Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000213.1:
Cluster 1Polyketide146538

BGC0000213, colabomycin biosynthetic gene cluster from Streptomyces aureus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: colabomycin E
SMILES string: Copy to clipboard
Molecular formula: C32H32N2O7
Exact molecular mass: 555.2131 Da ([M-H]-)
Molecular activity: Antibacterial, Inhibitor
Molecular target: caspase 1

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyene (linear)
Polyketide synthase subclass:
Type II
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
AIL50179.1,AIL50166.1

Gene cluster description

colabomycin (BGC0000213). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KF850685, positions 14631-44136. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Miroslav Petricek (Institute of Microbiology ASCR)

Literature references

1. Petrickova K et al. (2014) Biosynthesis of colabomycin E, a new manumycin-family metabolite, involves an unusual chain-length factor. Chembiochem 15(9):1334-45. doi: 10.1002/cbic.201400068. Epub 2014