BGC0000219 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000219 (Streptomyces olivaceus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	24,201	High	elloramycin	PKS:Type II+saccharide:hybrid/tailoring

BGC0000219 - Region 1 - T2PKS

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Location: 1 - 24,201 nt. (total: 24,201 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,202
Label		BGC0000219

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CAP12610.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

elmG: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: glycosyltransferase methyltransferase

elmGT: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

elmNII: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

CAP12591.1: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

CAP12611.1: alpha/beta hydrolase domain-containing protein

smcogs: SMCOG1066: alpha/beta hydrolase domain-containing protein

Lyases: cyclase

elmI: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

elmNI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

elmK: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

elmL: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Translocases: transporter

CAP12612.1: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000219.4	1.00	PKS, saccharide	elloramycin	Streptomyces olivaceus
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000204.5	0.59	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001197.5	0.59	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000221.5	0.56	PKS	erdacin	uncultured soil bacterium V167
BGC0001723.5	0.56	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000219.4	1.00	PKS, saccharide	elloramycin	Streptomyces olivaceus
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000275.4	0.59	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000204.5	0.59	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001197.5	0.59	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000221.5	0.56	PKS	erdacin	uncultured soil bacterium V167
BGC0001723.5	0.56	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 24201
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 631.1; E-value: 1.5e-192)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 618 Da
acetyl-CoA_9: 660 Da

CAP12610.1: KR (Score: 186.3; E-value: 1.8e-57)
elmD: MET carboxy_O (Score: 283.4; E-value: 3e-87)
elmF: MET (Score: 31.8; E-value: 1.8e-10)
elmG: OXY (Score: 340.5; E-value: 4.1e-104)
elmGT: GT (Score: 311.9; E-value: 2e-95)
elmI: CYC C4-C21/C2-C23|C2-C19 (Score: 133.2; E-value: 7.4e-42)
elmJ: CYC C5-C18 (Score: 199.2; E-value: 4.6e-62)
elmK: KS (Score: 734.2; E-value: 9.6e-224)
elmL: CLF 8|9 (Score: 631.1; E-value: 1.5e-192)
elmM: ACP (Score: 103.6; E-value: 1e-32)
elmMI: MET (Score: 58.9; E-value: 1.1e-18)
elmMII: MET C18O (Score: 350.8; E-value: 2.2e-107)
elmMIII: MET (Score: 22.3; E-value: 1.4e-07)
elmNI: CYC C9-C14 (Score: 234.9; E-value: 6.6e-73)
elmNII: MET C11O (Score: 528.2; E-value: 1.7e-161)
elmP: MET carboxy_O (Score: 276.4; E-value: 4e-85)