BGC0000225 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000225 (Streptomyces roseofulvus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	25,306	frenolicin B	PKS	100%

BGC0000225 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 25,306 nt. (total: 25,306 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,307
Label		BGC0000225

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000225	1.00	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000231	0.48	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.32	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0002436	0.31	Other	coformycin	Streptomyces citricolor
BGC0000234	0.30	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000264	0.28	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0000275	0.25	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001197	0.24	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000196	0.23	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000225	1.00	Polyketide	frenolicin B	Streptomyces roseofulvus
BGC0000231	0.77	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.66	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0002436	0.65	Other	coformycin	Streptomyces citricolor
BGC0000234	0.63	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000264	0.61	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000275	0.58	Polyketide	tetracenomycin C	Streptomyces glaucescens
BGC0001197	0.57	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000196	0.57	Polyketide	AQ-256, AQ-270a, AQ-284a	Photorhabdus laumondii subsp. laumondii TTO1

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

frnK

PKS_AT (18..312): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methoxymalonyl-CoA: 54.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 82.2
Methylmalonyl-CoA: 46.7
Methoxymalonyl-CoA: 33.9
Propionyl-CoA: 21.7
Ethylmalonyl-CoA: 17.1
inactive: 14.9
CHC-CoA: 11.2
Benzoyl-CoA: 8.8
2-Methylbutyryl-CoA: 4.6
trans-1,2-CPDA: 3.7
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 25306
Starter unit(s):: butyryl-CoA (Score: 1310.0; E-value: 0)
Malonyl elongations:: 7 (Score: 701.3; E-value: 7.4e-214)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: butyryl-CoA_7: 335 Da

frnI: KSIII (Score: 411.2; E-value: 7.4e-126); KSIII AAC18104.1_Frenolicin_butyryl-CoA (Score: 650.0; E-value: 0.0)
frnJ: ACP (Score: 78.5; E-value: 6.9e-25)
frnK: AT (Score: 391.7; E-value: 6.1e-120); AT AAC18106.1_Frenolicin_butyryl-CoA (Score: 660.0; E-value: 0.0)
frnL: KS (Score: 750.1; E-value: 1.4e-228)
frnM: CLF 7 (Score: 701.3; E-value: 7.4e-214)
frnN: ACP (Score: 103.4; E-value: 1.1e-32)
frnP: KR C9 (Score: 431.1; E-value: 3.2e-132)
frnQ: CYC C7-C12 (Score: 373.9; E-value: 1.2e-114)
frnR: CYC C5-C14 (Score: 471.6; E-value: 2.1e-144)