BGC0000222 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000222 (Streptomyces sp. TA-0256)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	43,026	FD-594	PKS	100%

BGC0000222 - Region 1 - T2PKS

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Location: 1 - 43,026 nt. (total: 43,026 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,027
Label		BGC0000222

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000222	1.00	Polyketide	FD-594	Streptomyces sp. TA-0256
BGC0002435	0.34	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001893	0.33	Other	abscisic acid	Botrytis cinerea B05.10
BGC0002631	0.33	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001757	0.33	Other	rhabduscin	Xenorhabdus nematophila ATCC 19061
BGC0000844	0.32	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002031	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000275	0.30	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001928	0.29	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002218	0.29	Terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000222	1.00	Polyketide	FD-594	Streptomyces sp. TA-0256
BGC0002435	0.67	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001893	0.67	Other	abscisic acid	Botrytis cinerea B05.10
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0001757	0.66	Other	rhabduscin	Xenorhabdus nematophila ATCC 19061
BGC0000844	0.65	Other	clavulanic acid	Streptomyces clavuligerus
BGC0002031	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0000275	0.64	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001928	0.63	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0002218	0.62	Terpene	(-)-Cyatha-3,12-diene	Dentipellis sp. KUC8613

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

pnxJ

PKS_AT (14..294): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.0
Methoxymalonyl-CoA: 36.4
Methylmalonyl-CoA: 34.1
inactive: 27.6
fatty_acid: 22.3
Isobutyryl-CoA: 13.3
Propionyl-CoA: 12.7
2-Methylbutyryl-CoA: 10.3
Ethylmalonyl-CoA: 9.8
Benzoyl-CoA: 8.3
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 43026
Starter unit(s):: butyryl-CoA (Score: 1302.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 689.6; E-value: 2.5e-210)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: butyryl-CoA_11: 882 Da
butyryl-CoA_12: 924 Da

pnxA: KS (Score: 730.4; E-value: 1.3e-222)
pnxB: CLF 11|12 (Score: 689.6; E-value: 2.5e-210)
pnxC: ACP (Score: 114.9; E-value: 3e-36)
pnxD: CYC C9-C14 (Score: 246.5; E-value: 1.8e-76)
pnxG: KR C19 (Score: 433.5; E-value: 5.3e-133)
pnxGT1: GT (Score: 292.7; E-value: 1.3e-89)
pnxGT2: GT (Score: 407.3; E-value: 2e-124)
pnxJ: AT (Score: 413.6; E-value: 1.4e-126); AT BAJ52678.1_FD-594_butyryl-CoA (Score: 643.0; E-value: 0.0)
pnxK: CYC C4-C21/C2-C23|C2-C19 (Score: 170.9; E-value: 1.4e-53)
pnxL: CYC C5-C18 (Score: 225.3; E-value: 4.2e-70)
pnxMT1: MET (Score: 46.9; E-value: 4.6e-15)
pnxO1: KR (Score: 104.4; E-value: 1.8e-32)
pnxO4: OXY (Score: 296.4; E-value: 1e-90)
pnxO6: OXY (Score: 250.9; E-value: 6.3e-77)
pnxU: KSIII (Score: 427.6; E-value: 7.6e-131); KSIII BAJ52704.1_FD-594_butyryl-CoA (Score: 659.0; E-value: 0.0)
pnxV: ACP (Score: 73.1; E-value: 3.2e-23)
pnxW: KR C11 (Score: 423.8; E-value: 4.4e-130)