BGC0000217 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000217 (Streptomyces sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	PKS-like,T2PKS	1	8,089	High	daunorubicin	PKS

BGC0000217 - Region 1 - PKS-like,T2PKS

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Location: 1 - 8,089 nt. (total: 8,089 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,090
Label		BGC0000217

Tailoring functions

Oxidoreductases: dehydrogenase

dauB: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase methyltransferase

AAA87621.1: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

dauC: methyltransferase

smcogs: SMCOG1089: methyltransferase

Lyases: cyclase

dauA: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

AAA87618.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AAA87619.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AAA87620.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000217.5	2.00	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	1.22	PKS	doxorubicin	Streptomyces peucetius
BGC0000231.5	0.61	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.55	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.54	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000192.3	0.49	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000272.3	0.48	PKS	spore pigment	Streptomyces collinus
BGC0000234.5	0.48	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.42	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000217.5	1.00	PKS	daunorubicin	Streptomyces sp.
BGC0000218.5	0.85	PKS	doxorubicin	Streptomyces peucetius
BGC0000231.5	0.64	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.61	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.60	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0000192.3	0.58	PKS	aclacinomycin	Streptomyces galilaeus
BGC0000272.3	0.57	PKS	spore pigment	Streptomyces collinus
BGC0000234.5	0.57	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.54	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AAA87621.1: mal

PKS_AT (8..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 45.3
Methylmalonyl-CoA: 33.7
Methoxymalonyl-CoA: 28.9
Propionyl-CoA: 22.3
inactive: 17.5
2-Methylbutyryl-CoA: 9.5
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 8089
Starter unit(s):: propionyl-CoA (Score: 1250.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 616.0; E-value: 5.9e-188)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 394 Da
propionyl-CoA_9: 436 Da

AAA87618.1: KS (Score: 709.6; E-value: 2.7e-216)
AAA87619.1: CLF 8|9 (Score: 616.0; E-value: 5.9e-188)
AAA87620.1: KSIII (Score: 465.1; E-value: 3.1e-142); KSIII WP_100109100.1_Doxorubicin_propionyl-CoA (Score: 591.0; E-value: 0.0)
AAA87621.1: AT (Score: 429.5; E-value: 1.9e-131); AT AAA87621.1_Daunomycin_propionyl-CoA (Score: 659.0; E-value: 0.0)
dauA: CYC C7-C12 (Score: 440.9; E-value: 4.6e-135)
dauB: KR C9 (Score: 431.4; E-value: 2.6e-132)
dauC: MET carboxy_O (Score: 263.4; E-value: 3.7e-81)