BGC0000212 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000212 (Streptomyces sp. SPB074)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,PKS-like	1	35,117	cinerubin B	PKS:Type II	100%

BGC0000212 - Region 1 - PKS-like,T2PKS

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Location: 1 - 35,117 nt. (total: 35,117 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 35,118
Label		BGC0000212

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000212	1.92	Polyketide	cinerubin B	Streptomyces sp. SPB074
BGC0000191	1.27	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000192	1.23	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000193	0.88	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000272	0.82	Polyketide	spore pigment	Streptomyces collinus
BGC0000217	0.77	Polyketide	daunorubicin	Streptomyces sp.
BGC0000231	0.69	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.66	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000218	0.65	Polyketide	doxorubicin	Streptomyces peucetius
BGC0002733	0.64	Other	sinapigladioside	Burkholderia gladioli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000212	1.00	Polyketide	cinerubin B	Streptomyces sp. SPB074
BGC0000191	0.86	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000192	0.85	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000193	0.81	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000272	0.73	Polyketide	spore pigment	Streptomyces collinus
BGC0000217	0.71	Polyketide	daunorubicin	Streptomyces sp.
BGC0000231	0.68	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.66	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000218	0.66	Polyketide	doxorubicin	Streptomyces peucetius
BGC0002733	0.65	Other	sinapigladioside	Burkholderia gladioli

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

SSBG_00490

PKS_AT (18..302): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 39.4
Methylmalonyl-CoA: 23.7
Methoxymalonyl-CoA: 23.4
Propionyl-CoA: 17.3
inactive: 11.6
Isobutyryl-CoA: 7.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 35117
Starter unit(s):: propionyl-CoA (Score: 992.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 674.1; E-value: 1.4e-205)
Product class(es):: anthracycline
Product molecular weight(s):: propionyl-CoA_8: 707 Da
propionyl-CoA_9: 749 Da

SSBG_00484: MET carboxy_O (Score: 225.6; E-value: 1.3e-69)
SSBG_00488: CYC C2-C19 (Score: 274.6; E-value: 3.2e-85)
SSBG_00489: MET carboxy_O (Score: 420.5; E-value: 5.1e-129)
SSBG_00490: AT (Score: 455.3; E-value: 2.9e-139); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 478.0; E-value: 1.08e-173)
SSBG_00491: KSIII (Score: 494.9; E-value: 2.7e-151); KSIII BAB72048.1_Aklavinone_propionyl-CoA (Score: 514.0; E-value: 0.0)
SSBG_00492: ACP (Score: 109.5; E-value: 1.4e-34)
SSBG_00493: CLF 8|9 (Score: 674.1; E-value: 1.4e-205)
SSBG_00494: KS (Score: 731.9; E-value: 4.7e-223)
SSBG_00496: KR C9 (Score: 480.1; E-value: 3.6e-147)
SSBG_00497: CYC C7-C12 (Score: 508.2; E-value: 1.5e-155)
SSBG_00498: GT (Score: 510.7; E-value: 8.1e-156)
SSBG_00505: CYC C5-C14/C3-C16 (Score: 441.2; E-value: 2.6e-135)
SSBG_00507: CYC C1-C18|C2-C19 (Score: 189.0; E-value: 8e-59)
SSBG_00508: KR C17 (Score: 467.7; E-value: 2e-143)
SSBG_00510: GT (Score: 458.6; E-value: 5.4e-140)