BGC0000211 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000211 (Streptomyces albaduncus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	34,654	chrysomycin	PKS	100%

BGC0000211 - Region 1 - T2PKS

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Location: 1 - 34,654 nt. (total: 34,654 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 34,655
Label		BGC0000211

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000211	1.00	Polyketide	chrysomycin	Streptomyces albaduncus
BGC0000231	0.42	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002435	0.32	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001924	0.31	Terpene	ascofuranone	Acremonium egyptiacum
BGC0002733	0.30	Other	sinapigladioside	Burkholderia gladioli
BGC0001723	0.28	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000263	0.27	Polyketide	ravidomycin	Streptomyces ravidus
BGC0001882	0.27	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000211	1.00	Polyketide	chrysomycin	Streptomyces albaduncus
BGC0000231	0.73	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002435	0.65	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001924	0.65	Terpene	ascofuranone	Acremonium egyptiacum
BGC0002733	0.63	Other	sinapigladioside	Burkholderia gladioli
BGC0001723	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000263	0.61	Polyketide	ravidomycin	Streptomyces ravidus
BGC0001882	0.61	Polyketide	chrysoxanthone A, chrysoxanthone B, chrysoxanthone C	Penicillium rubens Wisconsin 54-1255

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

chryP

PKS_AT (6..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 70.7
Methylmalonyl-CoA: 42.8
Methoxymalonyl-CoA: 30.4
inactive: 24.4
Ethylmalonyl-CoA: 24.2
Propionyl-CoA: 22.4
trans-1,2-CPDA: 9.7
Acetyl-CoA: 8.4
2-Methylbutyryl-CoA: 3.4
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

chryQ

PKS_AT (10..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 36.5
Methoxymalonyl-CoA: 24.9
Methylmalonyl-CoA: 22.0
inactive: 14.0
Propionyl-CoA: 9.1
Isobutyryl-CoA: 7.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 34654
Starter unit(s):: propionyl-CoA (Score: 625.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 672.2; E-value: 5.2e-205)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 574 Da
propionyl-CoA_9: 616 Da

chryA: KS (Score: 776.3; E-value: 1.5e-236)
chryB: CLF 8|9 (Score: 672.2; E-value: 5.2e-205)
chryC: ACP (Score: 112.6; E-value: 1.5e-35)
chryC1: ACP (Score: 110.1; E-value: 9e-35)
chryF: KR C9 (Score: 458.3; E-value: 1.7e-140)
chryG: CYC C4-C17/C2-C19 (Score: 184.8; E-value: 3.6e-57)
chryGT: GT (Score: 380.6; E-value: 2.6e-116)
chryK: CYC C7-C12 (Score: 474.1; E-value: 3.6e-145)
chryMT: MET (Score: 296.5; E-value: 5.8e-91)
chryOI: OXY (Score: 561.3; E-value: 4.5e-171)
chryOIV: OXY (Score: 528.6; E-value: 3.6e-161)
chryQ: AT (Score: 399.0; E-value: 3.7e-122); AT CBH32094.1_Chrysomycin_propionyl-CoA (Score: 625.0; E-value: 0.0)