BGC0000213 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000213 (Streptomyces aureus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	HR-T2PKS,furan	1	46,538	High	colabomycin E	PKS:Type II

BGC0000213 - Region 1 - HR-T2PKS,furan

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Location: 1 - 46,538 nt. (total: 46,538 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))
furan: (mmyO or AvrD)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 46,539
Label		BGC0000213

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AIL50160.1: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

colC10: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

colC7: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

colE1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

colE2: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

Transferases: PPTase

colC1: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase peptidase

AIL50153.1: gamma-glutamyltranspeptidase

smcogs: SMCOG1274: gamma-glutamyltranspeptidase

colC15: thioesterase

smcogs: SMCOG1004: thioesterase

colC6: thioesterase superfamily protein

smcogs: SMCOG1144: thioesterase superfamily protein

Ligases: ligase synthase

colA2: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

colC13: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

colC3: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

colC4: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

colD1: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

colD2: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

colD3: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000213.4	1.33	PKS	colabomycin E	Streptomyces aureus
BGC0001160.5	0.52	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0002826.2	0.37	other (other)	closoxazole A, closoxazole B	Clostridium cavendishii DSM 21758
BGC0001917.4	0.36	PKS	5aTHQ-9i, 5aTHQ-9n, 5aTHQ-10a, STAMs-9i, STAMs-9n	Streptomyces nigrescens
BGC0001987.2	0.36	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0001928.2	0.34	other (other)	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002510.2	0.34	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0001197.5	0.33	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001295.5	0.33	other (other)	cremeomycin	Streptomyces cremeus
BGC0000889.5	0.33	other (other)	bagremycin A, bagremycin B	Streptomyces sp. WK-5344

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000213.4	0.98	PKS	colabomycin E	Streptomyces aureus
BGC0002193.2	0.63	other (other)	phenguignardic acid	Aspergillus terreus NIH2624
BGC0002274.2	0.62	NRPS	aspulvinone H, aspulvinone B1	Aspergillus terreus NIH2624
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001268.4	0.60	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0001164.3	0.59	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

colA2: X

AMP-binding (23..372): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLGFVGAIIK
Nearest Stachelhaus code(s):: nohBza GLGLVGAIIK (97% 8Å match)
Stachelhaus code match:: 90% (moderate)

colD3: Hpr

Search NORINE for peptide: strict or relaxed

AMP-binding (9..404): Hpr

nrpys: Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: pip (Hpr)

Stachelhaus prediction details:

Stachelhaus sequence:: TFCMFGGPVK
Nearest Stachelhaus code(s):: nLev GFCMYGGCSK (79% 8Å match)
Stachelhaus code match:: 60% (weak)

colD1: X

AMP-binding (26..419): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TVMLITGRVK
Nearest Stachelhaus code(s):: Ala DVGWITGIVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor