BGC0000210 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000210 (Streptomyces griseus subsp. griseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,oligosaccharide	1	42,074	chromomycin A3	PKS:Type II+saccharide:oligosaccharide	100%

BGC0000210 - Region 1 - T2PKS,oligosaccharide

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Location: 1 - 42,074 nt. (total: 42,074 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
oligosaccharide: (minimum(3, [DUF1205, Glyco_transf_28, Glycos_transf_1, Glycos_transf_2, MGT]) and minscore(MGT, 150))

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core biosynthetic genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,075
Label		BGC0000210

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000210	1.83	Polyketide, Saccharide	chromomycin A3	Streptomyces griseus subsp. griseus
BGC0001137	0.70	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000231	0.63	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000894	0.62	Other	citrinin	Monascus aurantiacus
BGC0000278	0.59	Polyketide	urdamycin	Streptomyces fradiae
BGC0000234	0.54	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001925	0.52	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000769	0.51	Saccharide	glycopeptidolipid	Mycobacterium avium subsp. hominissuis A5
BGC0000707	0.51	Saccharide	kasugamycin	Streptomyces kasugaensis
BGC0000803	0.49	Saccharide	GG exopolysaccharide	Lactobacillus rhamnosus GG

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000210	1.00	Polyketide, Saccharide	chromomycin A3	Streptomyces griseus subsp. griseus
BGC0001137	0.68	Alkaloid	marinacarboline A, marinacarboline B, marinacarboline C, marinacarboline D	Marinactinospora thermotolerans
BGC0000231	0.67	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001928	0.66	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000894	0.65	Other	citrinin	Monascus aurantiacus
BGC0000278	0.62	Polyketide	urdamycin	Streptomyces fradiae
BGC0000234	0.62	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001925	0.62	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0000769	0.59	Saccharide	glycopeptidolipid	Mycobacterium avium subsp. hominissuis A5
BGC0000707	0.59	Saccharide	kasugamycin	Streptomyces kasugaensis

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

cmmLI

AMP-binding (21..413): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GGYPGNAIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

cmmLII

AMP-binding (17..407): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: PMNYFGGPLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 42074
Starter unit(s):: malonamyl-CoA (Score: 474.0; E-value: 2.24e-165)
Malonyl elongations:: 8|9 (Score: 668.6; E-value: 6.3e-204)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 1161 Da
malonamyl-CoA_9: 1203 Da

cmmGI: GT (Score: 411.1; E-value: 1.5e-125)
cmmGII: GT (Score: 412.9; E-value: 3.9e-126)
cmmGIII: GT (Score: 406.4; E-value: 3.9e-124)
cmmGIV: GT (Score: 425.1; E-value: 7.8e-130)
cmmK: CLF 8|9 (Score: 668.6; E-value: 6.3e-204)
cmmLII: LIG (Score: 597.8; E-value: 3.2e-182); LIG ELQ83297.1_Oxytetracycline_malonamyl-CoA (Score: 474.0; E-value: 2.24e-165)
cmmMI: MET C2O|C2N (Score: 607.3; E-value: 1.6e-185)
cmmMII: MET C10 (Score: 638.6; E-value: 4.3e-195)
cmmOI: OXY (Score: 192.6; E-value: 3e-59)
cmmOII: OXY (Score: 434.2; E-value: 1.5e-132)
cmmOIV: OXY (Score: 519.1; E-value: 2.7e-158)
cmmP: KS (Score: 780.1; E-value: 1.1e-237)
cmmQ: CYC C7-C12 (Score: 395.0; E-value: 4.3e-121)
cmmS: ACP (Score: 117.1; E-value: 6e-37)
cmmTI: KR (Score: 142.8; E-value: 3.5e-44)
cmmTII: KR (Score: 201.3; E-value: 4.9e-62)
cmmX: CYC C1-C18|C2-C19 (Score: 219.0; E-value: 4.6e-68)
cmmY: CYC C5-C14/C3-C16 (Score: 444.6; E-value: 2.4e-136)