Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000227.1:
Cluster 1Polyketide139250

BGC0000227, granaticin biosynthetic gene cluster from Streptomyces violaceoruber. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: granaticin
SMILES string: Copy to clipboard
Molecular formula: C22H20O10
Exact molecular mass: 444.1057 Da ([M+H]+)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide subclass:
Ansamycin (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Polyketide synthase / ketosynthase-encoding genes:

Modular polyketide synthases:
gra-orf1 (CAA09653.1)
Module 0
Scaffold-modifying domain: None

gra-orf2 (CAA09654.1)
Module 1
AT specificity: Malonyl-CoA
Evidence for specificity: Sequence-based prediction
Scaffold-modifying domain: None

gra-orf3 (CAA09655.1)
Module 1
Scaffold-modifying domain: None

Gene cluster description

granaticin (BGC0000227). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AJ011500, positions 1-39250. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Sherman DH et al. (1989) Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber Tu22. EMBO J 8(9):2717-25.
2. Bechthold A et al. (1995) Identification of Streptomyces violaceoruber Tu22 genes involved in the biosynthesis of granaticin. Mol Gen Genet 248(5):610-20.
3. Ichinose K et al. (1998) The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tu22: sequence analysis and expression in a heterologous host. Chem Biol 5(11):647-59.