BGC0000223 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000223 (uncultured bacterium BAC AB649/1850)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	66,898	High	rabelomycin/dehydrorabelomycin/fluostatin F/fluostatin G/fluostatin H	PKS:Type II

BGC0000223 - Region 1 - T2PKS

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Location: 1 - 66,898 nt. (total: 66,898 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 66,899
Label		BGC0000223

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

AEE65462.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AEE65463.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AEE65465.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AEE65473.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AEE65478.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AEE65483.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

AEE65484.1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

AEE65502.1: oxidoreductase

smcogs: SMCOG1161: oxidoreductase

AEE65522.1: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: acetyltransferase carboxylase methyltransferase transferase

AEE65461.1: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

AEE65470.1: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

AEE65480.1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

AEE65503.1: Chloramphenicol acetyltransferase

smcogs: SMCOG1156: Chloramphenicol acetyltransferase

Hydrolases: amidase hydrolase

AEE65481.1: alpha/beta hydrolase fold protein

smcogs: SMCOG1036: alpha/beta hydrolase fold protein

AEE65490.1: amidase

smcogs: SMCOG1105: amidase

AEE65521.1: HAD-superfamily hydrolase, subfamily IA, variant

smcogs: SMCOG1115: HAD-superfamily hydrolase, subfamily IA, variant

Lyases: cyclase hydratase lyase

AEE65464.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

AEE65469.1: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

AEE65487.1: Nitrilase/cyanide hydratase and apolipoprotein

smcogs: SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein

AEE65489.1: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: synthase

AEE65467.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

AEE65468.1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

AEE65482.1: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs: SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000223.5	0.94	PKS	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0000234.5	0.83	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001904.2	0.81	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002047.2	0.60	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.59	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002369.2	0.58	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0002672.2	0.58	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000223.5	1.00	PKS	rabelomycin, dehydrorabelomycin, fluostatin F, fluostatin G, fluostatin H	uncultured bacterium BAC AB649/1850
BGC0000234.5	0.83	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.82	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001904.2	0.81	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000272.3	0.60	PKS	spore pigment	Streptomyces collinus
BGC0002047.2	0.60	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002369.2	0.59	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0002672.2	0.59	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 47958
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 699.6; E-value: 2.4e-213)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 446 Da
acetyl-CoA_9: 488 Da

AEE65462.1: OXY (Score: 569.4; E-value: 1.5e-173)
AEE65463.1: OXY (Score: 538.7; E-value: 3.2e-164)
AEE65464.1: CYC C7-C12 (Score: 485.1; E-value: 1.6e-148)
AEE65465.1: KR C9 (Score: 463.1; E-value: 5.4e-142)
AEE65466.1: ACP (Score: 111.5; E-value: 3.3e-35)
AEE65467.1: CLF 8|9 (Score: 699.6; E-value: 2.4e-213)
AEE65468.1: KS (Score: 780.0; E-value: 1.2e-237)
AEE65469.1: CYC C4-C17/C2-C19 (Score: 193.7; E-value: 6.8e-60)
AEE65473.1: OXY (Score: 524.3; E-value: 7.1e-160)
AEE65477.1: DIMER (Score: 286.0; E-value: 7e-88)
AEE65478.1: OXY (Score: 454.8; E-value: 8.5e-139)
AEE65479.1: OXY (Score: 55.1; E-value: 1.5e-17)
AEE65480.1: MET (Score: 295.0; E-value: 1.7e-90)
AEE65483.1: KR (Score: 149.0; E-value: 4.7e-46)
AEE65484.1: OXY (Score: 518.1; E-value: 5.6e-158)