BGC0000224: fredericamycin A biosynthetic gene cluster from Streptomyces griseus
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Location: 1 - 33,064 nt. (total: 33,064 nt).
This entry is originally from NCBI GenBank AF525490.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000224
Short description fredericamycin A biosynthetic gene cluster from Streptomyces griseus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
AF525490.2
via Knock-out studies, Enzymatic assays
Compounds
  • fredericamycin A
Species Streptomyces griseus [taxonomy]
References
Chemical products information
fredericamycin A Evidence:
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C30H21N1O9
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAQ08909.1
 33 - 1631 (-) putative acyl CoA decarboxylase
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    • AAQ08910.1
    		 1727 - 2770 (+) putative acyl transferase
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      • AAQ08911.1
      		 2731 - 4920 (-) putative multicopper oxidase
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        • AAQ08912.1
        		 4971 - 5771 (+) putative 3-ketoacyl-ACP reductase
        • Tailoring
        • Other in vivo study
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        • AAQ08913.1
        		 5782 - 7263 (+) putative peptide transporter
        • Transport
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        • AAQ08914.1
        		 7420 - 7740 (+) putative polyketide cyclase
        • Scaffold biosynthesis
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        • AAQ08915.1
        		 7804 - 8229 (+) putative polyketide cyclase
        • Scaffold biosynthesis
        • Other in vivo study
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        • AAQ08916.1
        		 8226 - 9491 (+) 3-ketoacyl-ACP synthase
        • Scaffold biosynthesis
        • Activity assay
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        • AAQ08917.1
        		 9488 - 10699 (+) chain length factor
        • Scaffold biosynthesis
        • Activity assay
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        • AAQ08918.1
        		 10764 - 11018 (+) ACP
        • Scaffold biosynthesis
        • Activity assay
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        • AAQ08919.1
        		 11020 - 11487 (+) putative polyketide cyclase
        • Scaffold biosynthesis
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        • AAQ08920.1
        		 11484 - 11807 (+) putative monooxygenase
        • Tailoring
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        • AAQ08921.1
        		 11825 - 12259 (+) putative oxygenase
        • Tailoring
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        • AAQ08922.1
        		 12333 - 13073 (-) putative monooxygenase
        • Tailoring
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        • AAQ08923.1
        		 13111 - 13560 (-) putative monooxygenase
        • Tailoring
        • Knock-out
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        • AAQ08924.1
        		 13801 - 14265 (+) putative monooxygenase
        • Tailoring
        • Knock-out
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        • AAQ08925.1
        		 14322 - 15383 (+) putative o-methyltransferase
        • Tailoring
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        • AAQ08926.1
        		 15497 - 16246 (+) putative 3-ketoacyl-ACP reductase
        • Tailoring
        • Other in vivo study
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        • AAQ08927.1
        		 16248 - 16559 (+) putative monooxygenase
        • Tailoring
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        • AAQ08928.1
        		 16559 - 16876 (+) putative monooxygenase
        • Tailoring
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        • AAQ08929.1
        		 17040 - 18041 (-) putative 3-keto-acyl-ACP synthase
        • Scaffold biosynthesis
        • Other in vivo study
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        • AAQ08930.1
        		 18122 - 19153 (-) putative membrane transporter
        • Transport
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        • AAQ08931.2
        		 19310 - 19741 (-) transcriptional regulator
        • Regulation
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        • AAQ08932.2
        		 19943 - 20368 (+) Unknown
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          • AAQ08933.1
          		 20468 - 22336 (+) asparagine synthetase
          • Tailoring
          • Activity assay Knock-out
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          • AAQ08934.1
          		 22401 - 24236 (-) regulatory protein
          • Regulation
          • Knock-out Other in vivo study
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          • AAQ08935.1
          		 24472 - 26067 (+) putative membrane transporter
          • Transport
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          • AAQ08936.1
          		 26150 - 26629 (+) holo-ACP synthase
          • Scaffold biosynthesis
          • Activity assay Knock-out
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          • AAQ08937.1
          		 26869 - 27381 (+) transcriptional regulator
          • Regulation
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          • AAQ08938.1
          		 27689 - 28906 (+) transposase
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            • AAQ08939.1
            		 28988 - 30565 (+) putative membrane transporter
            • Transport
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            • AAQ08940.1
            		 30621 - 31229 (-) unknown
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              • AAQ08941.1
              		 31226 - 32515 (-) unknown
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                Biosynthesis information
                Annotation changelog

                Entry version: 3

                Date
                Changes
                Submitters
                Reviewers
                2022-10-07
                Update chemical activity to schema version 2.11
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 2

                Date
                Changes
                Submitters
                Reviewers
                2019-10-16
                Migrated from v1.4
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                2019-10-16
                Updated compound(s) information (NPAtlas curation)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                Entry version: 1

                Date
                Changes
                Submitters
                Reviewers
                2015-06-12
                Submitted
                • (ID: HPZ6LL7T2WJIC44FKRYGWFQ6)
                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                Detailed domain annotation
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