BGC0000224 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000224 (Streptomyces griseus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	33,064	fredericamycin A	PKS:Type II	100%

BGC0000224 - Region 1 - T2PKS

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Location: 1 - 33,064 nt. (total: 33,064 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,065
Label		BGC0000224

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000224	1.00	Polyketide	fredericamycin A	Streptomyces griseus
BGC0000190	0.55	Polyketide	A-74528	Streptomyces sp. SANK 61196
BGC0001928	0.35	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000885	0.31	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000231	0.30	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000846	0.28	Other	tabtoxin	Pseudomonas syringae
BGC0000888	0.28	Other	bacilysin	Bacillus sp. CS93
BGC0001184	0.28	Other	bacilysin	Bacillus velezensis FZB42
BGC0001444	0.27	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000275	0.27	Polyketide	tetracenomycin C	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000224	1.00	Polyketide	fredericamycin A	Streptomyces griseus
BGC0000190	0.82	Polyketide	A-74528	Streptomyces sp. SANK 61196
BGC0001928	0.68	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0000885	0.65	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000231	0.64	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000846	0.62	Other	tabtoxin	Pseudomonas syringae
BGC0000888	0.61	Other	bacilysin	Bacillus sp. CS93
BGC0001184	0.61	Other	bacilysin	Bacillus velezensis FZB42
BGC0001444	0.61	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000275	0.61	Polyketide	tetracenomycin C	Streptomyces glaucescens

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

AAQ08910.1

PKS_AT (11..294): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 44.7
Methylmalonyl-CoA: 39.8
Methoxymalonyl-CoA: 39.4
fatty_acid: 18.1
inactive: 17.2
Ethylmalonyl-CoA: 14.8
Propionyl-CoA: 10.9
Benzoyl-CoA: 9.8
3-Methylbutyryl-CoA: 7.5
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8

Type II PKS gene cluster prediction details

Cluster section:: 0 to 33064
Starter unit(s):: hexadienyl-CoA (Score: 1322.0; E-value: 0)
malonamyl-CoA (Score: 561.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 714.4; E-value: 7.3e-218)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: hexadienyl-CoA_11: 512 Da
hexadienyl-CoA_12: 554 Da
malonamyl-CoA_11: 503 Da
malonamyl-CoA_12: 545 Da

AAQ08910.1: AT (Score: 422.9; E-value: 2.1e-129); AT AAQ08910.1_Fredericamycin_hexadienyl-CoA (Score: 664.0; E-value: 0.0)
AAQ08912.1: KR (Score: 232.0; E-value: 2.1e-71)
AAQ08914.1: CYC C4-C21/C2-C23|C2-C19 (Score: 173.1; E-value: 3e-54)
AAQ08915.1: CYC C5-C18 (Score: 212.3; E-value: 4.3e-66)
AAQ08916.1: KS (Score: 732.9; E-value: 2.3e-223)
AAQ08917.1: CLF 11|12 (Score: 714.4; E-value: 7.3e-218)
AAQ08918.1: ACP (Score: 99.5; E-value: 1.9e-31)
AAQ08919.1: CYC C9-C14 (Score: 251.1; E-value: 7.1e-78)
AAQ08925.1: MET C11O (Score: 552.4; E-value: 7.6e-169)
AAQ08926.1: KR C19 (Score: 431.3; E-value: 2.4e-132)
AAQ08929.1: KSIII (Score: 429.9; E-value: 1.5e-131); KSIII AAQ08929.1_Fredericamycin_hexadienyl-CoA (Score: 658.0; E-value: 0.0)
AAQ08933.1: AMID (Score: 779.5; E-value: 4.4e-237); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 561.0; E-value: 0.0)