BGC0000208 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000208 (Amycolatopsis sulphurea)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	26,101	High	chelocardin	PKS

BGC0000208 - Region 1 - T2PKS

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Location: 1 - 26,101 nt. (total: 26,101 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 26,102
Label		BGC0000208

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

chdOI: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

chdOII-chdY: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

chdT: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase glycosyltransferase methyltransferase

chdGIV: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

chdMI: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

chdMII: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

chdN: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: cyclase

chdQI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

chdQII: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: ligase synthase

chdK: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

chdL-chdOIII: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

chdP: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000208.5	0.99	PKS	chelocardin	Amycolatopsis sulphurea
BGC0000231.5	0.72	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.60	PKS	oviedomycin	Streptomyces antibioticus
BGC0000254.5	0.54	PKS	oxytetracycline	Streptomyces rimosus
BGC0002477.3	0.52	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000275.4	0.52	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0002047.2	0.51	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000208.5	0.99	PKS	chelocardin	Amycolatopsis sulphurea
BGC0000231.5	0.72	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.60	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.60	PKS	oviedomycin	Streptomyces antibioticus
BGC0000254.5	0.54	PKS	oxytetracycline	Streptomyces rimosus
BGC0002477.3	0.52	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000275.4	0.52	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0002047.2	0.51	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 26101:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal)
Non-colinear ordering:: chdK + chdS

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

chdL-chdOIII: X

AMP-binding (35..435): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFMYLGGPSK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 26101
Starter unit(s):: malonamyl-CoA (Score: 654.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 690.7; E-value: 1.2e-210)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 586 Da
malonamyl-CoA_9: 628 Da

chdGIV: GT (Score: 324.7; E-value: 2.5e-99)
chdK: CLF 8|9 (Score: 690.7; E-value: 1.2e-210)
chdL-chdOIII: LIG (Score: 671.6; E-value: 1.4e-204); LIG ELQ83297.1_Oxytetracycline_malonamyl-CoA (Score: 654.0; E-value: 0.0)
chdMI: MET C6|C8 (Score: 582.3; E-value: 5.8e-178)
chdMII: MET C10 (Score: 648.4; E-value: 4.6e-198)
chdN: AMIN (Score: 567.2; E-value: 3.1e-173)
chdOI: OXY (Score: 217.7; E-value: 7.4e-67)
chdOII-chdY: OXY (Score: 428.8; E-value: 6.9e-131); CYC C5-C14/C3-C16 (Score: 417.0; E-value: 6.3e-128)
chdP: KS (Score: 751.1; E-value: 6.7e-229)
chdQI: CYC C7-C12 (Score: 285.5; E-value: 9.4e-88)
chdQII: CYC C7-C12 (Score: 450.1; E-value: 7.2e-138)
chdS: ACP (Score: 117.4; E-value: 4.8e-37)
chdT: KR C9 (Score: 463.0; E-value: 5.8e-142)
chdX: CYC C1-C18|C2-C19 (Score: 228.0; E-value: 7.7e-71)