BGC0000210: chromomycin A3 biosynthetic gene cluster from Streptomyces griseus subsp. griseus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 42,074 nt. (total: 42,074 nt).
This entry is originally from NCBI GenBank AJ578458.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000210
Short description chromomycin A3 biosynthetic gene cluster from Streptomyces griseus subsp. griseus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Saccharide (oligosaccharide)
Loci NCBI GenBank: AJ578458.1
Compounds
  • chromomycin A3
Species Streptomyces griseus subsp. griseus [taxonomy]
References
Chemical products information
chromomycin A3 [synonyms: toyomycin, toyomicin, aburamycin b]
Copy SMILES
C57H82O26
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE17518.1
  • cmmY
 8 - 784 (-) cyclase
copy AA seq
copy Nt seq
  • CAE17519.1
  • cmmTI
 825 - 1583 (-) ketoreductase
copy AA seq
copy Nt seq
  • CAE17520.1
  • cmmS
 1585 - 1836 (-) acyl carrier protein
copy AA seq
copy Nt seq
  • CAE17521.1
  • cmmV
 2050 - 3432 (+) NDP-2,3-dehydratase
copy AA seq
copy Nt seq
  • CAE17522.1
  • cmmW
 3417 - 4427 (+) NDP-3-ketoreductase
copy AA seq
copy Nt seq
  • CAE17523.1
  • cmmUII
 4438 - 5193 (+) NDP-4-ketoreductase
copy AA seq
copy Nt seq
  • CAE17524.1
  • cmmOI
 6855 - 8102 (+) oxygenase
copy AA seq
copy Nt seq
  • CAE17525.1
  • cmmX
 8182 - 8610 (+) cyclase
copy AA seq
copy Nt seq
  • CAE17526.1
  • cmmK
 8691 - 9959 (-) ketosynthase
copy AA seq
copy Nt seq
  • CAE17527.1
  • cmmP
 9956 - 11224 (-) ketosynthase
copy AA seq
copy Nt seq
  • CAE17528.1
  • cmmE
 11221 - 12201 (-) NDP-4,6-dehydratase
copy AA seq
copy Nt seq
  • CAE17529.1
  • cmmD
 12198 - 13265 (-) NDP-glucose synthase
copy AA seq
copy Nt seq
  • CAE17530.1
  • cmmMIII
 13459 - 14211 (+) sugar O-methyltransferase
  • Tailoring (Methylation)
Knock-out
Other in vivo study
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17531.1
  • cmmRI
 14323 - 15225 (-) transcriptional regulator
  • Regulation
Knock-out
Other in vivo study
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17532.1
  • cmmMII
 15688 - 16716 (+) C-methyltransferase
copy AA seq
copy Nt seq
  • CAE17533.1
  • cmmUI
 16725 - 17474 (+) NDP-4-ketoreductase
copy AA seq
copy Nt seq
  • CAE17534.1
  • cmmMI
 17530 - 18603 (+) O-methyltransferase
copy AA seq
copy Nt seq
  • CAE17535.1
  • cmmGI
 18623 - 19804 (+) glycosyltransferase
  • Tailoring (Glycosylation)
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17536.1
  • cmmOIV
 19818 - 21338 (+) oxygenase
  • Tailoring (Hydroxylation)
Activity assay
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17537.1
  • cmmWI
 21346 - 22329 (+) side-chain ketoreductase
  • Tailoring (Reduction)
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17538.1
  • cmmLI
 22349 - 23590 (+) acyl CoA ligase
copy AA seq
copy Nt seq
  • CAE17539.1
  • cmrB
 23643 - 24395 (-) membrane protein
copy AA seq
copy Nt seq
  • CAE17540.1
  • cmrA
 24410 - 25387 (-) ATP-binding protein
copy AA seq
copy Nt seq
  • CAE17541.1
  • cmmRII
 25390 - 25986 (-) transcriptional regulator
  • Regulation
Knock-out
Other in vivo study
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17542.1
  • cmrX
 26082 - 28562 (+) UV-repair protein
  • Resistance/immunity
Knock-out
Other in vivo study
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17543.1
  • cmmC
 28766 - 29992 (+) NDP-C-methyltransferase
copy AA seq
copy Nt seq
  • CAE17544.1
  • cmmUIII
 29965 - 31035 (-) NDP-4-ketoreductase
copy AA seq
copy Nt seq
  • CAE17545.1
  • cmmGIII
 31041 - 32234 (-) glycosyltransferase
  • Tailoring (Glycosylation)
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17546.1
  • cmmA
 32240 - 33508 (-) acetyltransferase
  • Tailoring (Acylation)
Activity assay
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17547.1
  • cmmGIV
 33505 - 34770 (-) glycosyltransferase
  • Tailoring (Glycosylation)
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17548.1
  • cmmGII
 34919 - 36109 (+) glycosyltransferase
  • Tailoring (Glycosylation)
Knock-out
Sequence-based prediction
copy AA seq
copy Nt seq
  • CAE17549.1
  • cmmF
 36097 - 36726 (+) NDP-5-epimerase
copy AA seq
copy Nt seq
  • CAE17550.1
  • cmmOII
 36762 - 38435 (+) oxygenase
copy AA seq
copy Nt seq
  • CAE17551.1
  • cmmTII
 38437 - 39198 (+) ketoreductase
copy AA seq
copy Nt seq
  • CAE17552.1
  • cmmQ
 39332 - 40288 (+) aromatase
copy AA seq
copy Nt seq
  • CAE17553.1
  • cmmLII
 40362 - 41948 (+) acyl CoA ligase
copy AA seq
copy Nt seq
Polyketide-specific information
Subclass Other
Starter unit Malonyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
cmmQ
+
cmmK
+
cmmY
+
cmmS
+
cmmX 		Synthase subclass: Type II
Saccharide-specific information
Subclass oligosaccharide
Glycosyltransferases
cmmGI
Specificity: D-oliose
Evidence:
  • Knock-out construct
cmmGIII
Specificity: D-olivose
Evidence:
  • Knock-out construct
cmmGIV
Specificity: D-olivose
Evidence:
  • Knock-out construct
cmmGII
Specificity: D-oliose
Evidence:
  • Knock-out construct
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: QGSJT55NWIBPAZQIATLZ7G55, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed duplicate gene annotation
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A glossary is available here.
Selected features only
Show module domains
Similar known gene clusters
Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Click on reference genes to show details of similarities to genes within the current region.
Click on an accession to open that entry in the MiBIG database.