BGC0000229: grincamycin biosynthetic gene cluster from Streptomyces lusitanus
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 41,909 nt. (total: 41,909 nt).
This entry is originally from NCBI GenBank KC962511.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000229
Short description grincamycin biosynthetic gene cluster from Streptomyces lusitanus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
KC962511.1
via Knock-out studies
Compounds
  • grincamycin
Species Streptomyces lusitanus [taxonomy]
References
Chemical products information
grincamycin Evidence:
Copy SMILES
C49H62O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGO50601.1
 1 - 600 (+) hypothetical protein
    copy AA seq
    copy Nt seq
    • AGO50602.1
    		 763 - 2388 (+) malate synthase
      copy AA seq
      copy Nt seq
      • AGO50603.1
      		 2682 - 3605 (-) hypothetical protein
        copy AA seq
        copy Nt seq
        • AGO50604.1
        		 3722 - 4840 (-) putative oxidoreductase
        • Tailoring
        copy AA seq
        copy Nt seq
        • AGO50605.1
        		 5064 - 6581 (-) transporter
        • Transport
        copy AA seq
        copy Nt seq
        • AGO50606.1
        		 6612 - 7211 (-) NADPH-dependent fmn reductase
        • Tailoring
        copy AA seq
        copy Nt seq
        • AGO50607.1
        		 7242 - 8081 (+) tetr family transcriptional regulator
        • Regulation
        copy AA seq
        copy Nt seq
        • AGO50608.1
        		 8228 - 9070 (+) hypothetical protein
          copy AA seq
          copy Nt seq
          • AGO50609.1
          		 9396 - 10883 (+) oxidoreductase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50610.1
          		 11220 - 12500 (+) ketoacyl synthase
          • Precursor biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50611.1
          		 12497 - 13717 (+) chain length determinant
          • Precursor biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50612.1
          		 13794 - 14063 (+) acyl carrier protein
          • Precursor biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50613.1
          		 14192 - 14977 (+) ketoreductase
          • Precursor biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50614.1
          		 14998 - 15933 (+) cyclase
          • Precursor biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50615.1
          		 15935 - 17923 (+) oxygenase-reductase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50616.1
          		 17936 - 19153 (+) transporter
          • Transport
          copy AA seq
          copy Nt seq
          • AGO50617.1
          		 19194 - 20486 (+) glycosyltransferase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50618.1
          		 20516 - 21730 (+) glycosyltransferases
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50619.1
          		 21799 - 22293 (+) NDP-hexose 3, 5-epimerase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50620.1
          		 22296 - 23426 (+) glycosyltransferase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50621.1
          		 23455 - 24522 (+) dNDP-glucose synthetase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50622.1
          		 24519 - 25502 (+) dNDP-glucose 4,6-dehydratase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50623.1
          		 25537 - 26547 (+) NDP-hexose 4-ketoreductase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50624.1
          		 26550 - 27854 (+) NDP-hexose 3,4-dehydratase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50625.1
          		 27907 - 28671 (+) NDP-hexose 4-ketoreductase
          • Tailoring
          • Knock-out
          copy AA seq
          copy Nt seq
          • AGO50626.1
          		 28700 - 29653 (+) hypothetical protein
            copy AA seq
            copy Nt seq
            • AGO50627.1
            		 29709 - 31112 (+) NDP-hexose 2,3-dehydratase
            • Tailoring
            • Knock-out
            copy AA seq
            copy Nt seq
            • AGO50628.1
            		 31109 - 32068 (+) NDP-hexose 3-ketoreductase
            • Tailoring
            • Knock-out
            copy AA seq
            copy Nt seq
            • AGO50629.1
            		 32089 - 33624 (+) carboxyl transferase
            • Tailoring
            copy AA seq
            copy Nt seq
            • AGO50630.1
            		 34149 - 35738 (+) FAD/FMN-containin-g dehydrogenase
            • Tailoring
            • Knock-out
            copy AA seq
            copy Nt seq
            • AGO50631.1
            		 36425 - 37135 (-) positive regulation regulator
            • Regulation
            copy AA seq
            copy Nt seq
            • AGO50632.1
            		 37802 - 39598 (+) putative oxidoreductase
            • Tailoring
            copy AA seq
            copy Nt seq
            • AGO50633.1
            		 39588 - 40613 (+) putative oxidoreductase
            • Tailoring
            copy AA seq
            copy Nt seq
            • AGO50634.1
            		 40953 - >41909 (-) putative integral membrane export protein
              copy AA seq
              copy Nt seq
              Biosynthesis information
              Annotation changelog

              Entry version: 4

              Date
              Changes
              Submitters
              Reviewers
              2022-10-07
              Update chemical activity to schema version 2.11
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 3

              Date
              Changes
              Submitters
              Reviewers
              2022-09-15
              Corrected polyketide synthase gene entries
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2022-09-15
              Updated bioactivity data
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 2

              Date
              Changes
              Submitters
              Reviewers
              2019-10-16
              Migrated from v1.4
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              2019-10-16
              Updated compound(s) information (NPAtlas curation)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

              Entry version: 1

              Date
              Changes
              Submitters
              Reviewers
              2015-06-12
              Submitted
              • (ID: AADADFAEMFE2AOMR24EUYNFH)
              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
              Detailed domain annotation
              Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
              A domain glossary is available here, and an explanation of the visualisation is available here.
              Selected features only
              Show module domains
              Similar known gene clusters from MIBiG 4.0
              Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
              Click on reference genes to show details of similarities to genes within the current region.
              Click on an accession to open that entry in the MiBIG database.