BGC0000226 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000226 (Streptomyces griseoflavus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	33,846	High	gilvocarcin V	PKS

BGC0000226 - Region 1 - T2PKS

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Location: 1 - 33,846 nt. (total: 33,846 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,847
Label		BGC0000226

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

gilF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

gilOI: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

gilOIII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

gilOIV: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

gilR: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

Transferases: acylase glycosyltransferase methyltransferase transferase

gilD: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

gilGT: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

gilMT: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

gilP: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

gilQ: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Lyases: cyclase dehydratase

gilE: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

gilG: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

gilK: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

gilU: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

gilA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

gilB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000226.5	1.00	PKS	gilvocarcin V	Streptomyces griseoflavus
BGC0000231.5	0.80	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000253.4	0.60	PKS	oviedomycin	Streptomyces antibioticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000226.5	1.00	PKS	gilvocarcin V	Streptomyces griseoflavus
BGC0000231.5	0.80	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.74	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.73	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0000253.4	0.60	PKS	oviedomycin	Streptomyces antibioticus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

gilP: mal

PKS_AT (4..294): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 62.9
inactive: 25.9
Propionyl-CoA: 24.6
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 17.4
fatty_acid: 10.1
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gilQ: mal

PKS_AT (23..319): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 79.8
Methylmalonyl-CoA: 44.9
Methoxymalonyl-CoA: 42.9
Propionyl-CoA: 41.8
inactive: 21.1
2-Methylbutyryl-CoA: 17.4
Acetyl-CoA: 16.6
Isobutyryl-CoA: 15.8
Ethylmalonyl-CoA: 15.4
Benzoyl-CoA: 13.3
CHC-CoA: 10.5
trans-1,2-CPDA: 9.5
fatty_acid: 9.1
3-Methylbutyryl-CoA: 6.3

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 33846
Starter unit(s):: propionyl-CoA (Score: 681.0; E-value: 0)
Product class(es):: angucycline

gilA: KS (Score: 676.9; E-value: 2.4e-206)
gilB: CLF (Score: 518.9; E-value: 1.9e-158)
gilC: ACP (Score: 100.3; E-value: 1.1e-31)
gilF: KR C9 (Score: 424.5; E-value: 3.3e-130)
gilG: CYC C4-C17/C2-C19 (Score: 178.1; E-value: 3.9e-55)
gilGT: GT (Score: 337.7; E-value: 2.8e-103)
gilK: CYC C7-C12 (Score: 368.9; E-value: 3.7e-113)
gilMT: MET (Score: 286.9; E-value: 4.8e-88)
gilOI: OXY (Score: 471.0; E-value: 1e-143)
gilOIV: OXY (Score: 299.2; E-value: 1.4e-91)
gilQ: AT (Score: 347.6; E-value: 1.6e-106); AT AAP69595.1_Gilvocarcin_propionyl-CoA (Score: 681.0; E-value: 0.0)