BGC0000219: elloramycin biosynthetic gene cluster from Streptomyces olivaceus
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Location: 1 - 24,201 nt. (total: 24,201 nt).
This entry is originally from NCBI GenBank AM900040.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000219
Short description elloramycin biosynthetic gene cluster from Streptomyces olivaceus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "Elloramycin is a hybrid compound comprising a tetracenomycin scaffold and a sugar moiety. A second genomic loci comprises the Rha cluster - accession number: AM889123, Responsible for saccharide biosynthesis. Biosynthesis is discussed in PubMed ID: 18310024."
Biosynthetic class(es)
  • Polyketide (Tetracenomycin)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: AM900040.1
Compounds
  • elloramycin
Species Streptomyces olivaceus [taxonomy]
References
Chemical products information
elloramycin
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C32H36O15
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAP12590.1
 3 - 404 (+) dehydrogenase
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  • CAP12591.1
 414 - 1085 (+) phosphatase
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  • CAP12592.1
 1169 - 1720 (+) membrane protein
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  • CAP12593.1
  • elmD
 1920 - 2807 (+) C12a O-methyltransferase
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  • CAP12594.1
  • elmE
 3099 - 4658 (+) elloramycin permease
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  • CAP12595.1
  • elmF
 4676 - 5875 (+) ElmF protein
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  • CAP12596.1
  • elmG
 6162 - 7781 (+) TcmB2 oxygenase
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  • CAP12597.1
  • elmH
 7813 - 8142 (+) TcmF1 monooxygenase
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  • CAP12598.1
  • elmI
 8169 - 8459 (+) TcmF2 cyclase
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  • CAP12599.1
  • elmJ
 8471 - 8902 (+) third ring cyclase
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  • CAP12600.1
  • elmK
 8899 - 10170 (+) ketoacyl synthase alpha
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  • CAP12601.1
  • elmL
 10167 - 11402 (+) ketoacyl synthase beta
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  • CAP12602.1
  • elmM
 11429 - 11680 (+) acyl carrier protein
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  • CAP12603.1
  • elmNI
 11677 - 12135 (+) aromatase
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  • CAP12604.1
  • elmNII
 12132 - 13181 (+) C3 O-methyltransferase
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  • CAP12605.1
  • elmP
 13178 - 14008 (+) carboxyl O-methyltransferase
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  • CAP12606.1
  • elmMI
 14028 - 15164 (+) rhamnose C2'-methyltransferase
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  • CAP12607.1
  • elmGT
 15166 - 16314 (+) glycosyltransferase
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  • CAP12608.1
  • elmMII
 16311 - 17483 (+) rhamnose C3'-methyltransferase
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  • CAP12609.1
  • elmMIII
 17510 - 18295 (+) rhamnose C4'-methyltransferase
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  • CAP12610.1
 18668 - 19450 (+) dehydrogenase
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  • CAP12611.1
 19447 - 20376 (+) lipase
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  • CAP12612.1
 20417 - 21655 (-) solute binding protein
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  • CAP12613.1
 21952 - 23718 (-) VanW-like protein
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  • CAP12614.1
 23835 - >24201 (+) IclR-family regulator
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Polyketide-specific information
Subclass Tetracenomycin
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
elmM
+
elmI
+
elmK
+
elmNI
+
elmJ 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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