LOCUS       BGC0000220             22511 bp    DNA     linear   BCT 01-JUL-2002
DEFINITION  Streptomyces maritimus enterocin biosynthetic gene cluster, complete
            sequence.
ACCESSION   BGC0000220
VERSION     BGC0000220
KEYWORDS    .
SOURCE      Streptomyces maritimus
  ORGANISM  Streptomyces maritimus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:12:34
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 22511
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..22511
                     /db_xref="taxon:115828"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces maritimus"
     protocluster    1..22511
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[8814:11306]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 734.8; E-value:
                     5e-224)"
                     /t2pks_molecular_weights="benzoyl-CoA_7 (Da): 416.421"
                     /t2pks_starter_units="benzoyl-CoA (Score: 2839.0; E-value:
                     0)"
                     /tool="antismash"
     proto_core      8815..11306
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="7 (Score: 734.8; E-value:
                     5e-224)"
                     /t2pks_molecular_weights="benzoyl-CoA_7 (Da): 416.421"
                     /t2pks_starter_units="benzoyl-CoA (Score: 2839.0; E-value:
                     0)"
     cand_cluster    1..22511
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..22511
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000220"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22511
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            513..1004
                     /gene="encE"
     CDS             513..1004
                     /codon_start=1
                     /gene="encE"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     118.5; E-value: 7.7e-36)"
                     /gene_kind="regulatory"
                     /product="putative regulatory protein EncE"
                     /protein_id="AAF81720.1"
                     /transl_table=11
                     /translation="MAQERRMQIGEVAERTGLSLRTIRHYEEVGLIVPSARSKGGFPLY
                     TQADVSRLMVIRRMKPLDFSLEEMRDLLEITDRLGAQDDPPAPVERERLRERLDAYRKV
                     ADARCETLRARLAMAEDFAATWRDGMNADARARSASERATSGGPLRRLWLTSDAPGLAG
                     "
     gene            1749..2600
                     /gene="encF"
     CDS             1749..2600
                     /codon_start=1
                     /gene="encF"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     302; E-value: 1.7e-91)"
                     /gene_kind="regulatory"
                     /product="putative transcriptional regulator EncF"
                     /protein_id="AAF81721.1"
                     /transl_table=11
                     /translation="MDVEVLGHVTLKVGDERRTPSAPKARQVLALLLVNANRMVSTDVL
                     IEELWAEQPPRSALSALQTYVFQLRQLLRKIRPDECPKQLLVTTPNGYEFRVPPENVDL
                     QRYERHRLAGQQAFQSGENMAAVEQFRAALHIFAAPPLANVRRGMHLEAEIVRLEESRI
                     GVQETRIEAELELGRHHEVLSELSGLASQCPQHEGFHRQLMLALYRCGRRPQALKVFNQ
                     LRQSLVTELGLEPSRELQMLQQAILSADPRLDTAERTPFLRTTADPAPLQVPWPAASPW
                     KV"
     gene            complement(2672..3163)
                     /gene="encG"
     CDS             complement(2672..3163)
                     /codon_start=1
                     /gene="encG"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C1-C18|C2-C19 (Score: 175.5; E-value: 1.1e-54)"
                     /gene_kind="biosynthetic-additional"
                     /product="EncG"
                     /protein_id="AAF81722.1"
                     /transl_table=11
                     /translation="MTTAGADPTQAEESALTQAPHKPEETAALFAEIQQFYGRHMRAMD
                     EGRVEDWTGDFMPDAVFATNARPEPQRGRAEIARNAEAAARQLQEKGILRRHCVTTLEL
                     QQASGLTLLAKTYALITKTVVGGRSELEFVCTCEDVLVRNEGRWFIRHRQVFRDDLPKR
                     "
     gene            3330..4937
                     /gene="encH"
     CDS             3330..4937
                     /NRPS_PKS="Domain: AMP-binding (35-422). E-value: 1.5e-86.
                     Score: 282.4. Matches aSDomain:
                     nrpspksdomains_encH_AMP-binding.1"
                     /codon_start=1
                     /gene="encH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     371.1; E-value: 1.2e-112)"
                     /gene_functions="biosynthetic-additional (t2pks) LIG
                     (Score: 677.9; E-value: 1.7e-206)"
                     /gene_functions="biosynthetic-additional (t2pks) LIG
                     AAF81723.1_Enterocin_benzoyl-CoA (Score: 1093.0; E-value:
                     0)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl-CoA ligase EncH"
                     /protein_id="AAF81723.1"
                     /sec_met_domain="AMP-binding (E-value: 1.2e-94, bitscore:
                     307.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPAPQAPTQPVIDARRPEAGPRWETIGELIKDAALLHGDKEFLR
                     CGDKTLSFSETDTRTDRLAQALIAQGVKPGDRVAVMMDNVADWPLSWFAAIKAGAITVP
                     VNTRFGATDLAHVLKDSQAVRVLASPGCVPLARDVSGSIGHPCAVRTLRELEADFGDRP
                     VDGPGLSAHADDTVNFQYTSGTTGFPKACMLSHDYWLRTAWMIAVHSGLRPDDVVLTAQ
                     AFSYMDPQWKAVMCLMGGVPLVVLPRFSASGFWHSVRQHRATLTYVLGSMPMLLYKQPP
                     HSGDRDHAMRLVLCSGIPRDLHHAFEDRWGAAWREVYGSTESGLDLIMPPGEEATVGSG
                     AMGYPPSGKEVIVADERQRPVQPGQIGEILVRGRPMMKGYWNNPDSTERAFRGGWYHTG
                     DLGRAEAAGSVVHAGRLKDMIRRGGENIAAAEVESVLEAHPAVLAAALAGIPDELFGEL
                     PKAFLQLRPGYRPTTATARSVLAHTRRHLAKFKVPAYVEFVDSFPMTPSARIQKRQLLR
                     PGDDQRTGAFDAAADAWA"
     aSDomain        3435..4595
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encH_AMP-binding.1"
                     /evalue="1.50E-86"
                     /label="encH_AMP-binding.1"
                     /locus_tag="encH"
                     /protein_end="422"
                     /protein_start="35"
                     /score="282.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LLHGDKEFLRCGDKTLSFSETDTRTDRLAQALIAQGVKPGDRVAV
                     MMDNVADWPLSWFAAIKAGAITVPVNTRFGATDLAHVLKDSQAVRVLASPGCVPLARDV
                     SGSIGHPCAVRTLRELEADFGDRPVDGPGLSAHADDTVNFQYTSGTTGFPKACMLSHDY
                     WLRTAWMIAVHSGLRPDDVVLTAQAFSYMDPQWKAVMCLMGGVPLVVLPRFSASGFWHS
                     VRQHRATLTYVLGSMPMLLYKQPPHSGDRDHAMRLVLCSGIPRDLHHAFEDRWGAAWRE
                     VYGSTESGLDLIMPPGEEATVGSGAMGYPPSGKEVIVADERQRPVQPGQIGEILVRGRP
                     MMKGYWNNPDSTERAFRGGWYHTGDLGRAEAAGSVVHAGRLKDMIRR"
     CDS_motif       3870..3917
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encH_0001"
                     /evalue="6.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="encH"
                     /protein_end="196"
                     /protein_start="180"
                     /score="18.7"
                     /tool="antismash"
                     /translation="YTSGTTGFPKACMLSH"
     CDS_motif       4416..4502
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encH_0002"
                     /evalue="9.40E-08"
                     /label="NRPS-A_a6"
                     /locus_tag="encH"
                     /protein_end="391"
                     /protein_start="362"
                     /score="24.4"
                     /tool="antismash"
                     /translation="PGQIGEILVRGRPMMKGYWNNPDSTERAF"
     gene            4934..5710
                     /gene="encI"
     CDS             4934..5710
                     /NRPS_PKS="Domain: ECH (15-239). E-value: 1.2e-44. Score:
                     144.3. Matches aSDomain: nrpspksdomains_encI_ECH.1"
                     /codon_start=1
                     /gene="encI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 182.8; E-value:
                     1.1e-55)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative enoyl-CoA hydratase EncI"
                     /protein_id="AAF81724.1"
                     /transl_table=11
                     /translation="MSDVQQLLSSADLTVTVDSDVAVIAMSRPAKLNALTRGMRRDLAE
                     LLRHYGDGSQARGVVITGQAKAFSAGMDLREVAGPEVDLLAEMELFNDITRAALITEVP
                     VVAALNGIAVGGAGEMALSFDARIATAQAAISWPETGVGLTVSNAASLFLPRLAGAPRA
                     LHLIMNSARLSASQALALGLLDDIVEPDDLIPAAIRLIHQWTPPGSSTAAHLRLMRPSL
                     RAVEAAMAREGAAVRQVQESGIAQAGIATVLAGHEK"
     aSDomain        4979..5650
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encI_ECH.1"
                     /evalue="1.20E-44"
                     /label="encI_ECH.1"
                     /locus_tag="encI"
                     /protein_end="239"
                     /protein_start="15"
                     /score="144.3"
                     /tool="antismash"
                     /translation="TVDSDVAVIAMSRPAKLNALTRGMRRDLAELLRHYGDGSQARGVV
                     ITGQAKAFSAGMDLREVAGPEVDLLAEMELFNDITRAALITEVPVVAALNGIAVGGAGE
                     MALSFDARIATAQAAISWPETGVGLTVSNAASLFLPRLAGAPRALHLIMNSARLSASQA
                     LALGLLDDIVEPDDLIPAAIRLIHQWTPPGSSTAAHLRLMRPSLRAVEAAMAREGAAVR
                     QV"
     gene            complement(5856..7058)
                     /gene="encJ"
     CDS             complement(5856..7058)
                     /codon_start=1
                     /gene="encJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124:acetyl-CoA acetyltransferase (Score: 281.1;
                     E-value: 2.1e-85)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative beta-oxoacyl-CoA thiolase EncJ"
                     /protein_id="AAF81725.1"
                     /transl_table=11
                     /translation="MTSGATYRDAAIPLTALWTSPFARWGGALSHLSSLDLAVAATGRA
                     LSERGIDRDTIEGMVLGWTVPQPAIFYGATTLAARLGMPQVSGPMLNQACATSVAALHQ
                     AAAAVGTGVGPQLIVTTDRTSNGPDLSWPSPAGSEQGPVRENWVRDSFSQDPVTGQSML
                     ATAEAVAAECGFTRDDLDALAVLRSEQYTAALSDDRTFQRDFMVGIEIEQDGLGTVRLL
                     SDEGVRPVTADSAGQLPTVRPGGVHTAATQTHPADGTAGALVTTTPCAREFADRGPIVR
                     LVASGFARVEPARMPRALVPAAQAALHAAGLKIDTMDAISTHNPFAVNDLYFARETGVT
                     LEAMNASGCSLLFGHPQGPTGLRTVTELAHVLKARGGGLGLFTGCAAGDTAAALIIEVT
                     D"
     gene            complement(7073..7798)
                     /gene="encK"
     CDS             complement(7073..7798)
                     /codon_start=1
                     /gene="encK"
                     /gene_functions="biosynthetic-additional (t2pks) MET
                     (Score: 89.7; E-value: 4.5e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative O-methyl transferase EncK"
                     /protein_id="AAF81726.1"
                     /transl_table=11
                     /translation="MTIDASPESSAFGFEGQSYYEHRRLRLYDAVVVHASNRLLWRCPK
                     SRLLEHYNDWITSRHLEVGPGSGYYLDHCRFPAGTPELTLLDLNPDPLKFAAHRLRRYT
                     PRCVQADILEPLPDFVGSGFTSIAYNYVMHCLPEPPGGKQIVFKHLREALAPDGVLFGS
                     TVLSQGVKHTALSRRFNILYQRQGSFHNQHDSVHGLHQALEEHFASHWIEVRGSVALFA
                     ARASQTTAPRHPGASLDQR"
     gene            complement(7826..8626)
                     /gene="encD"
     CDS             complement(7826..8626)
                     /NRPS_PKS="Domain: PKS_KR (9-182). E-value: 3.1e-12. Score:
                     38.6. Matches aSDomain: nrpspksdomains_encD_PKS_KR.1"
                     /codon_start=1
                     /gene="encD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     242.9; E-value: 5.7e-74)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 412.3; E-value: 1.7e-126)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative ketoreductase EncD"
                     /protein_id="AAF81727.1"
                     /sec_met_domain="adh_short (E-value: 3.5e-37, bitscore:
                     118.5, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPAHTESPSVALVTGGTSGIGLSIAQALLQDGLKVIITGRDPGKL
                     ETVVRSLKMEDDQFDVAGYTCDVRDRDAVHDMVERCAKEHGEPKVLVNNAGRSGGGVTA
                     AIPDELWLDVINTNLNSVFWVTREVIRSSDAIKQPAGRIINIASTGGKQGVPYGAPYSA
                     AKAGVIGFTKALAKEFAAHGGPTVNAVCPGYVETPMAQDIRASYAKLNNVTEEQVLADF
                     EAKIPLGRYCTPEEVAGMVRYLVSPAAASVTAQALNVCGGLGSY"
     aSDomain        complement(8081..8599)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encD_PKS_KR.1"
                     /evalue="3.10E-12"
                     /label="encD_PKS_KR.1"
                     /locus_tag="encD"
                     /protein_end="182"
                     /protein_start="9"
                     /score="38.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGGTSGIGLSIAQALLQDGLKVIITGRDPGKLETVVRSLKM
                     EDDQFDVAGYTCDVRDRDAVHDMVERCAKEHGEPKVLVNNAGRSGGGVTAAIPDELWLD
                     VINTNLNSVFWVTREVIRSSDAIKQPAGRIINIASTGGKQGVPYGAPYSAAKAGVIGFT
                     KALAKEFAAH"
     CDS_motif       complement(8507..8593)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encD_0001"
                     /evalue="2.40E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="encD"
                     /protein_end="40"
                     /protein_start="11"
                     /score="23.4"
                     /tool="antismash"
                     /translation="LVTGGTSGIGLSIAQALLQDGLKVIITGR"
     gene            8815..10086
                     /gene="encA"
     CDS             8815..10086
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-395). E-value:
                     1e-51. Score: 168.0. Matches aSDomain:
                     nrpspksdomains_encA_PKS_KS.1"
                     /codon_start=1
                     /gene="encA"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 456.9; E-value:
                     1.2e-138)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     719.9; E-value: 2e-219)"
                     /gene_kind="biosynthetic"
                     /product="putative keto synthase alpha EncA"
                     /protein_id="AAF81728.1"
                     /sec_met_domain="t2ks (E-value: 1.4e-230, bitscore: 755.8,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRHVVITGLSVLAPGSTDTEGFWKMITAGRSAIRRITAFDPTPF
                     RSQVAGEVDLDPLACGFSRREVRRLDRASLLAVACARRAVAEAGITSGTSIDPGRIGVS
                     VGNAVGSATSIENEYVVLSDEGRQWLVDQKYQSPHLFDYFVPGSLARETAWAAGAEGPV
                     SVISAGCTSGIDALGHACQLIQEGSADVMVAGATDAPVTPIAVACFDAIKATTRRNDDP
                     EHAPRPFDRTRDGFAIAEGAAMLVLEDSEHARRRGADIYGTITGYAAHSNAYHMTGLSR
                     DGNEMARAITTALDEARTDPTAVGYINAHGSGTKQNDLHETEAFKKALGEHAYNVPVSS
                     IKSMIGHSLGAIGAIEVATCALAIRNGVVPPTANLHEPDPDCDLDYVPLEARDVDLDVV
                     LTVGSGFGGFQSAMIVEKWRGGHV"
     aSDomain        8827..9999
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.00E-51"
                     /label="encA_PKS_KS.1"
                     /locus_tag="encA"
                     /protein_end="395"
                     /protein_start="4"
                     /score="168.0"
                     /tool="antismash"
                     /translation="VVITGLSVLAPGSTDTEGFWKMITAGRSAIRRITAFDPTPFRSQV
                     AGEVDLDPLACGFSRREVRRLDRASLLAVACARRAVAEAGITSGTSIDPGRIGVSVGNA
                     VGSATSIENEYVVLSDEGRQWLVDQKYQSPHLFDYFVPGSLARETAWAAGAEGPVSVIS
                     AGCTSGIDALGHACQLIQEGSADVMVAGATDAPVTPIAVACFDAIKATTRRNDDPEHAP
                     RPFDRTRDGFAIAEGAAMLVLEDSEHARRRGADIYGTITGYAAHSNAYHMTGLSRDGNE
                     MARAITTALDEARTDPTAVGYINAHGSGTKQNDLHETEAFKKALGEHAYNVPVSSIKSM
                     IGHSLGAIGAIEVATCALAIRNGVVPPTANLHEPDPDCDLDYVPLEARDVD"
     gene            10083..11306
                     /gene="encB"
     CDS             10083..11306
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (4-406). E-value:
                     2.4e-30. Score: 97.6. Matches aSDomain:
                     nrpspksdomains_encB_PKS_KS.1"
                     /codon_start=1
                     /gene="encB"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 632; E-value:
                     5.5e-192)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 7
                     (Score: 734.8; E-value: 5e-224)"
                     /gene_kind="biosynthetic"
                     /product="putative keto synthase beta EncB"
                     /protein_id="AAF81729.1"
                     /sec_met_domain="t2clf (E-value: 5.5e-206, bitscore: 674.2,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTDIVITGMGVTAPTGLSVKEYWNATLAGTQGIAPLQEFDPTPY
                     TARLAGQITGFEAKRHLPGRLLPQTDRVTRLALVAADRALEDAQVDVGELGTYECGVVT
                     SNATGGFEFSHREMQRLWTQGPDRVSVYQCFAWFYAVNTGQISIRHKMRGPGGVVVAEQ
                     AGGLDAIGHARRTITRGRSRLMVTGGVESSFDPWGWVSHLASGTVSTATDPATAYLPFD
                     QRACGYVPGEGGALLVMEDAQSARGRTDRRPYGKITGYAATFDPAPGAQRPSGLRRAVD
                     LALADAGLKPDAIDLVVADAAGVADLDAQEADALRAVFGPYGVPVCAPKTMVGRLMAGG
                     GPLDVVCALLALRDNVIPPAVNVTDVVDDYQIDLVRDEPRTCPLSRALVLARGAGGFNS
                     AVIVEHTP"
     aSDomain        10095..11300
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encB_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.40E-30"
                     /label="encB_PKS_KS.1"
                     /locus_tag="encB"
                     /protein_end="406"
                     /protein_start="4"
                     /score="97.6"
                     /tool="antismash"
                     /translation="IVITGMGVTAPTGLSVKEYWNATLAGTQGIAPLQEFDPTPYTARL
                     AGQITGFEAKRHLPGRLLPQTDRVTRLALVAADRALEDAQVDVGELGTYECGVVTSNAT
                     GGFEFSHREMQRLWTQGPDRVSVYQCFAWFYAVNTGQISIRHKMRGPGGVVVAEQAGGL
                     DAIGHARRTITRGRSRLMVTGGVESSFDPWGWVSHLASGTVSTATDPATAYLPFDQRAC
                     GYVPGEGGALLVMEDAQSARGRTDRRPYGKITGYAATFDPAPGAQRPSGLRRAVDLALA
                     DAGLKPDAIDLVVADAAGVADLDAQEADALRAVFGPYGVPVCAPKTMVGRLMAGGGPLD
                     VVCALLALRDNVIPPAVNVTDVVDDYQIDLVRDEPRTCPLSRALVLARGAGGFNSAVIV
                     EHT"
     CDS_motif       10743..10781
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encB_0001"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="encB"
                     /protein_end="233"
                     /protein_start="220"
                     /score="11.4"
                     /tool="antismash"
                     /translation="FDQRACGYVPGEG"
     gene            11354..11602
                     /gene="encC"
     CDS             11354..11602
                     /NRPS_PKS="Domain: ACP (9-76). E-value: 3.9e-14. Score:
                     44.6. Matches aSDomain: nrpspksdomains_encC_ACP.1"
                     /codon_start=1
                     /gene="encC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 86.8; E-value:
                     1.3e-26)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 89.9; E-value: 1.8e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl carrier protein EncC"
                     /protein_id="AAF81730.1"
                     /sec_met_domain="PP-binding (E-value: 5.5e-11, bitscore:
                     33.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSSDQLLQILSECSGDEQALAQGDDILDREFEVLGYDSLVLLET
                     SAQLKHRYDIDIPEDVIRDLKTPRAVLEYVNVPASRN"
     aSDomain        11381..11581
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encC_ACP.1"
                     /evalue="3.90E-14"
                     /label="encC_ACP.1"
                     /locus_tag="encC"
                     /protein_end="76"
                     /protein_start="9"
                     /score="44.6"
                     /tool="antismash"
                     /translation="ILSECSGDEQALAQGDDILDREFEVLGYDSLVLLETSAQLKHRYD
                     IDIPEDVIRDLKTPRAVLEYVN"
     gene            11655..12677
                     /gene="encL"
     CDS             11655..12677
                     /NRPS_PKS="Domain: PKS_AT (18-299). E-value: 1.3e-62.
                     Score: 203.7. Matches aSDomain:
                     nrpspksdomains_encL_PKS_AT.1"
                     /codon_start=1
                     /gene="encL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 229.1; E-value: 1.9e-69)"
                     /gene_functions="biosynthetic-additional (t2pks) AT (Score:
                     420.4; E-value: 1.2e-128)"
                     /gene_functions="biosynthetic-additional (t2pks) AT
                     AAF81731.1_Enterocin_benzoyl-CoA (Score: 679.0; E-value:
                     0)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl transferase EncL"
                     /protein_id="AAF81731.1"
                     /sec_met_domain="PKS_AT (E-value: 4.7e-63, bitscore: 203.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDAPTPHPCRPRPRVVLTFPGQGAQHARMAAGLYGVSKSFTSTMD
                     HAFDAFGPAGRTLREGWLAATPPAAFDDISYAQPLLYAVNCAMGAMVTEAGLRPDVLLG
                     HSVGELAAATLAGVFSFDCGLRYLSEYIGVYRHAPRGGMLAVAASPREVEAHLVPGVVI
                     GAVNAPRQVLLSAPEEALADVEAALRGAGITCSRARALQPFHHPVMRDVVTTYAGLLTR
                     PPLHPPHTTLYSAYTGQELANELATDWQFWTGQPAEPVLFGPTLEHLLSSGPHLLVEAG
                     PGQSLTALARRTPAVARGDAKALALLPARAGEPDADIEAVRAALKQLATCGCDPLSPDF
                     "
     CDS_motif       11700..11756
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encL_0001"
                     /evalue="1.70E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="encL"
                     /protein_end="34"
                     /protein_start="15"
                     /score="17.3"
                     /tool="antismash"
                     /translation="VLTFPGQGAQHARMAAGLY"
     aSDomain        11709..12551
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encL_PKS_AT.1"
                     /evalue="1.30E-62"
                     /label="encL_PKS_AT.1"
                     /locus_tag="encL"
                     /protein_end="299"
                     /protein_start="18"
                     /score="203.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="FPGQGAQHARMAAGLYGVSKSFTSTMDHAFDAFGPAGRTLREGWL
                     AATPPAAFDDISYAQPLLYAVNCAMGAMVTEAGLRPDVLLGHSVGELAAATLAGVFSFD
                     CGLRYLSEYIGVYRHAPRGGMLAVAASPREVEAHLVPGVVIGAVNAPRQVLLSAPEEAL
                     ADVEAALRGAGITCSRARALQPFHHPVMRDVVTTYAGLLTRPPLHPPHTTLYSAYTGQE
                     LANELATDWQFWTGQPAEPVLFGPTLEHLLSSGPHLLVEAGPGQSLTALARRTPAVARG
                     "
     CDS_motif       11940..12032
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encL_0002"
                     /evalue="1.30E-16"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="encL"
                     /protein_end="126"
                     /protein_start="95"
                     /score="52.6"
                     /tool="antismash"
                     /translation="GLRPDVLLGHSVGELAAATLAGVFSFDCGLR"
     gene            12734..14128
                     /gene="encM"
     CDS             12734..14128
                     /codon_start=1
                     /gene="encM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 421.2;
                     E-value: 1.2e-127)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 36.4; E-value: 7.4e-12)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative FAD-dependent oxygenase EncM"
                     /protein_id="AAF81732.1"
                     /transl_table=11
                     /translation="MQFPQLDPATLAAFSAAFRGELIWPSDADYDEARRIWNGTIDRRP
                     ALIARCTSTPDVVAAVSFARKSGLLVAVRGGGHSMAGHSVCDGGIVIDLSLMNSIKVSR
                     RLRRARAQGGCLLGAFDTATQAHMLATPAGVVSHTGLGGLVLGGGFGWLSRKYGLSIDN
                     LTSVEIVTADGGVLTASDTENPDLFWAVRGGGGNFGVVTAFEFDLHRVGPVRFASTYYS
                     LDEGPQVIRAWRDHMATAPDELTWALYLRLAPPLPELPADMHGKPVICAMSCWIGDPHE
                     GERQLESILHAGKPHGLTKATLPYRALQAYSFPGAVVPDRIYTKSGYLNELSDEATDTV
                     LEHAADIASPFTQLELLYLGGAVARVPDDATAYPNRQSPFVTNLAAAWMDPTEDARHTA
                     WAREGYRALAGHLSGGYVNFMNPGEADRTREAYGAAKFERLQGVKAKYDPTNLFRLNQN
                     IPPSSP"
     gene            14240..15808
                     /gene="encN"
     CDS             14240..15808
                     /NRPS_PKS="Domain: AMP-binding (20-415). E-value: 5e-92.
                     Score: 300.4. Matches aSDomain:
                     nrpspksdomains_encN_AMP-binding.1"
                     /codon_start=1
                     /gene="encN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     356.3; E-value: 3.6e-108)"
                     /gene_functions="biosynthetic-additional (t2pks) LIG
                     (Score: 680.2; E-value: 3.7e-207)"
                     /gene_functions="biosynthetic-additional (t2pks) LIG
                     AAF81733.1_Enterocin_benzoyl-CoA (Score: 1067.0; E-value:
                     0)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aryl-CoA ligase EncN"
                     /protein_id="AAF81733.1"
                     /sec_met_domain="AMP-binding (E-value: 2.2e-98, bitscore:
                     319.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTDLFNLSTLVDQHLDSGLSDKAALYSPHGHVSYGELYRSMCAM
                     GRALRELGIQREQRVLLILDDTPAFFTAFLGAGRIGAVPVPINYQTDPEQVRFYAQDSY
                     ARAAVIEAVRYEELAPALQEAGVMVISTEPAGPDDGRLHMRDLIRGHEGELGAASTHAE
                     DPALWLYSSGSTGRPKGVVHLQRDIAPACRHYAGDVLGVTQDDVHLSTTKLFHAYGLGN
                     SLLFPLWFGGTCVLLPGFPAPHLVLETIERVRPTLLFSVPALYNAMPRSPGAGSRDLSS
                     IRLCVSAAESLPAHVWERWRDLYGLTILDGVGSTEMLHIYCSNTERALRPGSSGRAVPG
                     YQIKLVDPDGGDVEGAGSGEMFVRGGSMLAQYWHRADQTRSVLKGSWYRTGDRYRRDED
                     GFYWYEGRADDMMKVSGLWVAPAAIETALQQHPDVAEAAVVGVDTDRLTRIKAFIVLRD
                     GCQGSDALARQLRQWCKDRLASHQFPHLVEFAADLPKTPTGKIQRFALRSQETVKADAP
                     AAHAV"
     aSDomain        14300..15484
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_encN_AMP-binding.1"
                     /evalue="5.00E-92"
                     /label="encN_AMP-binding.1"
                     /locus_tag="encN"
                     /protein_end="415"
                     /protein_start="20"
                     /score="300.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="SDKAALYSPHGHVSYGELYRSMCAMGRALRELGIQREQRVLLILD
                     DTPAFFTAFLGAGRIGAVPVPINYQTDPEQVRFYAQDSYARAAVIEAVRYEELAPALQE
                     AGVMVISTEPAGPDDGRLHMRDLIRGHEGELGAASTHAEDPALWLYSSGSTGRPKGVVH
                     LQRDIAPACRHYAGDVLGVTQDDVHLSTTKLFHAYGLGNSLLFPLWFGGTCVLLPGFPA
                     PHLVLETIERVRPTLLFSVPALYNAMPRSPGAGSRDLSSIRLCVSAAESLPAHVWERWR
                     DLYGLTILDGVGSTEMLHIYCSNTERALRPGSSGRAVPGYQIKLVDPDGGDVEGAGSGE
                     MFVRGGSMLAQYWHRADQTRSVLKGSWYRTGDRYRRDEDGFYWYEGRADDMMKVS"
     CDS_motif       14738..14788
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encN_0001"
                     /evalue="5.20E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="encN"
                     /protein_end="183"
                     /protein_start="166"
                     /score="19.1"
                     /tool="antismash"
                     /translation="LWLYSSGSTGRPKGVVH"
     CDS_motif       15452..15514
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_encN_0002"
                     /evalue="6.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="encN"
                     /protein_end="425"
                     /protein_start="404"
                     /score="12.5"
                     /tool="antismash"
                     /translation="EGRADDMMKVSGLWVAPAAIE"
     gene            complement(15850..16242)
                     /gene="encO"
     CDS             complement(15850..16242)
                     /codon_start=1
                     /gene="encO"
                     /product="EncO"
                     /protein_id="AAF81734.1"
                     /transl_table=11
                     /translation="MTTTLAEQAVTDFVREWSTAEERGEHRALDDLLAKDFVGVGPRGF
                     VRSREEWLARNSTGTVRNTSFEVSDLRIRSYGETAVVVAAQTQQSVNGDADASGAFRFT
                     LIVVRQDGRLRLAGLHLSPNAVPAGG"
     gene            complement(16269..17840)
                     /gene="encP"
     CDS             complement(16269..17840)
                     /codon_start=1
                     /gene="encP"
                     /product="putative phenylalanine ammonia lyase EncP"
                     /protein_id="AAF81735.1"
                     /transl_table=11
                     /translation="MTFVIELDMNVTLDQLEDAARQRTPVELSAPVRSRVRASRDVLVK
                     FVQDERVIYGVNTSMGGFVDHLVPVSQARQLQENLINAVATNVGAYLDDTTARTIMLSR
                     IVSLARGNSAITPANLDKLVAVLNAGIVPCIPEKGSLGTSGDLGPLAAIALVCAGQWKA
                     RYNGQIMPGRQALSEAGVEPMELSYKDGLALINGTSGMVGLGTMVLQAARRLVDRYLQV
                     SALSVEGLAGMTKPFDPRVHGVKPHRGQRQVASRLWEGLADSHLAVNELDTEQTLAGEM
                     GTVAKAGSLAIEDAYSIRCTPQILGPVVDVLDRIGATLQDELNSSNDNPIVLPEEAEVF
                     HNGHFHGQYVAMAMDHLNMALATVTNLANRRVDRFLDKSNSNGLPAFLCREDPGLRLGL
                     MGGQFMTASITAETRTLTIPMSVQSLTSTADFQDIVSFGFVAARRAREVLTNAAYVVAF
                     ELLCACQAVDIRGADKLSSFTRPLYERTRKIVPFFDRDETITDYVEKLAADLIAGEPVD
                     AAVAAH"
     gene            complement(18145..18390)
                     /gene="encQ"
     CDS             complement(18145..18390)
                     /codon_start=1
                     /gene="encQ"
                     /product="putative ferredoxin EncQ"
                     /protein_id="AAF81736.1"
                     /transl_table=11
                     /translation="MVTGESAAAGRWRLAVDATLCIGSGACAGSSAHFRMTQDGHAEPR
                     EDVIVADDTARDAAECCPVEAITVSDTSTGELIAPA"
     gene            complement(18384..19589)
                     /gene="encR"
     CDS             complement(18384..19589)
                     /codon_start=1
                     /gene="encR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 456.7; E-value:
                     1.1e-138)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative p450 monooxygenase EncR"
                     /protein_id="AAF81737.1"
                     /sec_met_domain="p450 (E-value: 2e-18, bitscore: 56.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGEA
                     WLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVAGV
                     FTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDDREQ
                     LRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDREEGL
                     LRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVEELLRF
                     IPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDIDRSPNPH
                     VAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVRGPKTLPV
                     KW"
     gene            complement(19682..20329)
                     /gene="encS"
     CDS             complement(19682..20329)
                     /codon_start=1
                     /gene="encS"
                     /gene_functions="regulatory (smcogs) SMCOG1057:TetR family
                     transcriptional regulator (Score: 130.6; E-value: 1.5e-39)"
                     /gene_kind="regulatory"
                     /product="putative regulatory protein EncS"
                     /protein_id="AAF81739.1"
                     /transl_table=11
                     /translation="MPKRVDHAQRRAHIADALVRVAARDGLHAVTMRAVAAEAGMSLNL
                     VQYYFDTKAQLMHAALQHLEQQSHERWSARLESLEDPGSARACLEAFVDEALPVDADSH
                     TFRLVWTSYAVLAMTDPELAEQPFVEGPNRLERQLTHILATAQAAGEIAAYLDVSAEAA
                     RLLSLSHGVGTSVLVGQRSAAQARYVMLYHLSRLFNDPTPPEAPGQHLAAAS"
     misc_feature    complement(19697..19699)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            20407..21855
                     /gene="encT"
     CDS             20407..21855
                     /codon_start=1
                     /gene="encT"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 399.8; E-value:
                     2e-121)"
                     /gene_kind="transport"
                     /product="putative efflux protein EncT"
                     /protein_id="AAF81738.1"
                     /transl_table=11
                     /translation="MGQREARAADGSVDTEKETGALVPRQAALLWLACAAQFMVVLDVS
                     VVNVALPSIQTALGFDAAGLQWVVGSYALVFAGFLLLGGRLADLYGRRRAFVWGLALFS
                     VSSLVGGLATGPGLLIAMRAVQGLGAAVLAPATLTILTTTFPEGPGRTKALAIWTAVSS
                     AGGAAGNLIGGVLTDALSWRWILLINVPIGTVAVLAALRLLPSDRSRAVSGRLDVPGAV
                     LATLGVTALVYGVNQAGTQGWTGATTLTGLAVSAVALTAFAVTESRYTAAPLLPPRLVR
                     LRPIWAGNVTMLLAGGCFIPMWYFLSLYMQEVLHYGALAAGVGFLPHTLVGIAAARLAP
                     AVMERTGARGLIVLSAVLSAVGFVWQSSISTDSGYLDGLLGPAIVMSAGMGLLITPITT
                     TVTSGIREQDAGAASGLMNTTRQLGGVVGLSALVTLATADGGPDLSYRAVFVATAAVCA
                     GVAVMALALPAPQEGRDESVAMQR"
     misc_feature    20494..20496
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
ORIGIN
        1 gccgacactc ccgcctcgga caaacgatca ccgatcgcct tcgaggacgc cctccactac
       61 accccaacta cgctggcaca agccgcataa cccgtgttca ggattcgggg tcaaggcccg
      121 aagtccagcc ggacccgttc gctctgatcg acccggagag ggctggcggt ggggtcgttc
      181 atgtcgaacc gcttgccgtc gatgccccag ttgtacctgt ccattccgcc ggtcagttcg
      241 atgcggtgga cgcggtcggt cttcttcgcc tccagccgta ccccgtccgc cgccttcagc
      301 tgagaggcag tcgtgatcgc gccgtccagt tcctccgggc ggaccgtggg ctcgggcgca
      361 ctgccggagc tggtgcggac cagggccatg ccgctggcgg tcttgccctc cgcgagcgcg
      421 accagcggga agacgccgtc ggcgagggtg accaggacgt gcggttcgcg cgtgcggaga
      481 atggcggggc ggtagagagg atccggggcg gtatggcgca agagcggcgc atgcagatcg
      541 gcgaggtcgc cgagcgcaca ggattgtcgt tgcgcacgat ccggcactac gaagaggtcg
      601 gcctcatcgt tccctccgcc cgcagcaagg gcggcttccc tctctacact caggccgacg
      661 tcagtcggct catggtgatt cggcgtatga agccgctgga tttctccctt gaggagatgc
      721 gggacctgct ggagatcact gacaggctcg gcgcccagga tgatccgccc gcacctgtgg
      781 agcgcgagcg actccgtgag cgacttgacg cgtaccgcaa ggtggccgac gcgcggtgcg
      841 agacactgcg cgcgcgactg gcgatggccg aggacttcgc cgccacgtgg cgtgacggga
      901 tgaatgcgga tgcccgagct cggtcggcaa gtgagcgggc tacttccggg ggccctctgc
      961 ggaggctctg gctcacgagt gatgcacccg gtcttgccgg gtagccatgc aggcgctcga
     1021 cgtggcagaa ggtgtgcgat tcgcggtcac agcgcgcaat ccgcgcaatg tggacacggt
     1081 gcatctggcc gtcgcatcgg taatcagaca agctgcgcca tactcctgac ccaacccgcc
     1141 gtcacggctc cccttgctgg caagtgcgga ggggcggcat acgcagtgag gcgctgacct
     1201 ggcccgacgc cgcttgctgg gagcggagcc aaaagcggac ctttccccga tcgagggcgt
     1261 ccggagggcc cgcgcgagac tcggcgggtg tgcgccgtcg gtgcgcggcg cacgtccgcg
     1321 atcacatgca gtcgcgcacc cagcgcagga aggggctcac gttgatactg gactctaccc
     1381 ttacaagggg gaagagatga ggaagcggtg cgatgtcaca ctctcgcgcg caggtgcgga
     1441 ggggctcccg ggtggggtgt cggcatagaa gcggtacgaa ggggcgcggt gtggccggtt
     1501 tcgcctcccg agcccttgac cctgcaatta ccgtgcggat acgttcagtc acatgcagag
     1561 gccatgcttt tgtgtcgtgc tgcggcaatg gcgcctcagt ggtcggtaat gcaagcgaat
     1621 tttcatgtgt cgcgcacagc cgcgcgaccc acacgtgtca actgactcag ggaattgcat
     1681 gcgaaatcgc ctcactgccc gctgcccgct gtgcggtaaa tgcaaacagt caacggggtg
     1741 aaagaacggt ggacgtcgaa gttctcgggc atgtgacgct gaaggtcggc gatgagcgcc
     1801 ggacaccgag cgcccccaag gccaggcagg tccttgccct cctgctggtc aacgcaaaca
     1861 gaatggtcag caccgatgtt ctgatcgaag aactgtgggc cgagcagcct cctcggagcg
     1921 cgctcagtgc gttgcagacg tacgtgttcc agctgcggca gctgttgagg aagatccgtc
     1981 cagatgaatg ccctaagcag ctcctggtga ccacgccgaa cggctatgaa ttccgcgtcc
     2041 cgccggagaa cgtggacctg caacgctacg aacggcatcg cctggccggc cagcaagcct
     2101 ttcaatcggg cgagaacatg gctgctgtcg agcagttccg cgccgctctg catatctttg
     2161 cggcgccgcc tctggcgaat gtccggcgtg ggatgcatct tgaggctgag atcgtcaggc
     2221 tggaagagag ccgtatcggg gtccaggaaa ccagaatcga agcggaactc gaactggggc
     2281 gtcatcatga ggtgctgagc gagctgagcg gactggcgtc gcagtgtccg cagcatgaag
     2341 gattccaccg tcaactgatg ctcgcactct accgttgcgg cagacgtccg caggcgctga
     2401 aggtgttcaa ccagctgcgg cagtccctcg tgaccgagtt gggactggag ccctcccggg
     2461 agctgcagat gttgcagcag gcgattctgt ccgcggaccc tcggctggac accgctgagc
     2521 ggaccccgtt cctgcgcacg accgctgatc cggctcctct gcaggtcccg tggccggcgg
     2581 ccagcccctg gaaggtgtga ggcggcgcag cggtggctga gtgcggagcc gctgcgttgt
     2641 gccagccgag ggttgttggg acgttgtcgt ctcacctctt ggggagatcg tcccggaaga
     2701 cctggcggtg ccggatgaac catcggccct cgttccggac gagcacgtcc tcgcaggtac
     2761 acacgaactc cagctccgac cggcctccca ccaccgtctt ggtgatcagg gcgtaggtct
     2821 tggccaggag cgtcagtcca ctcgcctgct ggagttccag ggtggtgacg cagtggcggc
     2881 gcaggatgcc cttctcctgc agctgccgcg ctgcggcctc cgcgtttcgg gcgatctcgg
     2941 cccgcccgcg ctggggctcg ggtcgggcgt tggtcgcgaa gaccgcgtcg ggcatgaagt
     3001 cgccggtcca gtcctccact cggccttcgt ccatggcccg catgtggcgc ccgtagaact
     3061 gctgaatctc tgcgaacaac gccgcggtct cctccggctt gtgcggggcc tgtgtcaagg
     3121 cgctctcctc tgcttgggtc gggtcagctc ctgccgtagt cacggtgagg gctgcttctc
     3181 catgcccggt aaagagacaa gctcggccag ggcaagtcgc gagagcagcc cgtgacgctg
     3241 tcttgcttcc ccctcaaggt gccggtggtg cgctgtccag tggagaccgg tggcaagggc
     3301 caccgcctga tgcgacggag gccacaagca tggaaccggc ccctcaggcc cccacacaac
     3361 ctgtgatcga cgctcggcgc cccgaagcgg gaccgcgttg ggagaccatc ggcgagctca
     3421 tcaaagatgc cgcgttgctg cacggcgaca aggaattcct ccgatgcggc gacaagacgc
     3481 tcagcttctc cgagaccgac acccgcaccg accggttggc gcaggcgctg atcgcccaag
     3541 gtgtcaaacc gggtgaccgt gtcgcggtca tgatggacaa cgtggcggac tggccgttga
     3601 gctggttcgc ggccatcaag gccggtgcca tcacggtgcc ggtcaacacc cgcttcggcg
     3661 ctacggacct cgcgcacgtc ctgaaggact ctcaggccgt gcgggtcctg gcctccccag
     3721 gctgcgtgcc tttggcccgt gacgtgagcg gcagcatcgg gcacccctgt gcggtccgga
     3781 cgctacgcga actggaggcc gacttcggcg accggccggt ggacggtccg ggcctgtcgg
     3841 cgcacgcgga cgacaccgtc aacttccagt acacctccgg caccacaggc tttccgaaag
     3901 cctgcatgct cagccacgac tactggctgc gcacggcgtg gatgatcgct gtccactccg
     3961 gcctccgtcc cgacgacgtc gtgctgacgg cccaggcgtt ctcctacatg gatccccagt
     4021 ggaaagccgt gatgtgcctg atgggcggcg ttccgctggt ggtgctcccg cggttctccg
     4081 cctccggctt ctggcactcc gtccgccagc accgggccac gctgacctac gtgctgggca
     4141 gcatgcccat gctgctgtac aagcagccgc cccactcggg cgaccgcgat catgcgatgc
     4201 ggctggtctt gtgctcgggc atcccgcgcg acttgcacca tgcgttcgag gaccgctggg
     4261 gtgcggcctg gcgggaggtg tacggctcca ccgagagcgg actggacttg atcatgccgc
     4321 ctggtgagga ggccaccgtg ggcagcggcg cgatggggta cccgccgtcc ggcaaggagg
     4381 tcatcgtcgc cgacgagcgc caacgccccg tccagccagg gcagatcggc gagatcctgg
     4441 tgcggggaag gcccatgatg aaaggctact ggaacaaccc ggacagtacc gagcgggcgt
     4501 tccgcggcgg ctggtaccac accggtgacc tcggacgtgc cgaggcggcc gggagcgtgg
     4561 tgcacgccgg gcggctgaag gacatgatcc gacgcggtgg ggagaacatc gcagcggccg
     4621 aagtcgagag cgtcctcgaa gcccacccgg cggtcctggc cgccgcgctc gccggcatcc
     4681 ccgacgagct cttcggtgag ctgcccaaag ccttcctgca gctgcgcccc ggctaccggc
     4741 ccaccacggc aacggctcgc agcgtcctcg cgcacacccg ccgccacctc gcgaaattca
     4801 aggtccctgc ctatgtcgaa ttcgtcgact ccttccccat gaccccctcc gcccgtatcc
     4861 agaagcgcca gctgcttcgt cccggagacg accagcgcac cggtgcgttc gacgccgcag
     4921 cggatgcatg ggcatgagcg acgtacagca gttgctgagc tccgccgacc tgaccgtcac
     4981 ggtcgacagc gatgttgctg tgatcgcgat gagccgtccg gcgaaactca acgccctgac
     5041 ccgcggcatg cgccgggacc tggccgagct gctgcgccac tacggcgacg gcagccaggc
     5101 tcgcggagtg gtgatcaccg gccaggcaaa agccttctct gccggaatgg acctgcgcga
     5161 agtcgccggc ccggaagtcg acttgctggc ggagatggag ctgttcaacg acatcacccg
     5221 cgccgctctc atcacggaag tcccggtcgt ggccgccctc aacggcatcg ccgtcggcgg
     5281 cgccggtgag atggccctga gcttcgacgc ccgcatcgcc accgctcagg ccgcgatctc
     5341 atggccggag acaggtgtcg ggctcaccgt gtccaatgcc gcgagcctgt tcctgccccg
     5401 cctcgctggc gcaccccgag ccctgcacct gatcatgaac agtgcccggc tcagcgcctc
     5461 ccaggcactg gccctcggtc tcctcgacga catcgtcgag ccggacgatc tcatccccgc
     5521 cgccatccgg ctgatccacc agtggacgcc gccgggttcg tccacggccg cacatctgag
     5581 gctgatgcgg ccctcgctgc gtgcggtaga agcggccatg gcacgcgagg gcgcggccgt
     5641 acggcaggtc caggagagcg gcattgccca ggccggcatc gccacggtgc tggctggcca
     5701 cgaaaagtga cctttgctgc tgcgggccgg ggccgtaccc cgaagggggc cgccgaggca
     5761 caaaccgaac gggctgtggt gaaggccgaa agcctccttc accacagccc gctgggtgtc
     5821 cctgtctgcc cagcactggg caccaggagg ccgggtcagt cggtcacttc gatgatcagt
     5881 gctgccgcgg tgtcccctgc ggcgcacccg gtgaacagtc ccagccctcc gcctcgtgcc
     5941 ttcagtacgt gtgcgagttc cgtgaccgtc cgcagcccgg tcgggccttg ggggtgtccg
     6001 aagaggaggc tgcagccgga cgcgttcatg gcctccagcg tcaccccggt ttcccgggcg
     6061 aagtacaggt cgttcaccgc gaaggggttg tgggtgctga tggcatccat cgtgtcgatc
     6121 ttcagcccgg cggcgtgcag cgccgcctgc gcggccggaa cgagtgccct gggcatgcgc
     6181 gccggctcca cgcgggcgaa tccggatgcg accaggcgca cgatcgggcc gcggtcggcg
     6241 aattcccggg cgcacggtgt cgtggtcacc agggcccccg ctgtgccgtc ggcgggatgc
     6301 gtttgcgtgg cggcggtgtg gacgccgccg gggcggaccg tcgggagttg accggcgctg
     6361 tcggccgtga ccggccgcac gccttcgtcg gacaagagcc gtacggtgcc gagcccgtcc
     6421 tgttcgatct cgatgccgac catgaagtca cgctggaagg tgcggtcgtc gctgagcgcg
     6481 gcggtgtact gctcggagcg caggacggcg agggcatcca ggtcgtcgcg ggtgaagccg
     6541 cactcggccg cgacggcttc ggctgtggcg agcatgctct gtccggtgac ggggtcctgg
     6601 gagaagctgt cgcgtaccca gttctcgcgc accggtccct gctcggaacc ggcgggtgag
     6661 ggccaggaga ggtccgggcc gttgctggtg cggtcggtgg tgacgatcag ttgtgggccg
     6721 actcctgttc ctactgccgc ggcggcctgg tgcagggccg cgacggaggt ggcgcaggct
     6781 tggttgagca tcggtccgga gacctggggc atgcccagtc gggccgcgag cgtggtggct
     6841 ccgtagaaga tggcgggctg cggcacggtc cagcccagca ccatgccctc gatggtgtcg
     6901 cggtcgatgc cgcgctccga cagtgcccgg ccggtggcgg ccacggccag gtcgaggctg
     6961 gagaggtggg acagggcgcc tccccaccgc gcgaagggcg aggtccacag cgccgtcagg
     7021 ggaatggccg catcacggta ggtggccccg gacgtcatgc gcttctcctc actcatcgct
     7081 ggtccaggga tgctccgggg tggcggggcg cggtggtctg cgatgcgcgg gccgcgaaga
     7141 gtgcgacgct gccgcgtacc tcgatccagt ggctggcgaa gtgttcctcc agggcctggt
     7201 gcagtccgtg gacgctgtca tgctggttgt ggaaggagcc ctggcgctgg tagaggatgt
     7261 tgaagcggcg ggagagggcg gtgtgtttca cgccctggga caggacggtg ctgccgaaga
     7321 ggacgccgtc gggcgcgagt gcctcgcgca ggtgcttgaa gacgatctgc ttgccgcccg
     7381 gtggctcggg caggcagtgc atgacgtagt tgtaggcgat ggatgtgaat ccgctgccga
     7441 cgaagtcggg caagggttcc aggatgtccg cctgcacgca gcgcggggtg tagcggcgca
     7501 ggcggtgcgc ggcgaacttg agcgggtcgg ggttgaggtc gagcagggtc agctcgggtg
     7561 tgcctgcggg gaagcggcag tggtccaggt agtagcccga gccggggccg acctccaggt
     7621 ggcgggaggt gatccagtcg ttgtagtgct cgagcagccg tgacttcggg cagcgccaca
     7681 gcagccggtt cgacgcatgg acgaccacgg cgtcatacag gcgcagccgc cggtgttcgt
     7741 agtaggactg gccctcgaag ccgaaggcgg aggactcggg ggatgcatcg atggtcatgc
     7801 gcgtgtccct cttccactcg aagcgtcagt aactgcccag tccgccgcag acgttgagtg
     7861 cctgggcggt caccgacgcg gctgccgggc tgaccaggta gcgcaccatg cccgccacct
     7921 cctcgggggt gcagtagcgg ccgaggggga ttttggcctc gaagtcggcg aggacctgct
     7981 cctcggtgac gttgttgagc ttggcgtaac tggcgcggat gtcctgggcc atgggcgttt
     8041 ccacgtagcc ggggcatacc gcgttcacgg tggggccgcc gtgggcggcg aattccttgg
     8101 cgagtgcctt ggtgaagccg atgacaccgg ccttggccgc cgagtacggg gccccgtacg
     8161 ggacgccctg cttgccgccg gtggacgcga tgttgatgat ccggccggct ggctgcttga
     8221 tcgcgtcgct gctccggatg acctcgcggg tcacccagaa gacgctgttg aggttggtgt
     8281 tgatgacgtc cagccacaac tcgtcgggga tcgcggcggt cacgccgccg ccgctgcggc
     8341 cggcgttgtt gaccaggacc ttcggctcgc cgtgctcctt ggcgcaccgt tccaccatgt
     8401 cgtgcaccgc gtcgcggtct cgtacgtcgc aggtgtaacc ggccacgtcg aactggtcgt
     8461 cctccatctt cagcgacctg acgacggtct ccagcttccc ggggtcgcgg ccggtgatga
     8521 tgaccttcag cccatcctgc agcagggcct gggcgatcga cagaccaatg ccgctggtgc
     8581 cgcctgtgac cagagcgacg cttggggact cggtgtgtgc gggcatggtg agactttctc
     8641 ccttcgtcgg ggcggccgga acgggccggc ccgacgacga ggctccctgc tggcggtgca
     8701 gggccggtcc acgcccgggc aaggcgctct ctgccgccca agcaaggcgc tctggagcag
     8761 aggatgagcg gcggtggact gccgctggag cagcaccccg caaggtctca aggtgtgagc
     8821 cgacacgtag tcataactgg cctgagcgtc ctcgcacccg gttcgacgga tacagagggc
     8881 ttctggaaga tgatcacagc ggggcgcagc gcgatccgca ggatcacggc attcgacccc
     8941 acgccgttcc gttcccaggt ggcgggagag gtcgatctcg atccgctggc ctgtgggttc
     9001 agccgccgcg aggtccggcg tctggaccgg gccagcctgc tggccgtggc ctgcgccaga
     9061 cgggcggtgg cggaagccgg gatcacctcc ggtacgagta tcgaccctgg ccgcatcggt
     9121 gtgagcgtgg gcaacgcggt gggatccgcc acaagtatcg agaacgagta cgtcgtgctg
     9181 tccgacgagg gacgccagtg gctggtcgac cagaagtacc agtcccccca cctgttcgac
     9241 tacttcgtcc cgggttccct cgcccgcgag accgcctggg cggccggtgc cgaaggaccg
     9301 gtgtcggtca tctcggccgg ctgcacctct ggcatcgacg ccctcggcca tgcctgccag
     9361 ctcatccagg agggcagtgc cgacgtgatg gtcgccggcg ccaccgatgc tcccgtcacc
     9421 ccgatcgcgg tggcctgctt cgatgcgatc aaggccacca cgcgccgtaa cgacgatccc
     9481 gaacacgcgc cgcggccctt cgaccgcacc cgggacggat tcgccatcgc cgagggcgcg
     9541 gccatgctgg tcctggagga cagcgaacac gcccggcggc gcggagccga catttacggc
     9601 accatcaccg gatacgccgc gcactcgaac gcgtaccaca tgacgggcct gtcccgggac
     9661 ggcaatgaga tggcccgcgc catcacgacc gccctggacg aggcccgcac cgaccccacg
     9721 gccgtcgggt acatcaacgc ccacggctct ggcacgaaac agaacgacct gcatgaaacc
     9781 gaggcgttca agaaggccct gggcgagcac gcttacaacg tcccggtcag ctccatcaag
     9841 tcgatgatcg ggcattccct gggcgcgatc ggcgcgatcg aggttgcaac ctgcgcgctg
     9901 gccatccgca acggagtggt gccccccacc gcgaacctcc atgagcccga cccggactgc
     9961 gacctggact acgtccccct tgaggcgcgt gatgtggacc ttgacgtcgt cctgaccgtg
    10021 ggcagcgggt tcggggggtt ccagagcgcc atgatcgtgg agaagtggcg aggaggccac
    10081 gtatgagcac cgatatcgtg atcaccggga tgggtgtgac cgcgcctacc ggcctgagcg
    10141 tcaaggagta ctggaacgcc accctggccg gcacccaggg catcgccccg ctgcaggagt
    10201 tcgatcccac gccgtacacg gcgcggctgg ccgggcagat caccggcttc gaggccaaga
    10261 ggcacctgcc cgggcggctg ctgccgcaga ccgaccgcgt cacccggctc gccctggtcg
    10321 ccgccgaccg cgcgcttgag gacgcccagg tcgacgtcgg cgaactcggc acctacgagt
    10381 gcggtgtcgt cacctcgaac gcgaccggcg gcttcgagtt ctcccaccgc gagatgcagc
    10441 ggctgtggac gcagggcccc gatcgcgtca gcgtctacca gtgcttcgcc tggttctacg
    10501 ccgtcaacac cggccagatc tccatccggc acaagatgcg tggcccgggc ggcgtggtcg
    10561 tcgccgaaca ggcaggcggc ctcgatgcga tcgggcacgc ccgccgcacg atcacccgcg
    10621 gccgcagccg cctgatggtc accggcggcg tcgagtcctc cttcgaccca tggggctggg
    10681 tgtcccacct ggcctccggc accgtcagca cggccaccga ccccgccacc gcctacctgc
    10741 cgttcgacca gcgggcctgc ggctatgtgc cgggagaagg cggtgccctc ctcgtcatgg
    10801 aggacgccca atcggcgcgc ggacgcaccg accggcgtcc ctacggaaag atcaccggct
    10861 acgcggcgac cttcgacccc gcccccggag cgcagcggcc ctccggtctg cggcgcgccg
    10921 tggacctggc tctggcggat gcggggctta agcccgacgc catcgacctc gtcgtcgccg
    10981 acgcggcagg cgtcgccgac ctcgacgccc aggaagccga tgccctgcgg gccgtcttcg
    11041 gcccgtacgg cgtccccgtc tgtgcgccca agaccatggt cggtcgcctg atggccggcg
    11101 gagggccact cgatgtggtg tgcgccctgc tcgcgctgcg cgacaacgtc atcccaccgg
    11161 ccgtcaacgt caccgacgtc gtcgacgact accagatcga cctcgtccgt gacgagccac
    11221 gcacgtgccc cctgtcgagg gccctcgtcc tcgcgcgcgg cgccggcggc ttcaactcgg
    11281 ccgtcatcgt cgagcacacc ccctgaaacc tccactccct gtgttcccac ccattgagaa
    11341 gggaccgttc cgcatgctca gcagcgacca gctcctgcag atcctcagcg agtgctccgg
    11401 cgacgagcag gccctcgccc agggcgacga catcctcgac cgcgagttcg aggtcctcgg
    11461 ctacgactcc ctggtcctgc tggagacctc cgcccagctc aagcaccgct acgacatcga
    11521 catcccggag gacgtcatcc gggacctgaa gacaccgcgc gccgtcctgg agtacgtcaa
    11581 cgtccccgcc agcaggaact gaggcatccg tccgcccgcc tcccgcccct tttttgcacc
    11641 gcaggagcca gctgatggat gcccccaccc cacacccctg tcggccgcgc cccagagtcg
    11701 ttctcacctt ccccggccaa ggggcacagc acgcccgcat ggccgccggc ctctacggcg
    11761 tctccaagtc cttcacctcc acgatggacc acgccttcga cgccttcgga ccggcgggac
    11821 gcacactgcg cgaaggatgg ctcgcggcca caccacccgc ggccttcgac gacatctcct
    11881 atgcccagcc cctgctgtac gcggtcaact gcgcgatggg cgccatggtc accgaggccg
    11941 gtctgcgccc cgacgtcctg ctgggccaca gtgtggggga actggccgcc gccaccctgg
    12001 ccggcgtgtt ctccttcgac tgcggcctgc gctacctgtc cgaatacatc ggcgtctacc
    12061 ggcacgcccc gcgcggcggc atgcttgccg tggccgccag ccccagggag gtcgaagccc
    12121 acctggtgcc gggcgtggtc atcggcgccg tcaacgcacc gcgccaggtt ctgctctccg
    12181 ccccggaaga ggccctggcc gacgtggaag ccgccctccg tggtgccggt atcacctgtt
    12241 cccgcgcccg cgccctgcag cccttccacc acccggtgat gcgcgacgtc gtcacgacct
    12301 acgcgggctt gctcacccgt ccgcccctcc acccgcctca caccaccctc tactccgcct
    12361 acaccgggca ggaacttgcc aacgagctcg ccaccgactg gcagttctgg accggtcagc
    12421 ccgccgagcc ggtcctgttc ggccccaccc tggagcatct gctgagcagt ggccctcacc
    12481 tcttggtcga ggcaggccct ggacagagcc tgaccgccct ggcacggcgc acgcccgcgg
    12541 ttgcccgcgg tgacgcgaag gccctcgccc tgctgccggc ccgcgcgggc gagccggacg
    12601 ccgatatcga agccgtacgg gccgccctga agcaactcgc cacctgcgga tgcgacccgc
    12661 tgtctccgga cttctgaccc ctcgccgcca gccccgtcaa gcgcccgtcg tggcgccgca
    12721 gaaagggacc agcatgcagt tcccacagct cgaccctgcc accctggccg cgttcagcgc
    12781 ggcgttccgg ggggagttga tctggccgag cgacgccgac tacgacgagg cgcgccgcat
    12841 ctggaacggc acgatcgacc ggcgccccgc gctgatcgcc cgctgcacca gcaccccgga
    12901 cgtggtcgct gcggtgagct tcgcccgcaa gagcggcctg ctggtcgcgg tccgcggcgg
    12961 cggacacagc atggccgggc actcggtatg cgacggcggg atcgtcatcg atctctcctt
    13021 gatgaacagc atcaaggtca gccgccgcct gcggcgcgcg cgagcccagg gcggctgcct
    13081 gctgggggcg ttcgacaccg ccacacaggc ccacatgctc gccacccccg ccggcgtggt
    13141 ctcccacacc ggattggggg gactcgtcct cggcggcgga ttcggctggc tgagccgcaa
    13201 gtacggcctg tccatcgaca acctcacctc cgtggagatc gttaccgcgg acggcggcgt
    13261 cctcactgcg agcgacaccg agaaccccga cctgttctgg gccgtccgcg gcggcggcgg
    13321 caacttcggt gtggtgaccg cattcgagtt cgacctccac cgggtcgggc ccgtccgttt
    13381 cgccagcacc tactactcgc tggacgaagg accccaggtc atccgggcct ggcgcgacca
    13441 tatggccacc gcccccgacg aactgacctg ggcgttgtat ctgcgcctgg caccgccgct
    13501 gcccgaactg cccgccgaca tgcacggcaa gccggtgatc tgcgccatga gctgctggat
    13561 cggggacccg cacgagggtg agcggcagct tgagtccatc cttcacgccg gcaagcccca
    13621 cggtctgacc aaggcgactt tgccctaccg ggccctgcag gcgtactcct ttcccggcgc
    13681 cgtcgtcccc gaccggatct acaccaagag cggctatctg aacgaactga gcgatgaagc
    13741 caccgacacg gtcctggaac acgccgccga catcgcctcc cccttcactc agctcgaact
    13801 gctctacctg ggcggggccg tggcgcgcgt gcccgacgac gccaccgcct accccaaccg
    13861 ccagtcgccg ttcgtgacca acctggccgc cgcctggatg gaccccaccg aggacgcccg
    13921 ccacaccgcc tgggcccgcg agggctaccg ggccctggcc ggccacttgt ccggcggcta
    13981 cgtcaacttc atgaacccgg gcgaggcgga ccgcacgcgg gaggcttacg gggccgccaa
    14041 gttcgaacgg ttgcagggcg tcaaggccaa gtacgacccg acgaatctgt tccgcctcaa
    14101 ccagaacata cccccgagca gcccctgacc cacaccacgc ccccacccag ctctgccccg
    14161 gctcccggcc aatgccgcga ccggggcagg gtcacacccg ggggccgatc agctccatgc
    14221 ctctcgaaca ggagccgaca tgaccaccga cctcttcaac ctctccaccc tggtcgacca
    14281 gcatctcgac agcggcctga gcgacaaggc cgccctctac agcccccacg gccacgtcag
    14341 ctacggcgag ctgtaccgga gcatgtgtgc gatgggccgg gctctgcgtg agcttggcat
    14401 ccagcgcgaa cagcgcgtcc tgctcatcct ggacgacacc ccggcgttct tcaccgcctt
    14461 cctcggcgcc ggccgcatcg gcgctgtccc ggtcccgatc aactaccaaa ccgaccctga
    14521 acaggtgcgt ttctacgccc aggacagtta cgcccgggcg gctgtgatcg aggcggtccg
    14581 gtacgaggag ctcgcgcccg ctctgcagga ggccggcgtg atggtgatca gcaccgagcc
    14641 cgcagggccg gacgacggca ggctccacat gcgcgacctg atccgcggcc acgagggcga
    14701 gctgggcgcc gcgtccacac acgccgagga tcccgcgctg tggctgtaca gctccgggtc
    14761 caccggacgg cccaaagggg tggttcacct gcagcgggac atcgcacccg cctgccggca
    14821 ctacgcgggc gatgtcctgg gtgtcactca ggacgacgtg cacctgtcca ccaccaagct
    14881 cttccacgcc tacggcctgg gcaacagcct gctgtttccg ctgtggttcg gcgggacatg
    14941 cgtcctgctg cccgggtttc cggcaccgca cctcgtgctg gagaccatcg aacgagtacg
    15001 tcccacgctg ctgttctccg tcccggcctt gtacaacgcc atgccccgct cgcccggcgc
    15061 cggctctcgg gacctgtcgt ccatccggct gtgcgtctcg gccgccgaga gcctgcccgc
    15121 ccacgtctgg gaacgatggc gcgaccttta cgggctgacg atcctggacg gtgtggggtc
    15181 caccgaaatg ctgcacatct actgcagcaa caccgagcgg gcgcttcgcc ccggctcctc
    15241 cgggagggcc gtgcccggct accagatcaa gctcgtcgac cccgacggcg gcgatgtgga
    15301 aggcgcgggc agcggagaga tgttcgtgcg gggcggcagc atgctggccc agtactggca
    15361 ccgtgccgac cagacccgct cggtgttgaa ggggagctgg taccgcaccg gcgaccgcta
    15421 ccgccgcgac gaggacggct tctactggta cgagggacgt gccgacgaca tgatgaaggt
    15481 ctccgggctg tgggtcgctc ccgccgcgat cgagaccgcc cttcagcagc acccggatgt
    15541 tgccgaggca gcggtcgtcg gcgtggacac cgaccgcctc acccggatca aggcgttcat
    15601 cgtgctgcgc gacggttgcc agggcagcga cgcactggcc cggcagctgc ggcagtggtg
    15661 caaggaccgt ctggccagtc atcagtttcc gcacctggtc gagttcgccg cggacctgcc
    15721 caagacgcct acgggcaaga tccagcggtt cgccctgcgc tcacaggaga cggtaaaggc
    15781 ggatgctccg gccgcccacg ccgtgtgacc agcgcgggcg gccggagccg acgccgtccc
    15841 ggcaggggct cagccgcctg ccgggacggc gttcgggctc aggtgcaggc cggcgagccg
    15901 cagccgcccg tcctggcgga cgacgatgag cgtgaagcgg aacgcaccac tggcgtcggc
    15961 atcaccgttc acgctctgct gggtctgggc cgccaccacg accgccgtct ccccgtagga
    16021 gcggatacgc aggtcgctca cctcaaacga cgtgttgcgc acggtgcccg tgctgttgcg
    16081 ggccagccac tcctcgcggc tgcgcacgaa gccccggggc ccgacgccga cgaagtcctt
    16141 cgcgagcagg tcgtccagcg ccctgtgctc tccccgctct tcggccgtgc tccattcccg
    16201 gacgaagtcc gtaaccgcct gctcggccag cgtggtcgtc atggtgtgtc tcccttccag
    16261 gtgctgcttc agtgcgccgc cacggcagcg tcgacgggct cgcccgcgat caggtcggcc
    16321 gccagcttct cgacgtagtc ggtgatggtc tcgtcccggt cgaagaacgg cacgatcttg
    16381 cgggtgcgct catagagcgg gcgggtgaag gaggacagtt tgtccgcgcc gcggatgtcg
    16441 acggcctggc aggcgcacag cagctcgaag gccaccacgt aggcagcgtt ggtgagtacc
    16501 tcccgggcgc ggcgggcggc gacgaatccg aaggacacga tgtcctggaa gtccgccgta
    16561 ctcgtgaggg actgcaccga catcggaatg gtcagggtgc gggtctccgc ggtgatcgac
    16621 gcggtcatga actggccgcc catcaggccc aggcgcagtc ccggatcttc ccggcacagg
    16681 aaggcgggca gcccgttgct gttgctcttg tccaggaagc ggtccacgcg ccggttggcg
    16741 agattggtca cggtggccag ggccatgttc aggtggtcca tggccatggc cacgtactgg
    16801 ccgtggaagt gcccgttgtg gaacacctcc gcctcctccg gcaggacgat cgggttgtcg
    16861 ttggaggagt tcagctcgtc ctgcagggtc gccccgatcc ggtccagcac atcgaccacg
    16921 ggaccgagga tctgcggcgt gcaccggatg gagtaggcgt cctcgatcgc cagcgaaccg
    16981 gccttggcga ccgtgcccat ctctccggcc agggtctgct cggtgtccag ttcgttgacc
    17041 gccaggtgcg agtcggcaag cccctcccac aaccgcgagg ccacctgacg ctgcccgcgg
    17101 tgcggcttga cgccgtgcac gcgagggtcg aacggtttcg tcatgcctgc caggccctcg
    17161 accgacaacg cggacacctg caggtagcgg tccacgagcc ggcgcgcggc ctggaggacc
    17221 atggtgccca ggccgaccat gcctgacgtg ccgttgatca gggccaggcc atccttgtag
    17281 ctcagctcca tcggctcgac gccggcctcg gacagggcct gccgcccggg catgatctga
    17341 ccgttgtagc gggccttcca ctgccccgcg cacaccaggg cgatcgcggc cagcgggccg
    17401 aggtcaccgc tggtgcccaa agagcccttc tccgggatgc acggcacgat cccggcgttg
    17461 agtacggcca ccagcttgtc cagattcgcc ggggtgatcg cggagttccc gcgcgccagc
    17521 gacacgatgc gggacagcat gatggtccgg gcggtcgtgt cgtccagata cgcccccacg
    17581 ttggtggcga ccgcgttgat caggttctcc tggagctgcc gggcctggga caccgggacg
    17641 aggtggtcga cgaagccccc catgctggtg ttgaccccgt agatgacacg ttcgtcctgc
    17701 acgaacttca ccaacacgtc gcgcgaggcg cggacgcggg agcggacggg tgcggacagc
    17761 tccacgggcg tgcgctgtcg cgccgcgtcc tcaagttggt cgagcgtgac gttcatgtcg
    17821 agctctatga cgaaggtcat gaagttccct ttgcggccgg agaatcggtg gactcgacgg
    17881 gttgtacaga ccgtctgccc atgccagcgg acaggcgcgg cacgccgacg gccatccgga
    17941 tcgcgaccgg gcaggccggc tgagtgacgc accgaattca ctgaagcgcc cgtcactcca
    18001 cgcccaagca aggcagcctc atggcccgcc caaggtcacc ccctgagccc ctcggcgctc
    18061 ccccgcgagg cggcccgtag tcgacaggcg gttcctccat ggccacaggg gatgtgatgc
    18121 tgaagtggcg acatgccccg cggctcacgc cggtgcgatc aactcgccgg tactggtgtc
    18181 ggacaccgtg atggcctcca ccgggcaaca ctccgcggcg tcccgtgccg tgtcatcggc
    18241 gacgatgacg tcctcgcgcg gctcggcgtg gccgtcctgc gtcatccgga aatgggcaga
    18301 ggaaccggca cacgcacccg atccgatgca caacgtcgcg tccaccgcca gccgccaacg
    18361 gcctgcagcc gcagactccc cggtcaccac ttcaccggca gggtcttcgg cccacgtacc
    18421 tgcatgcccg tcttccacac gatctccgct tcgtcgacag ccagtcgcag ccgcggcaga
    18481 cggcgcagca ggacgcccag cgccacctgg agctccagcc tggccaactg cgcacccagg
    18541 cagtggtgca caccgtgccc gaaggcgacg tgcgggttgg gggacctgtc gatatcgagg
    18601 cggcccggct cagcaaagac gtccggatcc cagttggccg ccacagtggg ggcgaacacg
    18661 gtgtcaccgg gctggatcct caccccgcac agttccaccg gctcggtggc gaccctggcc
    18721 cggaaactgc ccgagcccag cgggatgaac cgcagcagct cctccactgc ggacgccatc
    18781 gccgagggat ccgtgcgcaa gcggtccatg tcatgcgggc gctggagcag caggtaggtg
    18841 cagttggcga tctggctcgc cgtggtctca tggccggcga tgagcagatc acgggtgaga
    18901 aggaccagct cctcgtcgcg aagcagcccc tcctcccggt cccacgtctg caccagagcc
    18961 ccgagcaggt catcggtcgg ctggcggcgc cgctggctca ccagggcggc gaagtggtcg
    19021 gccatggcct gcgcggccgc cgccgattca gctggagtgc aggccgtggt ggacagcagc
    19081 gcatcggacc agccccgcaa ctgttcacgg tcgtccccgg gtacacccag caggtcgcag
    19141 atcaccgtga cgggcagcgg cagtgcatag gatgcgacca gatcggccgg tgcacccgag
    19201 gcttccatcg cctccagcaa ctcctcggcg atcctctgcg tggcgggccg cagatcttcc
    19261 accctgcgct tggtgaagac acccgcgacc gttttacgca gccgcgtgtg gtccggggga
    19321 tccagcgaca tcagcacgcc ttcacccgcc gggtcaggct ggatccgcgg cgcctgggcg
    19381 tgctgcgtgg cggcacgact gaaccgcggg tcgcccagca cggtcttgat gtcctgataa
    19441 cgcgtgacca gccatgcctc acccccgtac gggaggcgga cgcgactgat gggctcctct
    19501 tcgcgcaatt gcgcgaaggc cggttccatg tgcagctcgg cggggggcgc gaagggaaag
    19561 tcccgcaact gctgggtatg ggtggtcact gagcttctcc tgtccgtcaa gcggggcagt
    19621 ccactcgcga gccctgccgc acatcgcacg gcggggagtc ccgtttccga gccggcacca
    19681 gtcaggaagc tgccgctaag tgctggccag gggcctcggg tggagtgggg tcgttgaaca
    19741 agcgggagag gtggtagagc atcacgtacc gggcttgtgc cgccgaccgc tgcccgacca
    19801 gcacgctggt cccgacaccg tgactgaggc tcagcagacg cgcggcctcg gcggagacat
    19861 ccagataagc cgcgatctct cccgccgcct gcgccgtggc caggatgtgg gtgagctgtc
    19921 gctcaagccg gttcggcccc tcgacgaagg gctgctccgc cagctcgggg tcggtcatgg
    19981 ccagtaccgc gtaggacgtc cacaccagcc ggaaggtgtg gctgtccgcg tcgaccggca
    20041 gggcttcatc cacgaacgct tcgagacagg cccgtgccga ccccggatcc tccaggctct
    20101 ccagccgcgc cgaccaccgc tcgtggctct gctgctcaag gtgctgcaga gcggcgtgca
    20161 tcaactgggc cttggtgtcg aagtagtact gcaccaggtt caaggacatg cccgcctcgg
    20221 ccgcgaccgc gcgcatggtc accgcatgca gtccgtcccg cgcggccacc cggaccaggg
    20281 cgtcagcgat gtgcgcccgg cgctgggcat ggtcaacacg tttcggcacc gtgacccctt
    20341 cccgttcgac ccgttttcat agtaccgctg tactataaaa gctggccgcg acgatgggga
    20401 agagacatgg gacaacgcga agcccgtgcc gccgacggat cagtcgacac cgagaaagaa
    20461 acaggcgcac tggtgccccg tcaggcggcg ctgttatggc tggcctgcgc ggcacagttc
    20521 atggtggtgc tcgacgtgtc ggtggtgaac gtcgcgctgc cgtcgatcca gaccgcgctc
    20581 ggcttcgacg cggcgggact gcagtgggtc gtgggcagct acgcgctggt cttcgcgggt
    20641 ttcctgcttc tcggcggtcg gctcgcggac ctgtacggcc gacgtcgggc gttcgtgtgg
    20701 gggctggcgc tgttctccgt ctccagcctg gtgggcggac tcgccaccgg ccccggcctg
    20761 ctgatcgcca tgcgggcggt gcagggcctg ggcgccgcgg tgctggcccc ggccacgctg
    20821 accatcctga ccaccacctt ccccgaaggg ccgggccgca ccaaggcgtt ggcgatctgg
    20881 actgcagtca gctccgccgg aggcgcggcg ggcaacctga tcggcggcgt cctgaccgac
    20941 gcactgtcct ggcggtggat cctgctgatc aacgtgccga tcggcaccgt ggccgtcctg
    21001 gcggccctgc gtctgctgcc gtccgaccgc tcccgcgcgg tatccggcag gctcgacgtc
    21061 cccggggcgg tgctggccac cctcggcgtc accgcactcg tctacggcgt caaccaggcc
    21121 gggacacagg gctggacagg ggcgaccacc ctgacgggcc tggcggtcag cgccgtggcg
    21181 ctgaccgcgt tcgcggtgac ggagagccgg tacacggcgg cccccctatt gccgccccgc
    21241 ctggtgcggc tgcgcccgat ctgggccggc aacgtcacca tgctgctggc gggcggctgc
    21301 ttcatcccta tgtggtactt cctgtcgctg tacatgcagg aggtcctcca ctacggggcc
    21361 ttggccgcgg gcgtcggttt cctgccccac acgcttgtcg gtatcgcggc tgcccgcctc
    21421 gccccggccg tcatggagcg caccggcgcc cgcggcctca tcgttctcag cgccgtcctc
    21481 agcgccgtcg gctttgtctg gcagagcagc atcagcacgg acagcggcta cctggacgga
    21541 ctgctcgggc ccgcgatcgt catgtccgcc ggcatgggac tgctcatcac cccgatcact
    21601 accaccgtca cctccggcat ccgcgagcag gatgcggggg cagcctccgg gctgatgaac
    21661 accacccgcc agctcggcgg tgtcgtcggg ctctctgccc tcgtcaccct cgctaccgcc
    21721 gacggcggtc cggacctgtc gtacagggcg gtgttcgtgg cgacggcggc tgtgtgcgcg
    21781 ggcgttgcgg tgatggcctt ggcgctgcct gcgccacaag agggccggga cgagtccgtc
    21841 gcgatgcagc ggtgagtttc cgtgccggcc tccggtaagg aggtgctggt ctgccctcgt
    21901 caggtgtcac gctgtgatca ttcaccgacg ggagtccggc gcgggtcttc tcgttccggc
    21961 tctgcgatgt cggccgactg gtccggttcc ctcagccgga acagcgcggc gaggatgccc
    22021 gcggtgccgc tggcggcgaa cagtgcaccc gtggcgatcg aggtcgagtc gatcagcggc
    22081 ccgaagagca gaggcgaggc gaactggccg ccgaagagcg cggtcgcctg caacgaggtg
    22141 gcggtgccgc gctgttcggc gggggcggcg cggtcgacca ggacggtcag ggtgggcatc
    22201 gtgatgccgc tgccgatccc ggtgagcacc ggcacgatca gcagcacggc ccagtgcccg
    22261 gcgacggtaa agaccagcag cgccgccgtc cacgcttcgg ccgcgatccg catcaacgcg
    22321 gcatagccaa ggtgggcggt gagcttggca taggtgaggc cgaccaggct cgcggcgccg
    22381 gaggtgaagc acggtgccgt acagacagtg aggcttcctt ttgcctgcgc cacgccctga
    22441 cgctcacggg ctcaatgccg ggagggcacc ctgcatgtgt tccgcgcatt tccaaggatc
    22501 attgaaattc c
//
