BGC0000223: rabelomycin biosynthetic gene cluster from uncultured bacterium BAC AB649/1850
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Location: 1 - 66,898 nt. (total: 66,898 nt).
This entry is originally from NCBI GenBank HM193369.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000223
Short description rabelomycin biosynthetic gene cluster from uncultured bacterium BAC AB649/1850
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
HM193369.1
via Heterologous expression
Compounds
  • rabelomycin
  • dehydrorabelomycin
  • fluostatin F
  • fluostatin G
  • fluostatin H
Species uncultured bacterium BAC AB649/1850 [taxonomy]
References
Chemical products information
rabelomycin Evidence:
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C19H14O6
Chemical database entries
NPAtlas
PubCHEM
dehydrorabelomycin Evidence:
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C19H12O5
Chemical database entries
PubCHEM
fluostatin F Evidence:
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C19H14O6
Chemical database entries
NPAtlas
PubCHEM
fluostatin G Evidence:
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C24H22O7
fluostatin H Evidence:
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C24H22O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEE65458.1
 614 - 1570 (-) beta-lactamase domain protein
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    • AEE65459.1
    		 1680 - 2564 (-) bata-lactamase
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      • AEE65460.1
      		 2601 - 3557 (+) transcriptional regulater
      • Regulation
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      • AEE65461.1
      		 3794 - 5467 (-) carboxyl transferase
      • Tailoring
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      • AEE65462.1
      		 5440 - 6888 (-) oxygenase
      • Tailoring
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      • AEE65463.1
      		 6885 - 8390 (-) Oxygenase reductase-like protein
      • Tailoring
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      • AEE65464.1
      		 8387 - 9337 (-) aromatase
      • Scaffold biosynthesis
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      • AEE65465.1
      		 9361 - 10143 (-) ketoreductase
      • Tailoring
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      • AEE65466.1
      		 10156 - 10431 (-) acyl carrier protein
      • Scaffold biosynthesis
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      • AEE65467.1
      		 10428 - 11690 (-) chain length determinant
      • Scaffold biosynthesis
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      • AEE65468.1
      		 11687 - 12958 (-) ketoacyl synthase
      • Scaffold biosynthesis
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      • AEE65469.1
      		 12955 - 13284 (-) putative polyketide cyclase
      • Scaffold biosynthesis
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      • AEE65470.1
      		 13307 - 15043 (-) carboxylase, alpha subunit
      • Tailoring
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      • AEE65471.1
      		 15219 - 15905 (-) two component regulater
      • Regulation
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      • AEE65472.1
      		 16178 - 16579 (+) oxidase-related FMN-binding protein
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        • AEE65473.1
        		 16708 - 18198 (+) oxygenase-like protein
        • Tailoring
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        • AEE65474.1
        		 18230 - 18943 (+) oxidase-like protein
        • Tailoring
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        • AEE65475.1
        		 18982 - 19521 (+) hypothetical protein
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          • AEE65476.1
          		 19584 - 20678 (+) hypothetical protein
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            • AEE65477.1
            		 20742 - 21503 (-) NAD-dependent epimerase/dehydratase
            • Tailoring
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            • AEE65478.1
            		 21583 - 23058 (-) putative oxygenase
            • Tailoring
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            • AEE65479.1
            		 23303 - 24526 (-) oxidoreductase
            • Tailoring
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            • AEE65480.1
            		 24532 - 25539 (-) putative O-methyltransferase
            • Tailoring
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            • AEE65481.1
            		 25792 - 26571 (+) hypothetical protein
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              • AEE65522.1
              		 27526 - 28497 (-) alcohol dehydrogenase
              • Tailoring
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              • AEE65482.1
              		 28497 - 29531 (-) 3-oxoacyl-(acyl carrier protein) synthase III
              • Scaffold biosynthesis
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              • AEE65483.1
              		 29557 - 30282 (-) short-chain dehydrogenase/reductase SDR
              • Tailoring
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              • AEE65484.1
              		 30279 - 31766 (-) monooxygenase
              • Tailoring
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              • AEE65485.1
              		 31810 - 32802 (-) streptomycin biosynthesis operon regulator
              • Regulation
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              • AEE65486.1
              		 33136 - 34338 (+) Nitric-oxide synthase
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                • AEE65487.1
                		 34343 - 35182 (+) amidohydrolase-like protein
                • Tailoring
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                • AEE65488.1
                		 35234 - 35635 (-) GCN5-related N-acetyltransferase
                • Tailoring
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                • AEE65489.1
                		 35632 - 36906 (-) adenylosuccinate lyase
                • Tailoring
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                • AEE65490.1
                		 37062 - 38558 (+) amidase
                • Tailoring
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                • AEE65491.1
                		 38558 - 40063 (+) glutamine synthetase
                • Precursor biosynthesis
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                • AEE65492.1
                		 40142 - 40501 (+) putative ferredoxin
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                  • AEE65493.1
                  		 40498 - 42384 (+) hypothetical protein
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                    • AEE65494.1
                    		 42374 - 43063 (-) response regulator
                    • Regulation
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                    • AEE65495.1
                    		 43647 - 43910 (+) Hypothetical protein
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                      • AEE65496.1
                      		 44467 - 46689 (-) PAS/PAC sensor signal transduction histidine kinase
                      • Regulation
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                      • AEE65497.1
                      		 46815 - 47255 (+) ShdA
                      • Transport
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                      • AEE65498.1
                      		 47504 - 48412 (+) antitoxin component
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                        • AEE65499.1
                        		 48468 - 48659 (+) putative regulatory protein
                        • Regulation
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                        • AEE65500.1
                        		 48916 - 49116 (+) putative regulatory protein
                        • Regulation
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                        • AEE65501.1
                        		 49176 - 49718 (+) conserved hypothetical protein
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                          • AEE65502.1
                          		 49751 - 50869 (-) geranylgeranyl reductase
                          • Tailoring
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                          • AEE65503.1
                          		 50949 - 51494 (+) galactoside O-acetyltransferase
                          • Tailoring
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                          • AEE65504.1
                          		 51491 - 52057 (+) transcriptional regulator, TetR family
                          • Regulation
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                          • AEE65505.1
                          		 52054 - 53262 (+) putative DeoR-type transcriptional regulator
                          • Regulation
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                          • AEE65506.1
                          		 53273 - 53719 (-) hypothetical protein
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                            • AEE65507.1
                            		 53718 - 54041 (+) AGR369Wp
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                              • AEE65508.1
                              		 54188 - 54628 (+) hypothetical protein
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                                • AEE65509.1
                                		 54701 - 55240 (+) intracellular protease
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                                  • AEE65510.1
                                  		 55266 - 56552 (-) integral membrane protein
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                                    • AEE65511.1
                                    		 56591 - 57010 (-) NUDIX hydrolase
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                                      • AEE65512.1
                                      		 57122 - 58060 (-) Ku protein
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                                        • AEE65513.1
                                        		 58153 - 59100 (+) DNA polymerase LigD ligase region
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                                          • AEE65514.1
                                          		 59093 - 60001 (+) DNA polymerase LigD, polymerase domain protein
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                                            • AEE65515.1
                                            		 60063 - 60851 (+) hypothetical protein
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                                              • AEE65516.1
                                              		 60934 - 61275 (+) transcriptional regulator, PadR-like family
                                              • Regulation
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                                              • AEE65517.1
                                              		 61272 - 61697 (+) hypothetical protein
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                                                • AEE65518.1
                                                		 61694 - 63355 (-) helicase domain protein
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                                                  • AEE65519.1
                                                  		 63393 - 65792 (-) hypothetical protein
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                                                    • AEE65520.1
                                                    		 65874 - 66107 (+) hypothetical protein
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                                                      • AEE65521.1
                                                      		 66104 - 66760 (+) hypothetical protein
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                                                        Biosynthesis information
                                                        Annotation changelog

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Removed gene names of 'No gene ID'
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2019-10-16
                                                        Updated compound(s) information (NPAtlas curation)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: V5OJFE3GCDVKSA62LSGPW5E6)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        Detailed domain annotation
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