BGC0000218 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000218 (Streptomyces peucetius)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,PKS-like	1	8,737	doxorubicin	PKS	100%

BGC0000218 - Region 1 - PKS-like,T2PKS

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Location: 1 - 8,737 nt. (total: 8,737 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
PKS-like: (t2pks2 or ksIII)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 8,738
Label		BGC0000218

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000218	2.00	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000217	1.40	Polyketide	daunorubicin	Streptomyces sp.
BGC0000231	0.62	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000192	0.51	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000234	0.51	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272	0.48	Polyketide	spore pigment	Streptomyces collinus
BGC0001197	0.45	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001723	0.45	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000214	0.43	Polyketide	cosmomycin B	Streptomyces olindensis
BGC0000888	0.43	Other	bacilysin	Bacillus sp. CS93

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000218	1.00	Polyketide	doxorubicin	Streptomyces peucetius
BGC0000217	0.89	Polyketide	daunorubicin	Streptomyces sp.
BGC0000231	0.64	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000192	0.59	Polyketide	aclacinomycin	Streptomyces galilaeus
BGC0000234	0.59	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272	0.58	Polyketide	spore pigment	Streptomyces collinus
BGC0001197	0.55	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0001723	0.55	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000214	0.54	Polyketide	cosmomycin B	Streptomyces olindensis
BGC0000888	0.54	Other	bacilysin	Bacillus sp. CS93

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

dpsD

PKS_AT (8..290): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 52.3
Methylmalonyl-CoA: 33.7
Methoxymalonyl-CoA: 31.8
Propionyl-CoA: 26.3
inactive: 20.1
2-Methylbutyryl-CoA: 9.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 8737
Starter unit(s):: propionyl-CoA (Score: 1354.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 652.2; E-value: 5.9e-199)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 396 Da
propionyl-CoA_9: 438 Da

AAA65210.1: MET carboxy_O (Score: 374.6; E-value: 4.9e-115)
dnrH: KR C17 (Score: 380.6; E-value: 7.3e-117)
dpsA: KS (Score: 728.0; E-value: 7.2e-222)
dpsB: CLF 8|9 (Score: 652.2; E-value: 5.9e-199)
dpsC: KSIII (Score: 519.2; E-value: 1.1e-158); KSIII WP_100109100.1_Doxorubicin_propionyl-CoA (Score: 700.0; E-value: 0.0)
dpsD: AT (Score: 423.5; E-value: 1.3e-129); AT WP_100109099.1_Doxorubicin_propionyl-CoA (Score: 654.0; E-value: 0.0)
dpsE: KR C9 (Score: 453.7; E-value: 4e-139)
dpsF: CYC C7-C12 (Score: 444.0; E-value: 5.1e-136)