BGC0000227: granaticin biosynthetic gene cluster from Streptomyces violaceoruber
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Location: 1 - 39,250 nt. (total: 39,250 nt).
This entry is originally from NCBI GenBank AJ011500.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000227
Short description granaticin biosynthetic gene cluster from Streptomyces violaceoruber
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
AJ011500.1
via
Compounds
  • granaticin
Species Streptomyces violaceoruber [taxonomy]
References
Chemical products information
granaticin Evidence:
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C22H20O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAA09628.1
  • gra-orf7
 1099 - 2400 (-) putative serine-threonine protein kinase
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    • CAA09629.1
    • gra-orf8
    		 2474 - 3022 (-)
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      • CAA09630.1
      • gra-orf9
      		 3462 - 4313 (+) pathway-specific transcriptional activator
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        • CAA09631.1
        • gra-orf10
        		 4418 - 5026 (-) putative two-component response regulator
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          • CAA09632.1
          • gra-orf11
          		 5125 - 6345 (-) putative two-component sensory kinase
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            • CAA09633.1
            • gra-orf12
            		 6716 - 8971 (-)
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              • CAA09634.1
              • gra-orf13
              		 9059 - 9232 (-)
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                • CAA09635.1
                • gra-orf14
                		 9367 - 10515 (-) putative glycosyl transferase
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                  • CAA09636.1
                  • gra-orf15
                  		 10869 - 12542 (+) putative transmembrane protein
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                    • CAA09637.1
                    • gra-orf16
                    		 12912 - 13973 (+) putative dTDP-1-glucose synthase
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                      • CAA09638.1
                      • gra-orf17
                      		 13970 - 14935 (+) putative dTDP-glucose-4,6-dehydratase
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                        • CAA09639.1
                        • gra-0rf-18
                        		 15086 - 15694 (+) putative cyclase-dehydratase
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                          • CAA09640.1
                          • gra-orf19
                          		 15846 - 16508 (+) putative disulphide bond-forming protein
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                            • CAA09641.1
                            • gra-orf20
                            		 16510 - 17100 (+) putative transcriptional activator
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                              • CAA09642.1
                              • gra-orf21
                              		 17206 - 18408 (-) putative hydroxylase
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                                • CAA09643.1
                                • gra-orf22
                                		 18558 - 19472 (+) putative dTDP4-keto-6-deoxyhexose reductase
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                                  • CAA09644.1
                                  • gra-orf23
                                  		 19615 - 20916 (+) putative CDP-4-keto-6-deoxyglucose-3-dehydratase (E1)
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                                    • CAA09645.1
                                    • gra-orf24
                                    		 21004 - 22245 (-)
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                                      • CAA09646.1
                                      • gra-orf25
                                      		 22242 - 22829 (-) putative dTDP-4-keto-6-deoxyglucose-2,3-dehydratase
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                                        • CAA09647.1
                                        • gra-orf26
                                        		 22844 - 23872 (-)
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                                          • CAA09648.1
                                          • gra-orf27
                                          		 23869 - 25200 (-) putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase
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                                            • CAA09649.1
                                            • gra-orf28
                                            		 25200 - 26000 (-)
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                                              • CAA09650.1
                                              • gra-orf29
                                              		 26093 - 27124 (-) putative FMN-dependent monooxygenase
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                                                • CAA09651.1
                                                • gra-orf6
                                                		 27202 - 27951 (-)
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                                                  • CAA09652.1
                                                  • gra-orf5
                                                  		 27951 - 28769 (-) polyketide ketoreductase
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                                                    • CAA09653.1
                                                    • gra-orf1
                                                    		 29038 - 30303 (+) polyketide synthase keto-acyl synthase
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                                                      • CAA09654.1
                                                      • gra-orf2
                                                      		 30300 - 31547 (+) polyketide synthase chain length factor
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                                                        • CAA09655.1
                                                        • gra-orf3
                                                        		 31629 - 31886 (+) acyl carrier protein
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                                                          • CAA09656.1
                                                          • gra-orf4
                                                          		 32006 - 32980 (+) aromatase
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                                                            • CAA09657.1
                                                            • gra-orf30
                                                            		 33008 - 33856 (-)
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                                                              • CAA09658.1
                                                              • gra-orf31
                                                              		 33991 - 34419 (+)
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                                                                • CAA09659.1
                                                                • gra-orf32
                                                                		 34530 - 35258 (+)
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                                                                  • CAA09660.1
                                                                  • gra-orf33
                                                                  		 35302 - 36267 (+) cyclase
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                                                                    • CAA09661.1
                                                                    • gra-orf34
                                                                    		 36279 - 36818 (-) putative FMN:NADH oxidoreductase
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                                                                      • CAA09662.1
                                                                      • gra-orf35
                                                                      		 37004 - 37471 (+)
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                                                                        • CAA09663.1
                                                                        • gra-orf36
                                                                        		 37617 - 37991 (+)
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                                                                          • CAA09664.1
                                                                          • gra-orf37
                                                                          		 38066 - 38839 (-) putative transcriptional activator
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                                                                            Biosynthesis information
                                                                            Annotation changelog

                                                                            Entry version: 4

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-10-07
                                                                            Update chemical activity to schema version 2.11
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 3

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Remove negative ketide_length
                                                                            • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Removed ketoreductase stereochemistry annotation from modules without ketoreductases
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2022-09-15
                                                                            Removed module fragments from Type II polyketide synthase
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 2

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2019-10-16
                                                                            Migrated from v1.4
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2015-06-12
                                                                            Submitted
                                                                            • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            Detailed domain annotation
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