVESTRDFVRNAISGNSQATLRHAKAFAE"
     gene            21580..24000
                     /gene="chdOII-chdY"
     CDS             21580..24000
                     /codon_start=1
                     /gene="chdOII-chdY"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 405; E-value:
                     8.9e-123)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative oxygenase/cyclase fusion protein"
                     /protein_id="AHD25942.2"
                     /transl_table=11
                     /translation="MPEDSGEEPEVLVAGAGPVGLTAAHELARRGVRVRLVDRSAGPAT
                     TSRALATHARTLEIWHQMGLLGELLPRGRRVEHFTLHLKGKTLMCFDTNYDTMPTRFPF
                     SLMVDQVVTEEVLRRQVRALGVTVEWGVELTWFDQEPDGVLAELRHADGTVEQVTAAWL
                     VGADGARSTVRKRLDLRLQGDSTQTWLNADVVLDTDLAGDSNHLLHTGRGTLLLVPFPE
                     PGKWRVVDTEDTDHADDARIVRARLADKLTRALGRPIEVPEPSWISVFTVQQRMIDRMR
                     AGRCFVAGDAAHVHSPASGQGMNTGIQDAYNLAWKLADVVRGHAKESLLDSYGAERVPI
                     GETLLRTTRTATALVSLRNTVAPLVMPAGTRLLGALKPLKRRIERTMIRGFCGLTLNYT
                     HSPLSLACATPDGIQPGHRVGCSVDRARTSPGWQGLVTELTDPRWTLLAFADSQEQRQI
                     AAQVERRYGKAVSVRVVAEAATSERVLADPGDDLARDFAMRAGYFVLIRPDGHLAAKGR
                     LSDDLDGAFGALGLVPADAGGDPAHHLDSEGSRMRIIDLSATMDAADRWEANPVTHEVL
                     TAAEGAQHMAAEMKEHFGIDFDPSVLPGGELLTLDTLTLTTHTGTHVDAPSHYGTPRDG
                     VARHIDQMPLEWFLRPGVVLDLTGEPVGAAGADRLREEFERIGYTPKPLDIVLLNTGAD
                     ALAGSPKYFTDFTGLDGKATELLLDLGVRVIGTDAFSLDAPFGHMIAEYRRTGDRSVLW
                     PAHFAGRDREYCQIEGLTNLAALPSPTGFSVSCLPVKIAGAGAGWTRAVALLD"
     gene            24167..24943
                     /gene="chdB"
     CDS             24167..24943
                     /codon_start=1
                     /gene="chdB"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     309.2; E-value: 1.2e-93)"
                     /gene_kind="regulatory"
                     /product="SARP family transcriptional regulator"
                     /protein_id="QPT54836.1"
                     /transl_table=11
                     /translation="MKFNLLGPMEVLCADGTVTPSAAKMRWILALLLLHGNRVVDQASM
                     IDELWGDHPPRSAVTTTQTYVYQLRKKYDYYAQREGRKSFIVTRAPGYLLQLDDDQLDV
                     RRFQRLSAEGSALFSAGHAERADEVLRQALRLWRGPALAGIAPGRMLQAHVAYLEEARL
                     RTVQVRILADAALGRHRDLIPELRSLVIEHPLDEWFHQQLITALAEAGRRGDALHACRV
                     LHRTLADELGVAPSEPLRKLQQDLLTGHVRRAPAHV"
     gene            complement(24987..25625)
                     /gene="chdC"
     CDS             complement(24987..25625)
                     /codon_start=1
                     /gene="chdC"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 100.1; E-value:
                     1.7e-30)"
                     /gene_kind="regulatory"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="QPT54837.1"
                     /transl_table=11
                     /translation="MITDRVRILIVEESSVFRVGLLSLIQGADDLAAIDAVATIGEALD
                     SVSRGIVDVILYGVDGWGPEVESGLLELSAAAPGKPVVILSQENRFGFIQEFLGIGVRG
                     YLPKNVSDMYLLSVVREVSRDERCVFLSVPSVDVRSLSSNLRTPLSRREHEIMSLVARG
                     MTNAQIGNCLAITQGTVKRHLRNIFVKLNAVSRLDAVNKAQTAAPLVPA"
ORIGIN
        1 aattctccag ccgttcgtcg agccgctgct cccagccggc ctgcccggac cacgcgccga
       61 cctcgtcgag caccctggac agccaggtgc ccaggcagtc gatgagcagc ggactggtcg
      121 cggtgcgcag cactttcgcc aggtcggtgg tctccaccgt ggtccagtgg tgcggccggc
      181 gggcctggtg cgcctcgacg cgggcggccc actccgggtc gtcggcggaa gggggcagcc
      241 ccggcgcgac gtagacgagg tgcgggtggc cggccacgag acgctccgca taccgcgact
      301 tcccggatcg gacaccgccg aggaccagca ctttcgcctc gtcgcgaccg taccggcgga
      361 gggtccgggc cagggcttcg agcgacctgg cgagccggtg cgtcagcttg gtcatacccg
      421 gcattctctc gtgcgcgcta ccgttcgcca cgtgccactc cgacaagccg ccaccgcagc
      481 cggcctgatc accggatatt tcgccgacac ctggttcggg gacccccgcc gggggcatcc
      541 ggtggccggg ttcggcaccg tcgcggccgc actggaacag cgctggtggg ccgactcgaa
      601 gagccgtggc gctgtgtacg ccggggcctg cgcgggtgcg gcgaccgggc tggggctggc
      661 cgcgcagatg gcgacccggc ggcgtccgct cgcccggttc gcgctgaccg cggcggcgac
      721 ctgggtggtg ctcggcgggc gcgggctggc cgccgagggc cgggaaatgg cgcggctgct
      781 cgaatcgggc gaagtgcccg ccgcacggga gcggctcggc cacctctgtg cccgcgacgc
      841 gaccggcctc gacgccgcgg agctgagccg ggcggccacg gaatcgatcg cggagaacac
      901 gtcggacgcg gtggtggcgc cgctgctgtg gggcgcggtc gccgggatcc ccgggctgct
      961 cgggtaccgc gcggtcaaca cgctcgacgc gatggtcggc taccgctcgc cgcggcaccg
     1021 gaacttcggc tggttcgccg cccgtaccga cgatctggtc aacctcgtgc cctcccgggc
     1081 cggcgcgctg ctgaccacgg ccgtggcgcc gctggcgggc ggccggtccc ggaccgcgtg
     1141 gcggacctgg cggcgggacg gatccgcgca cccgagcccg aacgccggac aggtcgaggc
     1201 tgccttcgcc ggagcgctgg gaatccgcct cggtggtacg aacagttatc acggtgagac
     1261 ggagcgtcgc ggcaccctcg gcgacggccg tccgccggga ccggcggatc tgcggagggc
     1321 ggtgcggttg tcccgcgttg tgggagcagc ggcgctcgtc gtggctgcgg caggggtgtt
     1381 cggggtgagg gcgcgatgag cgggctgctg atagcgggta ccacctccga cgcgggcaag
     1441 agcctggtca ccgcgggcat ctgccggtgg ctggcgcggc gcggggtgcg ggtggcgccg
     1501 ttcaaggcgc agaacatgtc caacaactcg atggtgtgtg ccgacggcgc ggagatcggc
     1561 cgtgcgcaat ggctgcaggc gcgggccgcg ggggtggaac ccgaggcggc gatgaacccc
     1621 gtgctgctca agccgggcag cgaccggcgt agtcacgtgg tcgcgctcgg caagccgttc
     1681 ggcacgctcg aagcgggtga gtacgcgacc ggacgggccg ggctggccga aatcgcgttc
     1741 acggcgttcg cggggctgcg tgagcggttc gacgtggtgg tgtgcgaggg cgcgggcagt
     1801 cccgcggaga tcaacctgcg gcgcggggac tacgtgaacc tcggcctggc gcggcggttc
     1861 tcgctgccgg tgctggtggt cggcgacatc gaccggggcg gggtgctggc ggccatgttc
     1921 ggcaccctcg cgctgctctc ggccgaggac caggcgttgg tcgcaggctg gctggtgaac
     1981 aagttccgcg gcgacgtcgg cctgttgcgg ccgggcctgg acagcctggc gaaggtcacc
     2041 ggacgtccgg tgctgggtgt gctgccgtgg ctggaccggg tgtggatcga ctccgaggac
     2101 gcgctcgccg cggcgggctg gcggcacgag gcggcctcgg gcgggctgcg ggtcgccgtg
     2161 gtccgcttcc cgcgcgcgtc gaacgcgacc gacgtggacg cgctggccgc cgagcccggg
     2221 gtcacggtga gcctgaccgc cgatccggac accgtggccg cggccgatct ggtggtgctg
     2281 cccggttccc gggccactgt ggacgatctg cattggctgc gtgcccgcgg tctcgcggac
     2341 gcggtcaccg cgcgggcggc ggcggggcgt ccggtgctgg gtatctgcgg tggttaccag
     2401 atgctcgccg agtccattga ggacgatgtg gaatccgggg ccgggctggt gcccgggctc
     2461 ggcttgctgc cgaccaaggt aagcttcgcc ggggagaagg tgctcggccg cccgtccggt
     2521 tcctggcggg ggcatccggt ggacgcctac gagatccacc acggcagcgc cggtcctgcc
     2581 gacgcggagt cctttctgga cggttaccgg gccggcgcgg tgtggggcac cacctggcac
     2641 ggtgcgctgg agaacgacgg tttccgccgg gcctggctga ccgaggtggc cgcgcaggcc
     2701 gggctcacct gggcgccggc tcccggcgcg cccggcttcg ccgcgctgcg ggaggacatg
     2761 ctggaccgcc tcgcggacgc gatcgagtcc ggtgtggaca ctgaacgcct gctcgacctg
     2821 gtcaccggcg gcgcacccgc gggccttccg ttcgtgcctc ccggggcgcc gtaagcccgt
     2881 ctcgaaggct gtgaaggggc ccttcacgga ctcagagccg tccgtgaagg gccccttcac
     2941 ggaaaggcag cccaagggcg cagggccagc gcgcagggcc gatgcgcggt cgccccaccc
     3001 ggcttccagg gcggcttgag gatcgccggg caggctctct gctggtgact gggctgaccg
     3061 gcgacagagg gagacgcggt gacaggacca agcgatgccc atcgtgtcgt gattaccggg
     3121 attggggtgg tcgccccggg cgaccgtggt accaagcagt tctgggagct gatcacggcg
     3181 ggccgtacgg ccacccggcc gatctcgttg ttcgacgcga gttccttccg gtcgagggtg
     3241 gccgccgagt gcaacttcga tccgatcgcc gccgggctga gccagcggca gatccggaaa
     3301 tgggaccgca ccacgcagtt ctgcgtggtg gcggcaaggg aggcggtggc cgacagcggg
     3361 atgctcgggg agcaggatcc cctgcgtacg ggggtggcga tcggcaccgc ctgcggcatg
     3421 acccagagcc tggaccgcga gtacgcggtg gtcagcgacg agggcagcag ctggctggtc
     3481 gacccggatt acggggtgcc ccagctctac gactacttcc tgccgtcctc gatggccacc
     3541 gagatcgcgt ggctggtgga ggcggaagga ccggtggggc tggtttccac cggatgcacg
     3601 tcgggggtcg acgtgatcgg gcacgccgcc gacctgatcc gcgacggcga ggccgacatc
     3661 atggtcgccg gtgcctccga ggcgccgatc tcgccgatca cggtggcctg cttcgacgcg
     3721 atcaaggcca ccacggcacg caaccacgaa cccgagtcgg cttccaggcc gttcgaccag
     3781 acccgcagcg ggttcgtgct cggcgagggc gcggccgtct tcgtgctgga ggagctgagg
     3841 cacgccaagc ggcggggcgc gcacatctac gccgaaatcg tcgggtacgc gtcccggtgc
     3901 aacgcctaca gcatgaccgg gttgcgtccg gacggccgcg agatggccga cgcgatcgac
     3961 ggggcgttga accaggccag gatcgacccg tcccggatcg gctacgtcaa cgcccacggg
     4021 tcgtcgacca ggcagaacga tcggcacgag accgcggcca tcaagaccag cctcggagcg
     4081 cacgcctatc aggtgccggt cagctcgatc aagtcgatgg tcgggcattc gctcggcgcg
     4141 atcggctcgc tggaggtcgc ggcctgcgcg ctgaccatcg agcattcggt gatcccgccg
     4201 acggcgaatc tgcacgtgcc cgacccggag tgcgacctgg actacgtgcc actggtggcg
     4261 cgggaacagg aggtcgacgt ggtgctcagc gtcgcgagcg ggttcggcgg tttccagagt
     4321 gccatcctgc tgaccggccc ggacggcaga accgggaagc gggtaacgca gcgatgagcg
     4381 tggagacaga accggcgccg gtgcccggcc gcagcacggt acggccggtg gtgaccgggt
     4441 tgggcgtgat cgcgcccaac ggtatgggca ccgaggccta ctgggcggcg acccttcgtg
     4501 gcgacagcgg actgcggcgg atcacccggt tcgacccgga cggctacccg gcccggatcg
     4561 cgggcgaggt cagcttcgac ccggccgggc ggctgcccga ccggctgttg ccgcagaccg
     4621 accacatgac ccggctcgcg ctgatcgccg cggaggaggc actcgccgac gcgggtgccg
     4681 atccgcggaa cctgcccgac tacgcgaccg gggtcatgac cgcggcctcg ggcggcggat
     4741 tcgagttcgg gcaacgggaa ctgcaggagc tgtggagcaa aggcggctcc tacgtcagcg
     4801 cgtaccagtc cttcgcctgg ttctacccgg tgaacaccgg gcagatctcg atccggcacg
     4861 ggatgcgcgg ctccagcggc acgctcgtgt ccgaacaggc cggtgggctg gacgcggtcg
     4921 ccaaggcccg caggcacgtg cgcgacggaa caccgctgat ggtgaccggc ggcatcgacg
     4981 gatcgctgtg cccgtggtcc tggctgtgca tgctgcgctc cggccggttg agcacggcga
     5041 gtgatcctca gcgcgcctat ctgcccttcg ataccgaggc ttccgggatg gtgccgggtg
     5101 agggtggcgc gttgctggtg atcgaggatc ccgccgcggc acaacggcgt ggcgtggacc
     5161 ggatctatgg gcagatcgcc ggctattgcg cgacattcga ccccggcccg ggttcacgtc
     5221 gtccgcccgg cctgcgccgg gcggtcgagc aggcgctggc cgaagcacgg ctgcatccgt
     5281 ccgaagtgga cgtggtgttc gccgacgccg ccggtctgcc cgacctcgac cgggccgaga
     5341 tcgaagtgct ggtccggatc ttcggcgcgc gggccgtccc ggtcactgca cccaagacga
     5401 tgaccggccg gctgctggcc ggtggaagct cgctggacct ggccacggcg ttgctctccc
     5461 tgcgggacaa ggtcattccg cccaccgtcc acataggaaa gttcggttac cgggacgaga
     5521 tcgacctggt tcgcgacagc ccccggcagg cgccgctgtc gactgcgctg gtgctggccc
     5581 gagggtatgg cgggttcaac tccgcgatgg tgcttcgcgg tgccacctga tccccacacg
     5641 aaaggaaggc aaccatggca gagttcacga tcgccgagct ggtgcggctg ctgcgcgaat
     5701 gcgccggaga ggaggaaggc gtggacctcg acggcgaggt cggggacctg ccgttcgacg
     5761 aactcggcta cgactccctc gcgctgttca acaccatcgg gcggatcgag cgtgagtaca
     5821 ctgtggacct ccccgaggac gtagtgtggc aggcgaccac gccgggagcg ctggtcgatc
     5881 tggtcaacag cagtcgcacg tcgcccgctg ccgccgactg aaaaggctgt gaagggcccc
     5941 ttcacggact cagagtccgt gaaggggccc ttcacggact cgtctcgccc gttcagcggg
     6001 tttctgccag ccgcttgacc agctgcagct cggccaggct gtccgcactc gacgtcttgt
     6061 gcagccggtc acgcaattca gggagctgtt cggctgccga cgggttcacc agcaccgtat
     6121 gcgcggacgt gacggcgact cccgcaggcg tctcggtcag ggtccaccgg ccgaggtgca
     6181 ggtccaccgg tgcggtcacg gtcagctgct tgtacgcgat tcccttgtcc ggcaagcaga
     6241 tgcggacgaa ccggctcggc tcgtccgcat cttgcgtgcg cacgtcgtag aactgcacgt
     6301 cgttctcgtc ctcggtgacc tcaagcgcgg tgaggcaggg cagatgtgca ggccaggacc
     6361 cgacgtctcg cagcgcgcgg tagacctgcc cgagttcgct ctcgatcacc agcgaatcct
     6421 cgaacgacca ggtcagctcc gcgagccggg tacggttctc gacccggctc ttgagggtct
     6481 ccatctgcag cttgccgtgc cggttcagtt cggtgacccc ggccgcgcga tcctccggcg
     6541 tggcggcgtg gaaggcgtgc cgggactcca ccaggcaccg gtcacccggc agcggtttga
     6601 aggtccacga cccggtcagc ccggtgatcg ggccgaccga gccctgctgc tcgatgtcca
     6661 tccgcagcgc gctcgcgtcc aggtaccggc gggaggtcca gatccggatc ctgcccagcg
     6721 ggttgaccgc ccagaactgc accagatcct cggtcggcgc tcgctccacg aactcggtgt
     6781 gcgcgatcca cgggtagagc agcggccagt tcgcgacgtc gaccagcatg gcgtaggtga
     6841 tctcggcggg cgcgtccacg acgatactgg cctgcgtctg ctcggcctcg gggtgtgaca
     6901 tgggttctcc tcgcgaatgg ggtgtgggaa agagggcgtt caccgggcgg acccggcgaa
     6961 cgccctcgta ggaaacgaaa acggcgggtt caggccttgt ctgcggtgaa taccgtgtgc
     7021 atggccttct ccgcggtgaa aatctgcggg ttgacgaaac cggcgtcggt gaacatgcgc
     7081 tcgtaggtct tggtcgagtg tgtctcgcct tcgtcggtca tcaccagcat gatctgcgag
     7141 aacaggtacg gcagcggctt gtcctccggg cgctcgccct cgacgaaggt gtgcccggtg
     7201 accgcgatcc gcccacccgg cttgagcacg tcgaacagcc tgcgcaacag gttcgtcgac
     7261 gtgtccgccg agaaatggtg cagcacattg gtgatcatca cgacgtcgta gggaccgccg
     7321 agcgggacgc tgaacatgtc gcccgggatt ccctcgaacc ggtcgctgat cccgttgcgc
     7381 tcgtagttct tcgcggtgat cggcagtacg ttcggccagt ccacgcccca gacccgggcc
     7441 ttcggctcgg ccttggccag gttgacgccg tagtagccgt ggctgcaggc cacgtcgagc
     7501 acgtcgacgc tgtcgcggtc cttggcccag ggcagcaact gctccgccat cagttcggcc
     7561 gcaccgttgt tgaaccaggt ggtgttctcc gcgaagtcct cccagtagtc gaattccggg
     7621 gtcagggcgt ggctgtccat cacggcgccg cccttgcgca ccgcctcggt gagccgcttc
     7681 tgcgcgtccc attcccagtc gctggcgccc agcttcaacg acggcccgaa gaaggtcggg
     7741 ctggagctga gcaggaactt gtcgccgtcc accggcaacg cgtacttccc gtcgaccgtg
     7801 cgcagcaacc cgatggctgc caacgagtcc agcgtgatgc gcagtcctct ggcgtccacc
     7861 ccgagcgcac gcgccaggcc gtcggcgtcg acggtacggt cgccgatgcc gtcgaagatg
     7921 ttcagctcga tcgccgtgcg cagcagtgcc gttttcacat agccgcgcat gatttcgtgc
     7981 agcttcttcg cggtcactgt ggtcggttcc gtctcggtca tgaccgtcct ctcgtcgatc
     8041 cccttgatcc cgcaagccat agtgctcagg gcggctagtg cagcaataga gcggacggcc
     8101 acggatggac ggctccacga gtccgggtcg agcctgcctc ggcaggctgg cgaaaccacc
     8161 gacccgggac aagaaggagc ggacatgcgg ctgttgctgg tcacttggaa tgcgccggct
     8221 cacctgttcg cgatggtgcc cctcggctgg gccgcgcaag tagccgggca cgaggttcgc
     8281 gtcgcggctc cgccctcctg taccgaggcg atcggccgta ccggcctgac cgccgtaccc
     8341 gtcggcacgc agcgtccggc cgcgccgtcc gggcctccgc cgggagcgcc cagcggtcgc
     8401 tggccggtcg actgggcggt gcatcccgaa ctgctcgacg acagccggca cgagcttctg
     8461 cgttcgctgg ccgcgcgcca gttcgccgcc gccgagccga tgctggacga cttgatcgag
     8521 ttcgcacgct ggtggtcgcc ggacgtcgtg gtgtacgacc cgaccagcct ggccggcgaa
     8581 gtggcggcca ccgtgctcgg cgtgcccgcc ttcgcctgtt cctggggccg cgcggcggcc
     8641 gtccggatcg agcggggtct gggctccgag ccgctgcttg gctacgcgcg gctgtttgaa
     8701 cggttcgggt gccaggcccc gcagggaccc gcctcctggt tcgacccgtt ccccgccggt
     8761 ctgtggctgg ctgaaccgga tttgccgcgg caggcgatgc gcttcgtgcc tggaaccggc
     8821 ggcgacgccg gttcgctacc cggctggctc cgggaacact cggctcggcc gaggatctgc
     8881 gtcaccagcg cggaacccgg tggtctgttg cggccggaag ccgtacgggc attctaccgg
     8941 cacgcgctca ccgtactgtc cgatgtggac gctgaggtcg tggtgcccgc gggtccggcg
     9001 gcccgcacgc tgctggccga gattccgcac accgcgcgga tcgtcgaccc ggtggccgcg
     9061 catctgctcg tcccggcctg ccggctcacc gtgcaccagg gtgacgggct gtccactttg
     9121 gccggtctga attcgggggt tccccagtac gtcctggcgc cacgtccgga gcaggagctg
     9181 gtggggcacc agctgcaccg agccggtgcg ggcggctacc ggagcctgtc cgaacccgtg
     9241 gacgttccgg ccgaacgtgc ggtgctggat gccttgctgg caccggaaag cgggggagcg
     9301 gcggcccgca agctgcagga ggaaacgctg gcactcccgc tcccgtccgc cgtgctcggc
     9361 cggatcgagt ccgccacccg ctgagcctgc gctcggcctg cgcgccgagc ccccgaccaa
     9421 ggctgtgaag ggccccttca cggactcaga gtccaatgcc aggaacttaa ggtctggtgg
     9481 gtggtgttga tcacggtttg ggtgtgatcg gcgtggtggt gtggataggc aacgaggctc
     9541 cggctagagc tggtgattgt cgagatcatc agcaagccag gagcctcgtt gtccgttcat
     9601 ggtgtcatgc cctcgggctg gtcctcgccg gtgggtcggt tgttgtcaca ggccgggctg
     9661 gggttgctgt cgtgggtcgt cccgcccgcg ctggttgatg aggcgctggc cgtcgccggc
     9721 cgggacgaac ggcggttccg ggcactgccg tcgcggttgg gcgtgtactt cgtgctcgcg
     9781 ttgtgcctgc tgcgcaccaa gtccggcaac gcgacgatca gggcgatgtt ctcgcaggag
     9841 agtctgcccc ggttgtccgt gctgggctgg tggccgccgg ccagcacggc gctgaccaag
     9901 ctgcgggacc ggatcggcgt ggtgcccttc cagttgttgt tcggcgcgct ggcgcgggcg
     9961 gcgcctaccc ggaacaggcc gtggtcgcac gcgttcgggc tggaggtgtg tgcctgggac
    10021 ggcaccgagg tcgagccggc cgacaccgcg gccaaccgtg aacacttccc gccccatcac
    10081 cgcacaggcg tggcccgcgg gccgtccaag atccgggtgc tggtgctgct gtcgtgtggc
    10141 agccgccgtc tgctcggcgc ggtcaccggc ccgctgagcc agggcgagcc caccctggcc
    10201 tatcagctgc tgccccggct gcacgaccgg atgctgctgc tggccgaccg ctgcttcctc
    10261 ggctatccac tgtggaccgc ggcgcgggaa cggggcgcgc atctgctgtg gcgggccaag
    10321 cagaacaccc cgaagctgcc cgtgcagcac gcgttgccgg acgagtcctg gctgtccacc
    10381 ctccacgccc cggccgacgc ccgccgctgg gcgcgcaacg tgcgccgcaa caagcaacgc
    10441 gggcaccgcc cgcccacgcc ccgcccgatc aacggcatcg tcgtccgggt ggtcgaagca
    10501 ctgatcaccg tcaccgtcga cggcgtcacc cgcaccgaga aataccggct ggtcaccagc
    10561 ctgctcgacc ccgcacacgc acccgccggc cagctcgtcg ccctctacgc ccgccgctgg
    10621 accgccgaaa ccggcatcaa agagatcaaa accacgctgc tggccaagcg gcccctgcgc
    10681 ggccacaccc cgatccgcgc ccagcaggaa ctctgggcca ccctgatcgt ctaccaggcc
    10741 atccggctgc tgatcagcca cgcagcgctc acccagaacc tcgacccgtc ccggatctcc
    10801 ttcacctccg cccgcgacgc cgccgaacac gcgatcacta ccacacccgc cgacacatcc
    10861 cgacacctcc aatgggtggc ccaggactta tgccgacagc tgatcaccgt ccacacccac
    10921 caccgcgtct acccccgagc actcaaacgc accaccacgc gctaccccca ccgcagcaaa
    10981 accccgcaac cgaccagcac caaagccagc taccaggtcc acatcctgcc cacagcagaa
    11041 acaacaccac ccaccacaac caaaccaaca ccacaccaac ccagaaccga cctaagttcc
    11101 tggcattgga ctcagagtcc gtgaaggggc ccttcacagc ccttcacggt tggtcgaggc
    11161 gcgccacggc ctgcccggag gccacgaaca ggccgccgcc aggagtgggg gttcccctgg
    11221 cggcggcccg gacgagatcc cccatgccgg gggacctccg catcaggcgg ccgcggcctg
    11281 cctgcgacgg ctttccacct gtacgaggag catcgacggg atgagcacga tcgcggtgca
    11341 cgcgacgatc caccagtgcg tgtagccgat cgcgtcggcc gcgccctcgt ccgtctgcgg
    11401 acctgaggcc agctggaagg ccaccagcac cgtcgtcagc gcggtcccga acgagccgcc
    11461 gacccgttgc agcacattga agatcggggt ggcgtgcggc acgtcctcct tgccgatcat
    11521 ggccagcccg gcggccatcg ccggcgtggt ggtcatcccg atcccgatgc cgcgcacgat
    11581 ctggaccagc gacagccaca cgtaactgtc gtgcggggtg accagcgcga gcgggatggt
    11641 gccgatgatg gtgacgacca ggccggcgaa gatgacccgg gcgccgccga tcttgtcggt
    11701 catcttgccc gccagcggca gcgccagcac ggtgccgatc gccgacggcg cggtcagcag
    11761 accggcggtg accagatcct cgtgccgcac ctggaggaag tagatcggca gcacgatcat
    11821 cgcgccgaac agcgcgatcc ccatgcagaa gatcacgacc gccgccgagg agaaggcccg
    11881 gtccttgaac agccgcaggt tcagcagcgg attcctcgag cgcaccgcgt gcagggtgaa
    11941 cagcgccagc agcagcgccc cggccacggc ggcgatcacc gcgatggtct cggtgcggcc
    12001 gccgttctcc ccgatcccgg ccacgccgta ggtcagcagc ggcaggccgg ccaccaggat
    12061 gatcaggccg cgcacatcca gcgcgggcgc acccttcggc ggcgccttcg gcagccagcg
    12121 caggccggcg aagaagccga gcgcgccgag cggcacggtg atccagaaca gccacggcca
    12181 gccgaggccc tgggtcagca cgctgcccag cgtggtgccc accgcgggcg ccaggtagat
    12241 cggcacgctg accgcggtca gcatccggcc gatccgcttc ggcccggccg cggtgaccag
    12301 caggatctgc ccggccggca ccagcaggcc gcccgcgatc ccctgcagga cccggaaggt
    12361 gatcagcatt tccaccgagg tcgacagcgc gcacagcgcc gagaacaggg tgaacagtgc
    12421 cacgctgccc agccacagcc gggtcgcccc gtagcgcttg gacgcccacc cgctgaccgg
    12481 gaccgcggtg gccagcgcca tcaggtaccc ggtcgccgtc cactgcaccg tgcccagcgg
    12541 ggcgctcagc ttctggctga gggtgtccag ggcgacgttg acgatggtcg aggtgaacat
    12601 ggacgtgaac ccgccgagga tcaggatcga cgccagtccc cacagcgccg ggctgatccg
    12661 gttctcgtcg gcgccgaccg tgtccggtct cgcgagattg tccttcatcg agcttccttg
    12721 cgtgagtcgt cgtggtggtg cgatccgtgt ccgcccggtg accgagcgtc gacttagcac
    12781 cgctaagtct tagcggtgct aatatggccc ccgagacacc gatacgtcaa gtcggtgcac
    12841 gcaacccgag gggatgccgt gcggctgagt cccgaaacct tcgcgcgcgc cgcgctgaag
    12901 ctgctcaaca aatccggcct ggagggggtg agcctgcgca agctcggcga cgagctgggc
    12961 gtgcaggggc ccgcgctgta cgcgcacttc aagaacaagc aggagctgct cgacctgatg
    13021 gccgagatca tgctcgacga ggcgctcgcc ccgctggacg cgatgaccga ggtggccgac
    13081 tggcactggt ggctggccga acgggccagg accatccggc gcaccctgct gtcctatcgg
    13141 gacggtgcgc tgctgcacgc gggatcccgg ccgaccgccg acggcgccga agcgatcccg
    13201 gccctgctgc ggccgttgcg agaggcgggc ttcagcgaca aggaagcact caccgtgatc
    13261 atcaccatcg gccgctacac gctggggtgt gtgatcgacg agcagcggcc gggcgagccc
    13321 gccccgcagc ccggcccggg tgccgacgac accttcgagt tcgggctcca ggcgttgctg
    13381 gccggactgc gggcccggct gccggaacgg gtacccgaca gcgccggata actgccggga
    13441 gggttcagcg gtcggtgcgc ggggtcgcct tgacgaactc ggccagcctg cgcaccccct
    13501 cgcggatctc ctcggcggtc agcgggctga agccgagccg gacgatgtgc tcgccgccgt
    13561 caccgacgta gaacatgctc atcggcgccc agcccacccc gtggtcgcgg gccgagcggt
    13621 ccagtgcttc gaggccggcg acgaagggca cctcgacgga gaggaagaac ccgccgcccg
    13681 gcacgttcca gcgcacgccg tgctcggcga accgctccgg cgggaagtgt tcggcgaggc
    13741 tgctcagcgt cacctccagg tgccgcacgt acaggtcggc cagctcccgg ttcgcggtgc
    13801 gcaggctgaa atccgcgtcc aggagcaccc cgccgaccag ggcttgcgag atgcccgagg
    13861 tgccgacggt gaacatgctc ttgaccttgc cgagttcctc ggcgagcggc ttggccgcgc
    13921 cggggccgcc ggtcacttcc tggtctgcga ccaggtagcc gacgcgtgcg ccggggaaga
    13981 cggtcttggc gaaggagccg aggtagatca ccctgcgctg ggtgtcgagt gccttgagcg
    14041 tcggcacctg cgcaccgtcc cggccgaaca gaccgtacgg attgtcctcc agcagcagca
    14101 aatcctgctc ggcggcgact tcgagcagcc ggtgccgggt ggcgatcggc agcgagtgtc
    14161 ccgaggggtt ggagaagtcc ggggtcacgt agcaggccac cgggcgcaga ccggacgcgc
    14221 gtacctcgcg ggccaccgcc gcgacctgct cgggatcgat accctcggcg ccctccggaa
    14281 ccgcggccat cgggatgtcg agcatcttcg cggctcccgc gatgccgacg tagcaaggcg
    14341 aaacggtcag caggacgtcg ctcggcgagg cgaacagccc gcgcagcgcg atcatcatcg
    14401 cttcctggca gccgtgggtc accatgaccg cctccggcgc gacgtggatg tcctcgtcca
    14461 cctccagcgt gcgcgcgatc atgtcccgga tcagcccgtt gatcggcccg tactggaaca
    14521 gcgccttctt gatccgttcc tcgggcatgc cccgctcacg cagatgctcg acgaagcggt
    14581 ccaggtagtg gtgcagcttg gcgatgtcga agaaaccttc atacggccgg ccggaggcga
    14641 acgagaccgc ctgcggatac cggaaagccg tctcgctgag caaccgcatc gagtccatcc
    14701 gcggatcgga cacccccgtg tgcaggccgg ccagttcgag cgtcacggcc gagccggtgg
    14761 tcaggtcttc ccgagccttc gtcatggtca tccagccttc tgatggggga gcggcgacgg
    14821 tggccactgt ggactgctcg cctcaagagg tggtctcgcc cggttggaac ggcgagtgcc
    14881 gggatccgac cgacaatcga gccgtgccgg ttacggtccc ggcatgacgg atatccggac
    14941 tgacttctgc gtcgtcggtg gcggaccggc cgggctgacc ctggcgctgc tgctggcccg
    15001 atccggcgta cgggtcgtcg tggtcgaacg gtcccgttcc ttcgatcggg aatatcgcgg
    15061 cgagatcctg caaccgggtg gccaggcctt gctcgccgag ctgggcgtgc tgactccggc
    15121 ccgggagcac ggagcgcacg agcatcaccg atttctcttg gaggagcacg gaaaagtcct
    15181 gatcaacggc gactaccggc ggctgcccgg cccgttcaac tgcttgctca gcatcccgca
    15241 acggcacctg ctgagggaac tgctggcgca gtgtcacgag cacgcgggct tccagtactt
    15301 gtccggcacg aaggtcaccg gtctggtcga ggacggtggc cgggttcggg gcgtggtctg
    15361 tggcgacgac caggtggtgc tcgcgcactg cgtgatcggg gccgacggac ggtattcgaa
    15421 ggtgcggcag ctcgccggga ttcccgccga ccgggtcgag ggcttccgtc aggacgtgtt
    15481 gtggttcaag ctgtccgccg acggcgagct gccgagtgag gtgcgggtgt tccgggcggg
    15541 cggcaacccg gtgctggcct acacgtcggt acgtgaccgc gtgcagttcg gctggacgtt
    15601 gccgcacaag ggttatcagc tgctggcgca gcagggcctc gcgcacatca aggagcagct
    15661 gcgggccgcc gtgcccggct acgcggaccg gatcgacgag gagatcacca gcttccggga
    15721 cctttccctg ctggacgtct tctccggggg cgcccggcag tgggtgcgcg acggtctgct
    15781 gctgatcggc gacagtgcgc acacccacgg cccgatcggc gcgcagggga tcaacctggc
    15841 catccaggat gctgtggccg cacatcccct gctgctggag tcgttgcgtg ccaacgactc
    15901 cagcggggcg atgctcggcc ggttcgtgac cgggcgcaag cgggacatcg accggatgaa
    15961 ccggatccag gccgtccagg gcaaggcgat gctgtccgcg ggccgggtct cgtcggtggt
    16021 ccggccgagg ctggcgatgg tggtcgcccg caccccgatc taccgcgcga tgttgcggca
    16081 gatcgcgttc ggcaacaccg ggatccggat ccgcgccgag ttgttcgccc gccgctgacc
    16141 ggtgatcagc ccgggatggt cgtctcgacc atgtgcaggt aggagttcac cgcgctgacc
    16201 cggtccacct gcagcccggc ctgtccgatc agcccgagca ggccgtcctt ggtgtgcttc
    16261 ttgccgccca cgttgagcag cagcaacagg tccatcgcgg tcgcgaactt catctccgga
    16321 gtgccgtcga ccaggttctc gatgatcacc acgcgggcgc cgggccgacc ggctgccacc
    16381 gcgttgcgca gcgcgaggac ggtgctctcg tcgtcccact ccaggatgtt cttgaacagg
    16441 tagacgtcgg cctgcaccgg gatctcccgg cggcagtcgc ccgccaccag ctcggcccgg
    16501 tccgccaggg ctccgcccac gcgcagccgc tcgtcggcgc ccgccaccac cgcgggcagg
    16561 tcgaacagca ccccgttcag cttttcgttg cgggacagca gggtggccag gacgttgccc
    16621 tgtccgcccg cgatgtcggc cagccgctcg gccccggtca ggtcgagccg gtcggcgatg
    16681 gccagggcgg agagcttgct ggactgggtc atggccttgt cgaagacctc ggccgactcc
    16741 ggccactgct cgtgcaggta ctcgaagaag tccttgccgt gcaagtcgtc gaagacgttc
    16801 ttgccggtgc ggacggcctg gtcgagatgg ggccacagct cccaggtcca cggctcggtg
    16861 ccccacagca ggatgtgctt gaggctgcgt ggcgcgtcct cgcgcagcag ccgggaggcg
    16921 tcggtgtgca cgaacttgtc cggctccggt tcggcgaaca cctcgaaaca ggtcagcgac
    16981 cgcatcaggc ggcgcagggc gcccgggtcc gcgtgcacgg ccttggccag ctcgtccacc
    17041 gtcgcgggct ggtcgtcgag aacgtcggcg aggccgagtt tggcggcagc gcggaccgag
    17101 gcggcgcacg ccgcgctgag cgccagctcg cggactcgca tcaccgcggc gggaagaacg
    17161 gtacctgtca tgactgctta cctttctgct gggtgggggc tgtggaggtc tgtgaagggg
    17221 cccttcacgg acttcgtggc ggtcggagct aggcgccgtg ttcggcgcgc agcacgaacg
    17281 gagcgggctc cgcggtcgcg tgcttcatgg cctcgccgac cggctcgcgg aaacccttgc
    17341 ccgcggtcgc ccgctggtgg tcctcggcgc tgtcccattc ggcgatctcg gtgaacaccg
    17401 cttcatcccg ggccgactgg tagagccggt gcgaccggaa gccgggctgc gcggtcatgt
    17461 gcgcggtgat ctggccgagc agccgccgga actcggtggc gtcgccggtg acggtgaacc
    17521 ggttgatgaa ggtgaacacg gtcttgctcc tgttctgtcg ggcgatttcc gatgcgccat
    17581 cggcatttct cgcgtggatc tgttcgcgca gcgcacggcg ttgcagcttc ccgttggggg
    17641 agcggggaat ccggtcggtc agttcgacgt ggcgcaggtg cgcgtagtac ggcagccgtt
    17701 cggcaacgaa ctcggcgagc tgcgccggat tgagcccggc gcccttgggc accaccagcc
    17761 cgtacgcgac cgatccgctg aaatcgtcgg ggtagtccag taccacgcag tcggccacct
    17821 cggggtgact cagcacgacc cgctcgatct ccgtcggcga cacgagccag ttgtcgcact
    17881 tgaagacgtc cttgatccgg tcgaccacga acagcacgcc ctcggcgtcg acgtagccga
    17941 cgtccccggt gctgaaccag ccgtcgggat cgacgtcctg gcccggctcg cggccgaggt
    18001 agccgagcat cagctgcggg ccacggacct ggatctcgcc cttttctccc accggcagta
    18061 ccgcgcggga gtccacgtcg acgatcctgc agccggtgcc cgccaccggc cgtcccgacg
    18121 agcccgtttt ggggcaggac aaggaatcga agtgcgtcga cggcgacgtc tcctgaagtc
    18181 cgtacccttg gacgaccggc accccgaaac agccggtcag cgcgcgggtc gacggcagcg
    18241 gcagcgccga gccgccgcac aggatgacct gcagtgcgtc cgccgccagc gtggacaggc
    18301 gcgggtgcac cgccagtcgg gacagtcgca tgggcaggct gtagaagtgc gtggccttct
    18361 cattgtcggc ggcgtccacg gcctgagcca cgtcgtcgcc gacgtgcagc accagcgtgg
    18421 cggcgaaggt gaccgccatc gtcaggtgca tcaggtggaa ggtcggcaga tagttgaaca
    18481 gcaccgacga cggggtgatc ccgtgcgcgt gtccggactg ggccgcgttg acggtgatgt
    18541 tgcggtggct gagccggacc gccttggctg ctcccgtggt gccgctcgtg aactgcaggc
    18601 aggccacgga attctcgtcg caagtggtgg cgggcagcac gccgtccggt gcggacgcga
    18661 ggacctcgtc cagggtcggc ggaccggacg gttcggtctg gtcgtcgcga tgggtcagca
    18721 cgaggtgccg cagctcgggc agccggtcca gcaccggcac cagcctgcga tgcacctccg
    18781 gcggcacgat cgccgtgacc gcgcccgacg tgcccagcac gtgcaccagt ccgtccgcca
    18841 gcagcagcgg gttgatcagc gcgggcaccg cccccgacct ggcgataccg aagaacgaca
    18901 cggcgaacgc cgggtcgagt acccccgcca gcgccaccac ttgccccggt tcggccagct
    18961 gcgcgtggac ggcccgcgcc agtctgccgg ctcgctcatc gagcgccgcg tagctcagtt
    19021 cgcaggctgc cgcacgaatc gccacgtgct cgggcgcgcg ttcggcggcc gaacgcagca
    19081 ggtcgtcgac cctggggccg ccgatgaacc ccgcgatccc ggtcaacggg tcgccggaca
    19141 ccgtgctgtc ctgggcgacg gtcgtctcgg gcgtagccat gtatccctcc tccgctggtt
    19201 gggtttcagt tcctcggcag gtcgtcgcgg tacacctggc gctcgcgcac caggagcgcg
    19261 ccgccctcgc gcaccagcac gtccacgcag tcacagctga ggtcgaccgc agccttgcca
    19321 cccagcggcg taccgatgat caccgcgtag ctcttggcca cgatgctgcc gtcgggctgc
    19381 ggatcgacct gcaccatgcc cagccagtgc cgccgctgga tgccctgttc cgccaggcgg
    19441 gtggccgctt cgagcgcgcc ggcctcgatg gccgtccggc cgcgggcggg ttcggggtgc
    19501 gcgttggcgg cgaacatccc gtcctcggtg aaggtcttgg cccactcctg cacgcggccc
    19561 tcgtccaggt agcgcatctg gcgcccgtag aactgctgga cctccacgta cagcgcgatg
    19621 tcctcggtgc tgccgactgc ctgtaccgcc tgtgacatga ctgctccctc gcttgctcgt
    19681 ggtcggcaaa cgatggcacc ggggcatcgg acgccactca actgaggacg accggcaccg
    19741 gctcgaaccg ggcgctgatc ggacttgagc cgccgggtac agcctggtcc cgttcacaac
    19801 ggacgggctg gagggaaggc tgatgaggag caccgaggag ccgcgggtcg ccttggtcac
    19861 gggagcgacc agcgggatcg gtctcgccgt caccaaggcg ctggccgcca ggggactgcg
    19921 ggtgttcatc tgcgcgcgca accgggagaa cgtcgtttcc acggtgaagg agttgcgggc
    19981 gcagggtttg gacgtggacg gccaggccgg tgacgtgcgg tcggtggccg ccgttcgcga
    20041 ggtggtcgag tccgcggtca accggttcgg caccatcagc gtgctggtca acaacgccgg
    20101 ccgcagcggg ggcgggatca ccgcgaagat caccgacgag ctgtggcagg acgtgatcga
    20161 caccaatctc aacagcgtct tcacggtcac ccgcgaggtg ctgaccaccg gcgggctcga
    20221 cggggccgac ggcggccgga tcatcaacat cgcctcgacc gggggcaagc agggcgtccc
    20281 gctcggcgcg ccctactcgg cggccaagag cggggtcatc ggcttcacca aggcgctggg
    20341 caaggaactg gccaagaccg gggtcacggt gaacgccgtc tgccccggct acgtcgaaac
    20401 gccgatggcc gtccgcgtcc ggcaggcgta tgccagcact tgggacacca ccgacgaaaa
    20461 cgtgctggcg cggttcaacg acaagatccc gctcggccgc tactgcactc cggaagaggt
    20521 ggcgggcatg gtcgactacc tggtcgccga cacggccgct tcggtgacgg cgcaggcgat
    20581 caacgtctgc ggcggcctcg gcaactactg accccgcacg ctcacggaaa ggcacagcca
    20641 tgcccgccgc agcacagcag cacaccgaac accggatcga catcgacgct cccgccggcc
    20701 tggtgtaccg catcatcgcg gacgcgaccg agtggccgcg gcacttcacc ccgaccgtcc
    20761 acgttgatca gtccgaactg gacggacaca ccgaacgcct gcacatctgg gccaacgcca
    20821 acgggcagct gaagagctgg acctcgctcc gggaactcga cgagcgggcc ggccggatcc
    20881 ggttccggca ggaggtgtcc gcgcccccgg tcgcctcgat gagcggcgag tggatcgtgt
    20941 ccgagcgggt cgcggagcgc accacgctgg tgctgacgca cgacttcgcc gcggtggacg
    21001 acgatcccgc cggagtggaa tggatcacca aggccaccaa cgggaacagt gacaccgaac
    21061 tggcgaacat caaggcactg gccgagcgct gggagcggat ggaccggctg gccttcgact
    21121 tcgaggactc cgtgctggta cgggcgccca aggaacgggc gtaccacttc ctggaccgcg
    21181 tggacctgtg gccggaccgg ctgccccacg tcgccaggct ggagctgcgc gaggacgtgc
    21241 ccggagttca gcacatgtcc atggacacca aggcgaagga cggatcgacg cacaccacgg
    21301 tgtcggtgcg ggtgtgcttc cccgaagccc ggatcgtcta caagcaactc gtgccgcccg
    21361 cgttgctgac cacccacacc ggagtgtgga cgttcgagga cacagcggac ggtgttttgg
    21421 tgacttccgc gcacacggtc gtgctcaacg aggccaacat cggcacggtg cccggcccgg
    21481 ccgcgactgt cgagtcgacg cgcgacttcg tccgcaacgc gatcagcggc aacagccagg
    21541 ccacgctgcg tcatgccaag gcgttcgccg aggcgaccga tgcctgagga ctccggcgaa
    21601 gagcccgaag tcctcgtggc cggggcgggg ccggtcgggc tgaccgccgc gcacgagctg
    21661 gcccgccgag gggtgcgggt acggctggtg gaccgtagcg ccggcccggc cacgacgagt
    21721 cgtgcgctcg cgacgcacgc ccgcacgttg gagatctggc accagatggg gctgctcggc
    21781 gagctgctgc cgcggggccg gcgggtcgag cacttcacac tgcatctgaa gggtaaaacc
    21841 ctgatgtgct tcgacaccaa ctatgacacc atgccgaccc ggttcccgtt cagcctcatg
    21901 gtggaccagg tcgtgaccga ggaagtgctg cgccggcagg tgcgggcact cggggtcacg
    21961 gtcgagtggg gcgtcgagct gacctggttc gaccaggagc cggacggggt cctggcggag
    22021 ctgcggcatg cggacgggac agtcgagcag gtcaccgcgg cctggctggt cggcgcggac
    22081 ggtgcccgca gcaccgtccg caagcggttg gacctgcgcc tgcaggggga ctccacacag
    22141 acctggctca acgccgacgt ggtgctcgac acggatctgg ccggcgacag caaccacctg
    22201 ctgcacaccg gacgcggcac cttgctgctg gttccctttc cagaaccggg aaagtggcgg
    22261 gtggtcgaca ccgaggacac cgaccacgcc gacgatgccc ggatcgtccg ggccaggctg
    22321 gccgacaagc tcaccagggc gctcggccgc cccatcgagg tgcccgagcc gagctggatc
    22381 tcggttttca ccgtgcagca gcggatgatc gaccggatgc gggccggccg ttgtttcgtc
    22441 gccggtgacg ccgcccatgt gcacagcccg gcgtccgggc agggcatgaa caccgggatc
    22501 caggacgcct acaacctggc gtggaagctg gcggacgtgg tgcgcggcca cgccaaggag
    22561 agcctgctcg acagctatgg ggccgagcgg gtgccgatcg gcgagacgtt gttgcgtacc
    22621 accaggaccg ccactgcgct tgtgagcctg cgcaacaccg tcgcgccgtt ggtcatgccg
    22681 gccggaaccc ggctgctggg ggcgctcaag ccactcaaac ggcggatcga gcgcaccatg
    22741 atccggggct tctgcgggct gaccctgaac tacacccaca gcccgctgag cctggcctgc
    22801 gcaaccccgg acggcatcca gccgggacat cgggtgggct gctcggtgga tcgtgcccgg
    22861 acctcaccgg gatggcaagg gctggtcacg gaactgaccg atccccggtg gactttgctc
    22921 gccttcgccg attcccagga acagcggcag atcgccgcgc aagtcgagcg gcgctacggc
    22981 aaggccgtct cggtgcgggt ggtggccgag gccgccacga gcgagcgggt tcttgccgac
    23041 ccgggcgatg acctagcacg agatttcgcc atgcgggcag ggtatttcgt gctgatccgg
    23101 ccggacggcc acctggcggc gaaagggcgg ctgagcgatg acctggatgg cgcattcggc
    23161 gctctgggac tcgtgccggc cgatgccggg ggagacccgg cccaccacct cgattccgaa
    23221 ggatcacgca tgcgcatcat cgacctgtcc gcgaccatgg acgctgccga tcgctgggag
    23281 gccaacccgg tcacccacga ggtgctcacg gccgccgaag gcgcgcagca catggcggcg
    23341 gagatgaaag agcacttcgg gatcgacttc gacccctcgg tgctgcccgg cggggagttg
    23401 ctcacgctgg acacgttgac gctgaccacg cacaccggca cgcacgtcga cgccccgtcg
    23461 cactacggga ctccccgcga cggcgtggcc aggcacatcg accagatgcc gctggagtgg
    23521 ttcctgcggc cgggggtggt cctcgacctc acgggcgagc cggtcggcgc ggccggtgcg
    23581 gaccggctgc gcgaggagtt cgagcgaatc ggctataccc cgaagccgct ggacatcgtg
    23641 ctgctcaaca ccggcgccga cgcgctggcc ggaagcccga agtacttcac cgacttcacc
    23701 gggctcgacg ggaaggccac cgagctgctg ctcgatttgg gggtacgggt catcggtacc
    23761 gacgcgttca gcctggacgc gccgttcggt cacatgatcg ccgaataccg gcgtacgggg
    23821 gatcgctccg tgctgtggcc cgcgcatttc gcgggccggg accgggagta ctgtcagatc
    23881 gaggggttga ccaacctggc cgcgctgccg tcgccgaccg gtttttcggt atcctgcctg
    23941 ccggtcaaga tcgccggcgc gggcgccggc tggacccggg ccgttgccct gctggactag
    24001 gaaggaaggt ccgtgaaggg gcccttcacg gactcagagt ccgtgaaggg ccccttcaca
    24061 gccgcggtga ccgatgtatc gggagataca tgccggcgtc gggcgatgcc cttccttgga
    24121 tgtactcctc ttgagcggcc ctcggctggg ggagtaccaa taccgtatga aattcaacct
    24181 gcttggtccg atggaagttc tgtgcgccga tggcacggtg acgcccagcg ccgcgaaaat
    24241 gcgctggatt ctggcattgc tcctgttgca cggaaatcga gtggtcgatc aggcttcgat
    24301 gatcgacgaa ttgtggggag atcacccgcc gcgcagtgcg gtgaccacca cgcagaccta
    24361 cgtttaccaa ttgcgcaaga agtacgacta ctacgcacaa cgagagggga gaaagagttt
    24421 catcgtcacc cgggcgcccg gttatctgct gcagctggac gacgatcagc tcgatgtccg
    24481 aagattccag agactcagcg ccgagggcag cgccctgttc tcggcgggcc acgccgaacg
    24541 ggcggacgag gtgctgcggc aggcactgcg gctgtggcgg ggccccgcgc tggccggcat
    24601 cgcacccggc cgcatgctgc aggcgcacgt cgcctacctg gaagaggccc ggctgcgcac
    24661 cgtgcaggtg cgcatcctcg ccgacgcggc actcgggcgg caccgggatc tgattccgga
    24721 gctgcggtca ctggtgatcg agcatccgct cgacgaatgg tttcaccagc agctgatcac
    24781 ggcactggcc gaggcagggc gcaggggaga cgccctgcac gcctgccggg tcctgcaccg
    24841 caccctcgcc gacgaactcg gcgtggcgcc ctccgagccg ctgcgcaagc tccagcagga
    24901 cctgctgacc ggccacgtcc ggcgggcacc cgcgcatgtg tgacctgcgg tggagccgga
    24961 gacggcggcc gccgccgtct ccggcctcac gcggggacca gcggcgccgc ggtctgcgcc
    25021 ttgttcaccg cgtccagccg ggaaaccgcg ttcagcttca cgaagatgtt gcgcaggtgg
    25081 cgtttcaccg tcccctgggt gatggccagg caattcccga tctgtgcgtt ggtcatcccg
    25141 cgggcgacca gcgacatgat ctcgtgctcg cgcctggaca gcggagtacg caggttcgag
    25201 gacagcgacc ggacgtcgac actcggcacc gagaggaaga cgcagcgctc gtcgcggctc
    25261 acctcgcgca ccaccgagag caggtacatg tcggagacat tcttgggcag gtaaccccgg
    25321 acgccgatgc ccaggaattc ctgaatgaaa ccgaatctgt tctcctggct caggatgacg
    25381 acgggcttcc ccggagccgc cgccgacaat tcgagcaggc cggattcgac ttccggaccc
    25441 cagccgtcga ctccatagag aatgacgtcc acaattcccc tggagacact gtcgagtgct
    25501 tcgccgatgg tcgccaccgc gtcaatggcg gccagatcgt cggcgccttg aatcagcgaa
    25561 agcagcccga cgcgaaaaac ggaactctct tcgacgatca gaattcttac acggtcagtt
    25621 atcatggtgt gataacactc ccccggtatg gtcaaccgtg ccagcccgcg cggctggcgg
    25681 ttccttcgta tagtcccccg actgcgtggc ataaaaattg gcggaagcgg cacgaggctc
    25741 gcttccggca atgacgtgca caaaagtgtc tgccaagacc tgtctgtcgc ggcctgctca
    25801 gacggacagc actcctcggc tgtcgcggcc gagccggctt gtcaagctca tgaaagtcac
    25861 ctgcttcccc cacggaatgc gtagcaccaa cgtacggcca gcctgttgaa acgtcaaggc
    25921 atatcggctg ggtacgggat ccggtggaga ccttcccatg cccgccggtc gccgaagtag
    25981 ttgagcactc acatttgcgg ttccgtggtt ccgggaatat ctccacaatg gacgaattcg
    26041 gccggaatcc gatggtcagg aggtcgccgg gagcgcttcc ggatttcccc gggtcggacg
    26101 a
//
