Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000224.1:
Cluster 1Polyketide133064

BGC0000224, fredericamycin biosynthetic gene cluster from Streptomyces griseus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: fredericamycin A
PubChem ID: 5384075
SMILES string: Copy to clipboard
Molecular formula: C30H21NO9
Average molecular mass: 539.496 Da
Molecular activity: Antibacterial, Antifungal, Cytotoxic, Inhibitor, Other

Class-specific details

Biosynthetic class(es):
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Polyketide synthase / ketosynthase-encoding genes:
Genes involved in folding/cyclization:

Gene cluster description

fredericamycin (BGC0000224). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF525490, positions 4971-30565. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Sequence-based prediction
Contact for this cluster:Guohui Pan (The Scripps Research Institute)

Literature references

1. Wendt-Pienkowski E et al. (2005) Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from Streptomyces griseus. J Am Chem Soc 127(47):16442-52. doi: 10.1021/ja054376u.
2. Chen Y et al. (2009) In vivo investigation of the roles of FdmM and FdmM1 in fredericamycin biosynthesis unveiling a new family of oxygenases. J Biol Chem 284(37):24735-43. doi: 10.1074/jbc.M109.014191. Epub
3. Chen Y et al. (2010) Characterization of FdmV as an amide synthetase for fredericamycin A biosynthesis in Streptomyces griseus ATCC 43944. J Biol Chem 285(50):38853-60. doi: 10.1074/jbc.M110.147744. Epub