BGC0000212: cinerubin B biosynthetic gene cluster from Streptomyces sp. SPB074
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Location: 5,086,070 - 5,121,186 nt. (total: 35,117 nt).
This entry is originally from NCBI GenBank GG770539.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000212
Short description cinerubin B biosynthetic gene cluster from Streptomyces sp. SPB074
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
GG770539.1
5086070 - 5121186
via
Compounds
  • cinerubin B
Species Streptomyces sp. SPB074 [taxonomy]
References
Chemical products information
cinerubin B Evidence:
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C42H51N1O16
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSBG_00478
  • EDY42516.1
 5086070 - 5086924 (-) daunorubicin resistance transmembrane protein
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    • SSBG_00479
    • EDY42517.2
    		 5086921 - 5087901 (-) daunorubicin resistance ATP-binding protein DrrA
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      • SSBG_00481
      • EDY42519.2
      		 5088108 - 5088728 (-) transcriptional regulator
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        • SSBG_00482
        • EDY42520.2
        		 5088907 - 5089341 (-) conserved hypothetical protein
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          • SSBG_00483
          • EDY42521.1
          		 5089593 - 5090402 (+) NAD dependent epimerase/dehydratase
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            • SSBG_00484
            • EDY42522.1
            		 5090416 - 5091144 (+) methyltransferase type 11
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              • SSBG_00485
              • EDY42523.2
              		 5091286 - 5092845 (-) secreted FAD-binding protein
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                • SSBG_00486
                • EDY42524.1
                		 5092951 - 5093430 (-) conserved hypothetical protein
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                  • SSBG_00487
                  • EDY42525.1
                  		 5093521 - 5094366 (-) transcriptional regulatory protein, C
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                    • SSBG_00488
                    • EDY42526.1
                    		 5094412 - 5094846 (-) conserved hypothetical protein
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                      • SSBG_00489
                      • EDY42527.1
                      		 5095047 - 5095907 (+) methyltransferase domain-containing protein
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                        • SSBG_00490
                        • EDY42528.2
                        		 5096050 - 5097147 (-) modular polyketide synthase
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                          • SSBG_00491
                          • EDY42529.1
                          		 5097144 - 5098208 (-) 3-oxoacyl-ACP synthase III
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                            • SSBG_00492
                            • EDY42530.1
                            		 5098205 - 5098483 (-) oxytetracycline polyketide synthase acyl carrier protein (ACP)
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                              • SSBG_00493
                              • EDY42531.1
                              		 5098574 - 5099812 (-) tetracenomycin C polyketide beta-ketoacyl synthase 2
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                                • SSBG_00494
                                • EDY42532.1
                                		 5099809 - 5101083 (-) tetracenomycin C polyketide beta-ketoacyl synthase 1
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                                  • SSBG_00495
                                  • EDY42533.2
                                  		 5101080 - 5101436 (-) antibiotic biosynthesis monooxygenase subfamily
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                                    • SSBG_00496
                                    • EDY42534.1
                                    		 5101668 - 5102453 (+) monensin polyketide synthase ketoacyl reductase
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                                      • SSBG_00497
                                      • EDY42535.1
                                      		 5102501 - 5103853 (+) granaticin polyketide synthase bifunctional cyclase/dehydratase
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                                        • SSBG_00498
                                        • EDY42536.1
                                        		 5104068 - 5105390 (+) glycosyltransferase family 28 domain-containing protein
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                                          • SSBG_00499
                                          • EDY42537.1
                                          		 5105391 - 5106008 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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                                            • SSBG_00500
                                            • EDY42538.2
                                            		 5106005 - 5106940 (+) NAD dependent epimerase/dehydratase
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                                              • SSBG_00501
                                              • EDY42539.2
                                              		 5107148 - 5108494 (+) dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
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                                                • SSBG_00502
                                                • EDY42540.1
                                                		 5108660 - 5109769 (-) daunorubicin biosynthesis sensory transduction protein DnrJ
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                                                  • SSBG_00503
                                                  • EDY42541.1
                                                  		 5109967 - 5110842 (+) glucose-1-phosphate thymidylyltransferase
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                                                    • SSBG_00504
                                                    • EDY42542.1
                                                    		 5110903 - 5111622 (-) methyltransferase type 11
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                                                      • SSBG_00505
                                                      • EDY42543.1
                                                      		 5111697 - 5112476 (-) cyclase superfamily protein
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                                                        • SSBG_00507
                                                        • EDY42544.1
                                                        		 5112676 - 5113110 (+) hydroxylacyl-CoA dehydrogenase
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                                                          • SSBG_00508
                                                          • EDY42546.1
                                                          		 5113094 - 5113924 (+) ketoreductase
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                                                            • SSBG_00509
                                                            • EDY42547.2
                                                            		 5113948 - 5115285 (+) conserved hypothetical protein
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                                                              • SSBG_00510
                                                              • EDY42548.2
                                                              		 5115304 - 5116620 (+) glycosyltransferase family 28 domain-containing protein
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                                                                • SSBG_00511
                                                                • EDY42549.1
                                                                		 5116617 - 5117603 (+) dTDP-glucose 4,6-dehydratase
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                                                                  • SSBG_00512
                                                                  • EDY42550.2
                                                                  		 5117846 - 5118744 (-) oxidoreductase family, NAD-binding Rossmann fold protein
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                                                                    • SSBG_00513
                                                                    • EDY42551.2
                                                                    		 5118889 - 5120211 (+) lipopolysaccharide biosynthesis protein RfbH
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                                                                      • SSBG_00514
                                                                      • EDY42552.1
                                                                      		 5120227 - 5121186 (-) transcriptional regulatory protein, C
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                                                                        Biosynthesis information
                                                                        Annotation changelog

                                                                        Entry version: 4

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-10-07
                                                                        Update chemical activity to schema version 2.11
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 3

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2022-09-15
                                                                        Updated bioactivity data
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 2

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2019-10-16
                                                                        Migrated from v1.4
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        2019-10-16
                                                                        Updated compound(s) information (NPAtlas curation)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                        Entry version: 1

                                                                        Date
                                                                        Changes
                                                                        Submitters
                                                                        Reviewers
                                                                        2015-06-12
                                                                        Submitted
                                                                        • (ID: V2N3X52B4LWFUVMTZQCN5CBN)
                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                        Detailed domain annotation
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