BGC0000209 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000209 (Kitasatospora aureofaciens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	41,528	chlortetracycline	PKS	100%

BGC0000209 - Region 1 - T2PKS

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Location: 1 - 41,528 nt. (total: 41,528 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,529
Label		BGC0000209

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000209	1.00	Polyketide	chlortetracycline	Kitasatospora aureofaciens
BGC0000885	0.34	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000894	0.33	Other	citrinin	Monascus aurantiacus
BGC0000234	0.32	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231	0.31	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000846	0.28	Other	tabtoxin	Pseudomonas syringae
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0000937	0.27	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000837	0.26	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000836	0.26	Other	APE Ec	Escherichia coli CFT073

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000209	1.00	Polyketide	chlortetracycline	Kitasatospora aureofaciens
BGC0000885	0.67	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000894	0.66	Other	citrinin	Monascus aurantiacus
BGC0000234	0.66	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231	0.65	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000846	0.62	Other	tabtoxin	Pseudomonas syringae
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000937	0.60	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000837	0.60	Other	APE Vf	Aliivibrio fischeri ES114
BGC0000836	0.59	Other	APE Ec	Escherichia coli CFT073

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

ctcI

AMP-binding (30..420): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: SFMYLGGPSK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 41528
Starter unit(s):: malonamyl-CoA (Score: 2237.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 672.5; E-value: 4e-205)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 473 Da
malonamyl-CoA_9: 515 Da

ctcD: CYC C5-C14/C3-C16 (Score: 435.9; E-value: 1.1e-133)
ctcE: OXY (Score: 433.8; E-value: 2e-132)
ctcF: CYC C7-C12 (Score: 439.0; E-value: 1.8e-134)
ctcG: KR C9 (Score: 445.3; E-value: 1.5e-136)
ctcH: CYC C1-C18|C2-C19 (Score: 230.8; E-value: 1.1e-71)
ctcI: LIG (Score: 764.1; E-value: 1.3e-232); LIG AEI98652.1_Chlortetracycline_malonamyl-CoA (Score: 1024.0; E-value: 0.0)
ctcK: MET C6|C8 (Score: 584.7; E-value: 1e-178)
ctcL: AMIN (Score: 618.7; E-value: 7e-189)
ctcN: OXY (Score: 475.7; E-value: 4.1e-145)
ctcO: MET C2O|C2N (Score: 608.8; E-value: 5.6e-186)
ctcP: HAL (Score: 740.5; E-value: 1.6e-225)
ctcT: AMID (Score: 1192.5; E-value: 0.0); AMID AEI98663.1_Chlortetracycline_malonamyl-CoA (Score: 1213.0; E-value: 0.0)
ctcU: ACP (Score: 110.7; E-value: 6e-35)
ctcV: CLF 8|9 (Score: 672.5; E-value: 4e-205)
ctcW: KS (Score: 745.5; E-value: 3.5e-227)
ctcX: OXY (Score: 208.2; E-value: 5.4e-64)