BGC0000214 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000214 (Streptomyces olindensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like,T2PKS	1	14,080	High	cosmomycin B	PKS

BGC0000214 - Region 1 - PKS-like,T2PKS

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Location: 1 - 14,080 nt. (total: 14,080 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,081
Label		BGC0000214

Tailoring functions

Oxidoreductases: oxygenase

cosT: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase glycosyltransferase

cosF: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

cosG: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

cosk: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Hydrolases: deaminase

cosY: ornithine cyclodeaminase

smcogs: SMCOG1158: ornithine cyclodeaminase

Lyases: dehydratase

cosH: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

cosB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

cosC: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

cosE: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000214.5	2.00	PKS	cosmomycin B	Streptomyces olindensis
BGC0001074.5	0.78	PKS, saccharide	cosmomycin D	Streptomyces olindensis
BGC0001558.5	0.60	PKS	cosmomycin C	Streptomyces sp. CNT302
BGC0001568.5	0.60	PKS	cytorhodin	Streptomyces sp. SCSIO 1666
BGC0000217.5	0.58	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	0.56	PKS	doxorubicin	Streptomyces peucetius
BGC0002154.2	0.52	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000231.5	0.51	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001160.5	0.50	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000272.3	0.49	PKS	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000214.5	1.00	PKS	cosmomycin B	Streptomyces olindensis
BGC0001074.5	0.71	PKS, saccharide	cosmomycin D	Streptomyces olindensis
BGC0001558.5	0.64	PKS	cosmomycin C	Streptomyces sp. CNT302
BGC0001568.5	0.63	PKS	cytorhodin	Streptomyces sp. SCSIO 1666
BGC0000217.5	0.62	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	0.61	PKS	doxorubicin	Streptomyces peucetius
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000231.5	0.59	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001160.5	0.58	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000272.3	0.58	PKS	spore pigment	Streptomyces collinus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

cosF: mal

PKS_AT (21..314): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 49.7
Methoxymalonyl-CoA: 34.2
Methylmalonyl-CoA: 29.1
Propionyl-CoA: 16.5
inactive: 11.8
Isobutyryl-CoA: 9.0
2-Methylbutyryl-CoA: 8.9
Acetyl-CoA: 8.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 14080
Starter unit(s):: propionyl-CoA (Score: 1347.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 651.5; E-value: 9.7e-199)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracenomycin
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 753 Da
propionyl-CoA_9: 795 Da

cosB: KS (Score: 747.6; E-value: 7.8e-228)
cosC: CLF 8|9 (Score: 651.5; E-value: 9.7e-199)
cosE: KSIII (Score: 536.2; E-value: 7.2e-164); KSIII ABC00733.1_Cosmomycin_propionyl-CoA (Score: 685.0; E-value: 0.0)
cosF: AT (Score: 447.0; E-value: 9.3e-137); AT ABC00730.1_Cosmomycin_propionyl-CoA (Score: 662.0; E-value: 0.0)
cosG: GT (Score: 467.9; E-value: 8e-143)
cosk: GT (Score: 446.9; E-value: 1.9e-136)