Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000229.1:
Cluster 1Polyketide / Saccharide141909

BGC0000229, grincamycin biosynthetic gene cluster from Streptomyces lusitanus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: grincamycin
SMILES string: Copy to clipboard
Molecular formula: C49H62O18
Exact molecular mass: 938.3936 Da (None)
Molecular activity: Cytotoxic
Molecular target: endoplasmic reticulum

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AGO50610.1,AGO50611.1,AGO50612.1
Genes involved in folding/cyclization:
AGO50613.1,AGO50614.1

Gene cluster description

grincamycin (BGC0000229). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KC962511, positions 3722-40613. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Jianhua Ju ( Guangdong Key Laboratory of Marine Materia Medica Deputy director, Key Laboratory of Marine Bio-resources Sustainable Utilization,CAS South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS))

Literature references

1. Zhang Y et al. (2013) Identification of the grincamycin gene cluster unveils divergent roles for GcnQ in different hosts, tailoring the L-rhodinose moiety. Org Lett 15(13):3254-7. doi: 10.1021/ol401253p. Epub 2013 Jun 19.