BGC0000227: granaticin biosynthetic gene cluster from Streptomyces violaceoruber
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Location: 1 - 39,250 nt. (total: 39,250 nt).
This entry is originally from NCBI GenBank AJ011500.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000227
Short description granaticin biosynthetic gene cluster from Streptomyces violaceoruber
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Ansamycin)
Loci NCBI GenBank: AJ011500.1
Compounds
  • granaticin
Species Streptomyces violaceoruber [taxonomy]
References
Chemical products information
granaticin
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C22H20O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAA09628.1
  • gra-orf7
 1099 - 2400 (-) putative serine-threonine protein kinase
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  • CAA09629.1
  • gra-orf8
 2474 - 3022 (-)
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  • CAA09630.1
  • gra-orf9
 3462 - 4313 (+) pathway-specific transcriptional activator
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  • CAA09631.1
  • gra-orf10
 4418 - 5026 (-) putative two-component response regulator
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  • CAA09632.1
  • gra-orf11
 5125 - 6345 (-) putative two-component sensory kinase
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  • CAA09633.1
  • gra-orf12
 6716 - 8971 (-)
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  • CAA09634.1
  • gra-orf13
 9059 - 9232 (-)
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  • CAA09635.1
  • gra-orf14
 9367 - 10515 (-) putative glycosyl transferase
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  • CAA09636.1
  • gra-orf15
 10869 - 12542 (+) putative transmembrane protein
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  • CAA09637.1
  • gra-orf16
 12912 - 13973 (+) putative dTDP-1-glucose synthase
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  • CAA09638.1
  • gra-orf17
 13970 - 14935 (+) putative dTDP-glucose-4,6-dehydratase
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  • CAA09639.1
  • gra-0rf-18
 15086 - 15694 (+) putative cyclase-dehydratase
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  • CAA09640.1
  • gra-orf19
 15846 - 16508 (+) putative disulphide bond-forming protein
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  • CAA09641.1
  • gra-orf20
 16510 - 17100 (+) putative transcriptional activator
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  • CAA09642.1
  • gra-orf21
 17206 - 18408 (-) putative hydroxylase
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  • CAA09643.1
  • gra-orf22
 18558 - 19472 (+) putative dTDP4-keto-6-deoxyhexose reductase
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  • CAA09644.1
  • gra-orf23
 19615 - 20916 (+) putative CDP-4-keto-6-deoxyglucose-3-dehydratase (E1)
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  • CAA09645.1
  • gra-orf24
 21004 - 22245 (-)
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  • CAA09646.1
  • gra-orf25
 22242 - 22829 (-) putative dTDP-4-keto-6-deoxyglucose-2,3-dehydratase
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  • CAA09647.1
  • gra-orf26
 22844 - 23872 (-)
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  • CAA09648.1
  • gra-orf27
 23869 - 25200 (-) putative dTDP-4-keto-6-deoxyglucose-3,5-epimerase
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  • CAA09649.1
  • gra-orf28
 25200 - 26000 (-)
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  • CAA09650.1
  • gra-orf29
 26093 - 27124 (-) putative FMN-dependent monooxygenase
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  • CAA09651.1
  • gra-orf6
 27202 - 27951 (-)
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  • CAA09652.1
  • gra-orf5
 27951 - 28769 (-) polyketide ketoreductase
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  • CAA09653.1
  • gra-orf1
 29038 - 30303 (+) polyketide synthase keto-acyl synthase
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  • CAA09654.1
  • gra-orf2
 30300 - 31547 (+) polyketide synthase chain length factor
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  • CAA09655.1
  • gra-orf3
 31629 - 31886 (+) acyl carrier protein
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  • CAA09656.1
  • gra-orf4
 32006 - 32980 (+) aromatase
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  • CAA09657.1
  • gra-orf30
 33008 - 33856 (-)
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  • CAA09658.1
  • gra-orf31
 33991 - 34419 (+)
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  • CAA09659.1
  • gra-orf32
 34530 - 35258 (+)
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  • CAA09660.1
  • gra-orf33
 35302 - 36267 (+) cyclase
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  • CAA09661.1
  • gra-orf34
 36279 - 36818 (-) putative FMN:NADH oxidoreductase
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  • CAA09662.1
  • gra-orf35
 37004 - 37471 (+)
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  • CAA09663.1
  • gra-orf36
 37617 - 37991 (+)
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  • CAA09664.1
  • gra-orf37
 38066 - 38839 (-) putative transcriptional activator
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Polyketide-specific information
Subclass Ansamycin
Starter unit Malonyl-CoA
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
gra-orf2
+
gra-orf3
+
gra-orf1 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: 3UOU7PODQJXIM6BEPUHHRRA5, no GDPR consent given).
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Remove negative ketide_length
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Removed module fragments from Type II polyketide synthase
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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