BGC0000211 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000211 (Streptomyces albaduncus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	34,654	High	chrysomycin	PKS

BGC0000211 - Region 1 - T2PKS

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Location: 1 - 34,654 nt. (total: 34,654 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,655
Label		BGC0000211

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

chryF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

chryOI: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

chryOIII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

chryOIV: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

chryRM: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

chryX9: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: acylase glycosyltransferase kinase methyltransferase transferase

chryD: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

chryGT: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

chryMT: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

chryP: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

chryQ: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

chryX4: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: cyclase dehydratase

chryE: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

chryG: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

chryK: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

chryU: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

chryA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

chryB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000211.5	1.00	PKS	chrysomycin	Streptomyces albaduncus
BGC0000231.5	0.73	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000263.5	0.60	PKS	ravidomycin	Streptomyces ravidus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0000253.4	0.56	PKS	oviedomycin	Streptomyces antibioticus
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000211.5	1.00	PKS	chrysomycin	Streptomyces albaduncus
BGC0000231.5	0.73	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0000263.5	0.60	PKS	ravidomycin	Streptomyces ravidus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089
BGC0000253.4	0.56	PKS	oviedomycin	Streptomyces antibioticus
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

chryP: mal

PKS_AT (6..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 70.7
Methylmalonyl-CoA: 42.8
Methoxymalonyl-CoA: 30.4
inactive: 24.4
Ethylmalonyl-CoA: 24.2
Propionyl-CoA: 22.4
trans-1,2-CPDA: 9.7
Acetyl-CoA: 8.4
2-Methylbutyryl-CoA: 3.4
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

chryQ: mal

PKS_AT (10..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 36.5
Methoxymalonyl-CoA: 24.9
Methylmalonyl-CoA: 22.0
inactive: 14.0
Propionyl-CoA: 9.1
Isobutyryl-CoA: 7.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 34654
Starter unit(s):: propionyl-CoA (Score: 625.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 672.2; E-value: 5.2e-205)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 574 Da
propionyl-CoA_9: 616 Da

chryA: KS (Score: 776.3; E-value: 1.5e-236)
chryB: CLF 8|9 (Score: 672.2; E-value: 5.2e-205)
chryC: ACP (Score: 112.6; E-value: 1.5e-35)
chryC1: ACP (Score: 110.1; E-value: 9e-35)
chryF: KR C9 (Score: 458.3; E-value: 1.7e-140)
chryG: CYC C4-C17/C2-C19 (Score: 184.8; E-value: 3.6e-57)
chryGT: GT (Score: 380.6; E-value: 2.6e-116)
chryK: CYC C7-C12 (Score: 474.1; E-value: 3.6e-145)
chryMT: MET (Score: 296.5; E-value: 5.8e-91)
chryOI: OXY (Score: 561.3; E-value: 4.5e-171)
chryOIV: OXY (Score: 528.6; E-value: 3.6e-161)
chryQ: AT (Score: 399.0; E-value: 3.7e-122); AT CBH32094.1_Chrysomycin_propionyl-CoA (Score: 625.0; E-value: 0.0)