Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000220.1:
Cluster 1Polyketide122511

BGC0000220, enterocin biosynthetic gene cluster from Streptomyces maritimus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Enterocin
SMILES string: Copy to clipboard
Molecular formula: C22H20O10
Exact molecular mass: 444.105647 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Benzoyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
A,A,F,8,1,7,2,8,.,1
Genes involved in folding/cyclization:
ENCM

Gene cluster description

enterocin (BGC0000220). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF254925. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression, Proven expression in natural host
MIxS-compliance:Unknown
Contact for this cluster:Robin Teufel (Scripps Institution of Oceanography; UCSD)

Literature references

1. Teufel R et al. (2013) Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature 503(7477):552-556. doi: 10.1038/nature12643. Epub 2013 Oct
2. Cheng Q et al. (2007) Enzymatic total synthesis of enterocin polyketides. Nat Chem Biol 3(9):557-8. doi: 10.1038/nchembio.2007.22. Epub 2007 Aug
3. Piel J et al. (2000) Cloning, sequencing and analysis of the enterocin biosynthesis gene cluster from the marine isolate 'Streptomyces maritimus': evidence for the derailment of an aromatic polyketide synthase. Chem Biol 7(12):943-55.
4. Miyairi N et al. (1976) Enterocin, a new antibiotic taxonomy, isolation and characterization. J Antibiot (Tokyo) 29(3):227-35.