BGC0000210: chromomycin A3 biosynthetic gene cluster from Streptomyces griseus subsp. griseus
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Location: 1 - 42,074 nt. (total: 42,074 nt).
This entry is originally from NCBI GenBank AJ578458.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000210
Short description chromomycin A3 biosynthetic gene cluster from Streptomyces griseus subsp. griseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (oligosaccharide)
Loci
AJ578458.1
via Knock-out studies, Enzymatic assays
Compounds
  • chromomycin A3
Species Streptomyces griseus subsp. griseus [taxonomy]
References
Chemical products information
chromomycin A3 Evidence:
Copy SMILES
C57H82O26
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE17518.1
  • cmmY
 8 - 784 (-) cyclase
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    • CAE17519.1
    • cmmTI
    		 825 - 1583 (-) ketoreductase
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      • CAE17520.1
      • cmmS
      		 1585 - 1836 (-) acyl carrier protein
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        • CAE17521.1
        • cmmV
        		 2050 - 3432 (+) NDP-2,3-dehydratase
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          • CAE17522.1
          • cmmW
          		 3417 - 4427 (+) NDP-3-ketoreductase
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            • CAE17523.1
            • cmmUII
            		 4438 - 5193 (+) NDP-4-ketoreductase
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              • CAE17524.1
              • cmmOI
              		 6855 - 8102 (+) oxygenase
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                • CAE17525.1
                • cmmX
                		 8182 - 8610 (+) cyclase
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                  • CAE17526.1
                  • cmmK
                  		 8691 - 9959 (-) ketosynthase
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                    • CAE17527.1
                    • cmmP
                    		 9956 - 11224 (-) ketosynthase
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                      • CAE17528.1
                      • cmmE
                      		 11221 - 12201 (-) NDP-4,6-dehydratase
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                        • CAE17529.1
                        • cmmD
                        		 12198 - 13265 (-) NDP-glucose synthase
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                          • CAE17530.1
                          • cmmMIII
                          		 13459 - 14211 (+) sugar O-methyltransferase
                          • Tailoring
                          • Knock-out Other in vivo study
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                          • CAE17531.1
                          • cmmRI
                          		 14323 - 15225 (-) transcriptional regulator
                          • Regulation
                          • Knock-out Other in vivo study
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                          • CAE17532.1
                          • cmmMII
                          		 15688 - 16716 (+) C-methyltransferase
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                            • CAE17533.1
                            • cmmUI
                            		 16725 - 17474 (+) NDP-4-ketoreductase
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                              • CAE17534.1
                              • cmmMI
                              		 17530 - 18603 (+) O-methyltransferase
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                                • CAE17535.1
                                • cmmGI
                                		 18623 - 19804 (+) glycosyltransferase
                                • Tailoring
                                • Knock-out
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                                • CAE17536.1
                                • cmmOIV
                                		 19818 - 21338 (+) oxygenase
                                • Tailoring
                                • Knock-out Activity assay
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                                • CAE17537.1
                                • cmmWI
                                		 21346 - 22329 (+) side-chain ketoreductase
                                • Tailoring
                                • Knock-out
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                                • CAE17538.1
                                • cmmLI
                                		 22349 - 23590 (+) acyl CoA ligase
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                                  • CAE17539.1
                                  • cmrB
                                  		 23643 - 24395 (-) membrane protein
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                                    • CAE17540.1
                                    • cmrA
                                    		 24410 - 25387 (-) ATP-binding protein
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                                      • CAE17541.1
                                      • cmmRII
                                      		 25390 - 25986 (-) transcriptional regulator
                                      • Regulation
                                      • Knock-out Other in vivo study
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                                      • CAE17542.1
                                      • cmrX
                                      		 26082 - 28562 (+) UV-repair protein
                                      • Resistance/immunity
                                      • Knock-out Other in vivo study
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                                      • CAE17543.1
                                      • cmmC
                                      		 28766 - 29992 (+) NDP-C-methyltransferase
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                                        • CAE17544.1
                                        • cmmUIII
                                        		 29965 - 31035 (-) NDP-4-ketoreductase
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                                          • CAE17545.1
                                          • cmmGIII
                                          		 31041 - 32234 (-) glycosyltransferase
                                          • Tailoring
                                          • Knock-out
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                                          • CAE17546.1
                                          • cmmA
                                          		 32240 - 33508 (-) acetyltransferase
                                          • Tailoring
                                          • Knock-out Activity assay
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                                          • CAE17547.1
                                          • cmmGIV
                                          		 33505 - 34770 (-) glycosyltransferase
                                          • Tailoring
                                          • Knock-out
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                                          • CAE17548.1
                                          • cmmGII
                                          		 34919 - 36109 (+) glycosyltransferase
                                          • Tailoring
                                          • Knock-out
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                                          • CAE17549.1
                                          • cmmF
                                          		 36097 - 36726 (+) NDP-5-epimerase
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                                            • CAE17550.1
                                            • cmmOII
                                            		 36762 - 38435 (+) oxygenase
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                                              • CAE17551.1
                                              • cmmTII
                                              		 38437 - 39198 (+) ketoreductase
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                                                • CAE17552.1
                                                • cmmQ
                                                		 39332 - 40288 (+) aromatase
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                                                  • CAE17553.1
                                                  • cmmLII
                                                  		 40362 - 41948 (+) acyl CoA ligase
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                                                    Biosynthesis information
                                                    Annotation changelog

                                                    Entry version: 4

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-10-07
                                                    Update chemical activity to schema version 2.11
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 3

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2022-09-15
                                                    Removed duplicate gene annotation
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2022-09-15
                                                    Updated bioactivity data
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 2

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2019-10-16
                                                    Migrated from v1.4
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    2019-10-16
                                                    Updated compound(s) information (NPAtlas curation)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                    Entry version: 1

                                                    Date
                                                    Changes
                                                    Submitters
                                                    Reviewers
                                                    2015-06-12
                                                    Submitted
                                                    • (ID: QGSJT55NWIBPAZQIATLZ7G55)
                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                    Detailed domain annotation
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