Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000223.1:
Cluster 1Polyketide166898

BGC0000223, fluostatin biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Rabelomycin
PubChem ID: 443810
SMILES string: Copy to clipboard
Molecular formula: C19H14O6
Average molecular mass: 338.315 Da
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AEE65468.1
Genes involved in folding/cyclization:
AEE65464.1, AEE65469.1

Gene cluster description

fluostatin (BGC0000223). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank HM193369, positions 1-66760. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sean Brady (The Rockefeller Univeristy)

Literature references

1. Feng Z et al. (2010) Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. J Am Chem Soc 132(34):11902-3. doi: 10.1021/ja104550p.