BGC0000212: cinerubin B biosynthetic gene cluster from Streptomyces sp. SPB074
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Location: 5,086,070 - 5,121,186 nt. (total: 35,117 nt).
This entry is originally from NCBI GenBank GG770539.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000212
Short description cinerubin B biosynthetic gene cluster from Streptomyces sp. SPB074
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Anthracycline)
Loci NCBI GenBank: GG770539.1
Compounds
  • cinerubin B
Species Streptomyces sp. SPB074 [taxonomy]
References
Chemical products information
cinerubin B
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C42H51N1O16
Chemical database entries
NPAtlas
ChemSpider
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SSBG_00478
  • EDY42516.1
 5086070 - 5086924 (-) daunorubicin resistance transmembrane protein
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  • SSBG_00479
  • EDY42517.2
 5086921 - 5087901 (-) daunorubicin resistance ATP-binding protein DrrA
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  • SSBG_00481
  • EDY42519.2
 5088108 - 5088728 (-) transcriptional regulator
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  • SSBG_00482
  • EDY42520.2
 5088907 - 5089341 (-) conserved hypothetical protein
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  • SSBG_00483
  • EDY42521.1
 5089593 - 5090402 (+) NAD dependent epimerase/dehydratase
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  • SSBG_00484
  • EDY42522.1
 5090416 - 5091144 (+) methyltransferase type 11
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  • SSBG_00485
  • EDY42523.2
 5091286 - 5092845 (-) secreted FAD-binding protein
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  • SSBG_00486
  • EDY42524.1
 5092951 - 5093430 (-) conserved hypothetical protein
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  • SSBG_00487
  • EDY42525.1
 5093521 - 5094366 (-) transcriptional regulatory protein, C
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  • SSBG_00488
  • EDY42526.1
 5094412 - 5094846 (-) conserved hypothetical protein
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  • SSBG_00489
  • EDY42527.1
 5095047 - 5095907 (+) methyltransferase domain-containing protein
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  • SSBG_00490
  • EDY42528.2
 5096050 - 5097147 (-) modular polyketide synthase
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  • SSBG_00491
  • EDY42529.1
 5097144 - 5098208 (-) 3-oxoacyl-ACP synthase III
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  • SSBG_00492
  • EDY42530.1
 5098205 - 5098483 (-) oxytetracycline polyketide synthase acyl carrier protein (ACP)
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  • SSBG_00493
  • EDY42531.1
 5098574 - 5099812 (-) tetracenomycin C polyketide beta-ketoacyl synthase 2
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  • SSBG_00494
  • EDY42532.1
 5099809 - 5101083 (-) tetracenomycin C polyketide beta-ketoacyl synthase 1
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  • SSBG_00495
  • EDY42533.2
 5101080 - 5101436 (-) antibiotic biosynthesis monooxygenase subfamily
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  • SSBG_00496
  • EDY42534.1
 5101668 - 5102453 (+) monensin polyketide synthase ketoacyl reductase
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  • SSBG_00497
  • EDY42535.1
 5102501 - 5103853 (+) granaticin polyketide synthase bifunctional cyclase/dehydratase
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  • SSBG_00498
  • EDY42536.1
 5104068 - 5105390 (+) glycosyltransferase family 28 domain-containing protein
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  • SSBG_00499
  • EDY42537.1
 5105391 - 5106008 (+) dTDP-4-dehydrorhamnose 3,5-epimerase
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  • SSBG_00500
  • EDY42538.2
 5106005 - 5106940 (+) NAD dependent epimerase/dehydratase
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  • SSBG_00501
  • EDY42539.2
 5107148 - 5108494 (+) dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
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  • SSBG_00502
  • EDY42540.1
 5108660 - 5109769 (-) daunorubicin biosynthesis sensory transduction protein DnrJ
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  • SSBG_00503
  • EDY42541.1
 5109967 - 5110842 (+) glucose-1-phosphate thymidylyltransferase
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  • SSBG_00504
  • EDY42542.1
 5110903 - 5111622 (-) methyltransferase type 11
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  • SSBG_00505
  • EDY42543.1
 5111697 - 5112476 (-) cyclase superfamily protein
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  • SSBG_00507
  • EDY42544.1
 5112676 - 5113110 (+) hydroxylacyl-CoA dehydrogenase
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  • SSBG_00508
  • EDY42546.1
 5113094 - 5113924 (+) ketoreductase
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  • SSBG_00509
  • EDY42547.2
 5113948 - 5115285 (+) conserved hypothetical protein
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  • SSBG_00510
  • EDY42548.2
 5115304 - 5116620 (+) glycosyltransferase family 28 domain-containing protein
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  • SSBG_00511
  • EDY42549.1
 5116617 - 5117603 (+) dTDP-glucose 4,6-dehydratase
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  • SSBG_00512
  • EDY42550.2
 5117846 - 5118744 (-) oxidoreductase family, NAD-binding Rossmann fold protein
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  • SSBG_00513
  • EDY42551.2
 5118889 - 5120211 (+) lipopolysaccharide biosynthesis protein RfbH
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  • SSBG_00514
  • EDY42552.1
 5120227 - 5121186 (-) transcriptional regulatory protein, C
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Polyketide-specific information
Subclass Anthracycline
Starter unit Propionyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
SSBG_00488
+
SSBG_00497
+
SSBG_00505
+
SSBG_00494 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: V2N3X52B4LWFUVMTZQCN5CBN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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