BGC0000215 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000215 (Streptomyces cyaneus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	5,469	High	curamycin	PKS

BGC0000215 - Region 1 - T2PKS

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Location: 1 - 5,469 nt. (total: 5,469 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 5,470
Label		BGC0000215

Tailoring functions

Lyases: cyclase

CurF: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

CurG: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

CurA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CurB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000215.5	1.00	PKS	curamycin	Streptomyces cyaneus
BGC0000272.3	0.75	PKS	spore pigment	Streptomyces collinus
BGC0000271.5	0.74	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.61	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001366.5	0.58	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000234.5	0.56	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001512.5	0.55	PKS	BE-24566B	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000215.5	1.00	PKS	curamycin	Streptomyces cyaneus
BGC0000272.3	0.75	PKS	spore pigment	Streptomyces collinus
BGC0000271.5	0.74	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.61	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000275.4	0.60	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001366.5	0.58	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000234.5	0.56	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001512.5	0.55	PKS	BE-24566B	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 5469:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal)
Non-colinear ordering:: CurB + CurE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

Type II PKS gene cluster prediction details

Cluster section:: 0 to 5469
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Product class(es):: pentangular polyphenol
tetracenomycin

CurA: KS (Score: 738.0; E-value: 6.4e-225)
CurB: CLF (Score: 522.6; E-value: 1.4e-159)
CurC: CYC C5-C18 (Score: 220.0; E-value: 1.8e-68)
CurE: ACP (Score: 61.6; E-value: 1.3e-19)
CurF: CYC C9-C14 (Score: 253.1; E-value: 1.7e-78)
CurG: CYC C4-C21/C2-C23|C2-C19 (Score: 145.5; E-value: 1.1e-45)