Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000219.1:
Cluster 1Polyketide / Saccharide124201

BGC0000219, elloramycin biosynthetic gene cluster from Streptomyces olivaceus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: elloramycin
SMILES string: Copy to clipboard
Molecular formula: C32H38O15
Exact molecular mass: 663.64 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Tetracenomycin (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
CAP12600.1,CAP12602.1
Genes involved in folding/cyclization:
CAP12598.1,CAP12599.1,CAP12603.1,

Gene cluster description

elloramycin (BGC0000219). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank AM900040. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Comments:Elloramycin is a hybrid compound comprising a tetracenomycin scaffold and a sugar moiety. A second genomic loci comprises the Rha cluster - accession number: AM889123, Responsible for saccharide biosynthesis. Biosynthesis is discussed in PubMed ID: 18310024.
Contact for this cluster:Jose A. Salas (University of Oviedo)

Literature references

1. Ramos A et al. (2008) Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology 154(Pt 3):781-8. doi: 10.1099/mic.0.2007/014035-0.