BGC0000226 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000226 (Streptomyces griseoflavus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	33,846	gilvocarcin V	PKS	100%

BGC0000226 - Region 1 - T2PKS

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Location: 1 - 33,846 nt. (total: 33,846 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 33,847
Label		BGC0000226

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000226	1.00	Polyketide	gilvocarcin V	Streptomyces griseoflavus
BGC0000231	0.52	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.43	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.42	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197	0.37	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002435	0.31	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001940	0.29	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0002000	0.27	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000226	1.00	Polyketide	gilvocarcin V	Streptomyces griseoflavus
BGC0000231	0.80	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001723	0.74	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000234	0.73	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197	0.69	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0002435	0.65	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0001940	0.63	Polyketide	pyxidicycline A, pyxidicycline B	Pyxidicoccus fallax
BGC0002000	0.61	Polyketide	setomimycin	Streptomyces aurantiacus JA 4570

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

gilP

PKS_AT (4..294): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 62.9
inactive: 25.9
Propionyl-CoA: 24.6
Methoxymalonyl-CoA: 23.4
Methylmalonyl-CoA: 17.4
fatty_acid: 10.1
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gilQ

PKS_AT (23..319): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 79.8
Methylmalonyl-CoA: 44.9
Methoxymalonyl-CoA: 42.9
Propionyl-CoA: 41.8
inactive: 21.1
2-Methylbutyryl-CoA: 17.4
Acetyl-CoA: 16.6
Isobutyryl-CoA: 15.8
Ethylmalonyl-CoA: 15.4
Benzoyl-CoA: 13.3
CHC-CoA: 10.5
trans-1,2-CPDA: 9.5
fatty_acid: 9.1
3-Methylbutyryl-CoA: 6.3

Type II PKS gene cluster prediction details

Cluster section:: 0 to 33846
Starter unit(s):: propionyl-CoA (Score: 681.0; E-value: 0)
Product class(es):: angucycline

gilA: KS (Score: 676.9; E-value: 2.4e-206)
gilB: CLF (Score: 518.9; E-value: 1.9e-158)
gilC: ACP (Score: 100.3; E-value: 1.1e-31)
gilF: KR C9 (Score: 424.5; E-value: 3.3e-130)
gilG: CYC C4-C17/C2-C19 (Score: 178.1; E-value: 3.9e-55)
gilGT: GT (Score: 337.7; E-value: 2.8e-103)
gilK: CYC C7-C12 (Score: 368.9; E-value: 3.7e-113)
gilMT: MET (Score: 286.9; E-value: 4.8e-88)
gilOI: OXY (Score: 471.0; E-value: 1e-143)
gilOIV: OXY (Score: 299.2; E-value: 1.4e-91)
gilQ: AT (Score: 347.6; E-value: 1.6e-106); AT AAP69595.1_Gilvocarcin_propionyl-CoA (Score: 681.0; E-value: 0.0)