BGC0000225: frenolicin B biosynthetic gene cluster from Streptomyces roseofulvus
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Location: 1 - 25,306 nt. (total: 25,306 nt).
This entry is originally from NCBI GenBank AF058302.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000225
Short description frenolicin B biosynthetic gene cluster from Streptomyces roseofulvus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AF058302.1
via
Compounds
  • frenolicin B
Species Streptomyces roseofulvus [taxonomy]
References
Chemical products information
frenolicin B Evidence:
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C18H16O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAC18096.1
  • frnA
 1563 - 3875 (+) FrnA
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    • AAC18097.1
    • frnB
    		 3872 - 4843 (+) membrane protein of putative ABC transporter
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      • AAC18098.1
      • frnC
      		 4947 - 5771 (+) membrane component of putative ABC transporter
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        • AAC18099.1
        • frnD
        		 5768 - 7342 (+) ATPase component of putative ABC transporter
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          • AAC18100.1
          • frnE
          		 7460 - 8110 (+) FrnE
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            • AAC18101.1
            • frnF
            		 8271 - 9824 (+) putative antibiotic antiporter
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              • AAC18102.1
              • frnG
              		 10091 - 10939 (+) pathway specific regulator
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                • AAC18103.1
                • frnH
                		 11033 - 11548 (-) actVB homolog
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                  • AAC18104.1
                  • frnI
                  		 11545 - 12555 (-) putative four carbon starter unit synthase
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                    • AAC18105.1
                    • frnJ
                    		 12736 - 12993 (+) acyl carrier protein
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                      • AAC18106.1
                      • frnK
                      		 13081 - 14136 (-) putative acyltransferase for starter unit
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                        • AAC18107.1
                        • frnL
                        		 14336 - 15613 (+) ketoacyl synthase
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                          • AAC18108.1
                          • frnM
                          		 15694 - 16974 (+) chain length factor
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                            • AAC18109.1
                            • frnN
                            		 17047 - 17298 (+) acyl carrier protein
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                              • AAC18110.1
                              • frnO
                              		 17380 - 17862 (-) actVI-ORFA homolog
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                                • AAC18111.1
                                • frnP
                                		 18015 - 18830 (+) ketoreductase
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                                  • AAC18112.1
                                  • frnQ
                                  		 18830 - 19825 (+) aromatase
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                                    • AAC18113.1
                                    • frnR
                                    		 19822 - 20766 (+) cyclase/dehydrase
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                                      • AAC18114.1
                                      • frnS
                                      		 20917 - 21834 (-) FrnS
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                                        • AAC18115.1
                                        • frnT
                                        		 21831 - 23021 (-) putative enoyl reductase
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                                          • AAC18116.1
                                          • frnU
                                          		 23106 - 23432 (-) quinone-forming monooxygenase
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                                            • AAC18117.1
                                            • gapX
                                            		 23613 - 24998 (-) glyceraldehyde-3-phosphate dehydrogenase homolog
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                                              Biosynthesis information
                                              Annotation changelog

                                              Entry version: 4

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-10-07
                                              Update chemical activity to schema version 2.11
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 3

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2022-09-15
                                              Updated bioactivity data
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 2

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2019-10-16
                                              Migrated from v1.4
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              2019-10-16
                                              Updated compound(s) information (NPAtlas curation)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2015-06-12
                                              Submitted
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                              Detailed domain annotation
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