BGC0000217 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000217 (Streptomyces sp)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T2PKS	1	8,089	daunorubicin	PKS	100%

BGC0000217 - Region 1 - PKS-like,T2PKS

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Location: 1 - 8,089 nt. (total: 8,089 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,090
Label		BGC0000217

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000217	2.00	Polyketide	daunorubicin	Streptomyces sp.
BGC0000218	1.22	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000231	0.61	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000192	0.49	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000272	0.48	Polyketide	spore pigment	Streptomyces collinus
BGC0000234	0.48	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197	0.45	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001723	0.42	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000205	0.41	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000214	0.40	Polyketide	cosmomycin B	Streptomyces olindensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000217	1.00	Polyketide	daunorubicin	Streptomyces sp.
BGC0000218	0.85	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000231	0.64	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000192	0.58	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000272	0.57	Polyketide	spore pigment	Streptomyces collinus
BGC0000234	0.57	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197	0.56	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001723	0.54	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000205	0.53	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0000214	0.53	Polyketide	cosmomycin B	Streptomyces olindensis

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AAA87621.1

PKS_AT (8..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 45.3
Methylmalonyl-CoA: 33.7
Methoxymalonyl-CoA: 28.9
Propionyl-CoA: 22.3
inactive: 17.5
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 8089
Starter unit(s):: propionyl-CoA (Score: 1250.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 616.0; E-value: 5.9e-188)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 394 Da
propionyl-CoA_9: 436 Da

AAA87618.1: KS (Score: 709.6; E-value: 2.7e-216)
AAA87619.1: CLF 8|9 (Score: 616.0; E-value: 5.9e-188)
AAA87620.1: KSIII (Score: 465.1; E-value: 3.1e-142); KSIII WP_100109100.1_Doxorubicin_propionyl-CoA (Score: 591.0; E-value: 0.0)
AAA87621.1: AT (Score: 429.5; E-value: 1.9e-131); AT AAA87621.1_Daunomycin_propionyl-CoA (Score: 659.0; E-value: 0.0)
dauA: CYC C7-C12 (Score: 440.9; E-value: 4.6e-135)
dauB: KR C9 (Score: 431.4; E-value: 2.6e-132)
dauC: MET carboxy_O (Score: 263.4; E-value: 3.7e-81)