BGC0000229: grincamycin biosynthetic gene cluster from Streptomyces lusitanus
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Location: 1 - 41,909 nt. (total: 41,909 nt).
This entry is originally from NCBI GenBank KC962511.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000229
Short description grincamycin biosynthetic gene cluster from Streptomyces lusitanus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Angucycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KC962511.1
Compounds
  • grincamycin
Species Streptomyces lusitanus [taxonomy]
References
Chemical products information
grincamycin [synonyms: vineomycin a1, vineomycin b1]
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C49H62O18
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGO50601.1
 1 - 600 (+) hypothetical protein
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  • AGO50602.1
 763 - 2388 (+) malate synthase
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  • AGO50603.1
 2682 - 3605 (-) hypothetical protein
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  • AGO50604.1
 3722 - 4840 (-) putative oxidoreductase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AGO50605.1
 5064 - 6581 (-) transporter
  • Transport
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  • AGO50606.1
 6612 - 7211 (-) NADPH-dependent fmn reductase
  • Tailoring (Reduction)
Sequence-based prediction
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  • AGO50607.1
 7242 - 8081 (+) tetr family transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AGO50608.1
 8228 - 9070 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • AGO50609.1
 9396 - 10883 (+) oxidoreductase
  • Tailoring (Oxidation)
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  • AGO50610.1
 11220 - 12500 (+) ketoacyl synthase
  • Precursor biosynthesis
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  • AGO50611.1
 12497 - 13717 (+) chain length determinant
  • Precursor biosynthesis
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  • AGO50612.1
 13794 - 14063 (+) acyl carrier protein
  • Precursor biosynthesis
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  • AGO50613.1
 14192 - 14977 (+) ketoreductase
  • Precursor biosynthesis
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  • AGO50614.1
 14998 - 15933 (+) cyclase
  • Precursor biosynthesis
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  • AGO50615.1
 15935 - 17923 (+) oxygenase-reductase
  • Tailoring (Oxidation)
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  • AGO50616.1
 17936 - 19153 (+) transporter
  • Transport
Sequence-based prediction
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  • AGO50617.1
 19194 - 20486 (+) glycosyltransferase
  • Tailoring (Glycosylation)
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  • AGO50618.1
 20516 - 21730 (+) glycosyltransferases
  • Tailoring (Glycosylation)
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  • AGO50619.1
 21799 - 22293 (+) NDP-hexose 3, 5-epimerase
  • Tailoring (Epimerization)
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  • AGO50620.1
 22296 - 23426 (+) glycosyltransferase
  • Tailoring (Glycosylation)
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  • AGO50621.1
 23455 - 24522 (+) dNDP-glucose synthetase
  • Tailoring (Unknown)
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  • AGO50622.1
 24519 - 25502 (+) dNDP-glucose 4,6-dehydratase
  • Tailoring (Dehydration)
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  • AGO50623.1
 25537 - 26547 (+) NDP-hexose 4-ketoreductase
  • Tailoring (Reduction)
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  • AGO50624.1
 26550 - 27854 (+) NDP-hexose 3,4-dehydratase
  • Tailoring (Dehydration)
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  • AGO50625.1
 27907 - 28671 (+) NDP-hexose 4-ketoreductase
  • Tailoring (Reduction)
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  • AGO50626.1
 28700 - 29653 (+) hypothetical protein
  • Unknown
Sequence-based prediction
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  • AGO50627.1
 29709 - 31112 (+) NDP-hexose 2,3-dehydratase
  • Tailoring (Dehydration)
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  • AGO50628.1
 31109 - 32068 (+) NDP-hexose 3-ketoreductase
  • Tailoring (Reduction)
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  • AGO50629.1
 32089 - 33624 (+) carboxyl transferase
  • Tailoring (Carboxylation)
Sequence-based prediction
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  • AGO50630.1
 34149 - 35738 (+) FAD/FMN-containin-g dehydrogenase
  • Tailoring (Dehydration)
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  • AGO50631.1
 36425 - 37135 (-) positive regulation regulator
  • Regulation
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  • AGO50632.1
 37802 - 39598 (+) putative oxidoreductase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AGO50633.1
 39588 - 40613 (+) putative oxidoreductase
  • Tailoring (Reduction)
Sequence-based prediction
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  • AGO50634.1
 40953 - >41909 (-) putative integral membrane export protein
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Polyketide-specific information
Subclass Angucycline
Starter unit Malonyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AGO50610.1
+
AGO50611.1
+
AGO50612.1
+
AGO50614.1
+
AGO50613.1 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AADADFAEMFE2AOMR24EUYNFH, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected polyketide synthase gene entries
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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